Compile Data Set for Download or QSAR
Report error Found 11808 of ki data for polymerid = 1192,50007428,50007429
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50114862(CHEMBL3608874)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50114861(CHEMBL3608873)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093585(CHEMBL3585779)
Affinity DataKi:  0.0460nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093587(CHEMBL3585777)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50114853(CHEMBL3608890)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50114857(CHEMBL3608894)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50252993(CHEMBL4073678)
Affinity DataKi:  0.120nMAssay Description:Non-competitive inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by Linew...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50252992(CHEMBL4100496)
Affinity DataKi:  0.120nMAssay Description:Competitive inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by Lineweave...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093588(CHEMBL3585776)
Affinity DataKi:  0.127nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093589(CHEMBL3585775)
Affinity DataKi:  0.127nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093586(CHEMBL3585778)
Affinity DataKi:  0.140nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093584(CHEMBL3585780)
Affinity DataKi:  0.275nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50252996(CHEMBL4097972)
Affinity DataKi:  0.370nMAssay Description:Competitive inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by Lineweave...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222046((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-methoxyphenyl)acryl...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222048((3aR,4S,7R,7aS)-2-(4-((E)-3-(p-tolyl)acryloyl)phen...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222047((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-methoxyphenyl)acryl...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222050((3aR,4S,7R,7aS)-2-(4-((E)-3-(o-tolyl)acryloyl)phen...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222049((3aR,4S,7R,7aS)-2-(4-((E)-3-(m-tolyl)acryloyl)phen...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222052((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-chlorophenyl)acrylo...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222051((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-chlorophenyl)acrylo...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222054((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-bromophenyl)acryloy...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222053((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-chlorophenyl)acrylo...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222056((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-bromophenyl)acryloy...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222055((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-bromophenyl)acryloy...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222058((3aR,4S,7R,7aS)-2-(4-((E)-3-(thiophen-2-yl)acryloy...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222057((3aR,4S,7R,7aS)-2-(4-((E)-3-(furan-2-yl)acryloyl)p...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222059((3aR,4S,7R,7aS)-2-(4-((E)-3-(pyridin-4-yl)acryloyl...)
Affinity DataKi:  0.405nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222056((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-bromophenyl)acryloy...)
Affinity DataKi:  0.405nM ΔG°:  -53.6kJ/mole IC50: 0.573nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222054((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-bromophenyl)acryloy...)
Affinity DataKi:  0.442nM ΔG°:  -53.4kJ/mole IC50: 0.466nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222047((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-methoxyphenyl)acryl...)
Affinity DataKi:  0.469nM ΔG°:  -53.2kJ/mole IC50: 0.606nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222051((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-chlorophenyl)acrylo...)
Affinity DataKi:  0.475nM ΔG°:  -53.2kJ/mole IC50: 0.506nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093583(CHEMBL3585781)
Affinity DataKi:  0.479nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222055((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-bromophenyl)acryloy...)
Affinity DataKi:  0.501nM ΔG°:  -53.1kJ/mole IC50: 0.597nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222046((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-methoxyphenyl)acryl...)
Affinity DataKi:  0.513nM ΔG°:  -53.0kJ/mole IC50: 0.639nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222052((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-chlorophenyl)acrylo...)
Affinity DataKi:  0.518nM ΔG°:  -53.0kJ/mole IC50: 0.619nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM13075(2000-01951 | 2,4-dichloro-5-sulfamoylbenzoic acid ...)
Affinity DataKi:  0.520nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222049((3aR,4S,7R,7aS)-2-(4-((E)-3-(m-tolyl)acryloyl)phen...)
Affinity DataKi:  0.523nM ΔG°:  -53.0kJ/mole IC50: 0.579nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222050((3aR,4S,7R,7aS)-2-(4-((E)-3-(o-tolyl)acryloyl)phen...)
Affinity DataKi:  0.529nM ΔG°:  -52.9kJ/mole IC50: 0.537nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50233597(CHEMBL4091363)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human CA1 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222059((3aR,4S,7R,7aS)-2-(4-((E)-3-(pyridin-4-yl)acryloyl...)
Affinity DataKi:  0.549nM ΔG°:  -52.9kJ/mole IC50: 0.611nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50093581(CHEMBL3585783)
Affinity DataKi:  0.565nMAssay Description:Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222057((3aR,4S,7R,7aS)-2-(4-((E)-3-(furan-2-yl)acryloyl)p...)
Affinity DataKi:  0.595nM ΔG°:  -52.7kJ/mole IC50: 0.655nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222048((3aR,4S,7R,7aS)-2-(4-((E)-3-(p-tolyl)acryloyl)phen...)
Affinity DataKi:  0.605nM ΔG°:  -52.6kJ/mole IC50: 0.597nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50155545(5-{4-[3-(4-Methyl-piperazin-1-yl)-thioureido]-benz...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50155542(5-{4-[3-(2-Dimethylamino-ethyl)-thioureido]-benzen...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50155547(5-(4-{3-[1,2-Dihydroxy-2-(4-nitro-phenyl)-ethyl]-t...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM222053((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-chlorophenyl)acrylo...)
Affinity DataKi:  0.603nM ΔG°:  -52.6kJ/mole IC50: 0.650nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50252994(CHEMBL4082551)
Affinity DataKi:  0.630nMAssay Description:Non-competitive inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by Linew...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50517085(CHEMBL4545711)
Affinity DataKi:  0.630nMAssay Description:Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
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