Compile Data Set for Download or QSAR
Report error Found 25 of ki data for polymerid = 124
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 12197BDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Caspase-8 (unknown origin) using Ac-IETD-AFC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281182BDBM50281182(3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...)
Affinity DataKi:  42nMAssay Description:Binding affinity to Caspase-8 (unknown origin) using Ac-IETD-AFC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 225BDBM225(Thiophene Scaffold 66a | (S)-5-5-(1-Carboxymethyl-...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281184BDBM50281184((S)-3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  100nMAssay Description:Binding affinity to Caspase-8 (unknown origin) using Ac-IETD-AFC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 220BDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  150nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 226BDBM226(Thiophene Scaffold 66b | (S)-5-({5-[1-Carboxymethy...)
Affinity DataKi:  330nM ΔG°:  -37.0kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116260BDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  350nMAssay Description:Compound was tested for its inhibition against Caspase-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200932BDBM50200932((3S)-3-[(2S)-6-(6-{5-[(3aS,6aR)-2-oxo-hexahydro-1H...)
Affinity DataKi:  540nMAssay Description:Inhibition of human caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281183BDBM50281183((S)-3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  610nMAssay Description:Binding affinity to Caspase-8 (unknown origin) using Ac-IETD-AFC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 227BDBM227(Heterocyclic deriv. 69b | (S)-5-({5-[1-Carboxymeth...)
Affinity DataKi:  710nM ΔG°:  -35.1kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222BDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  810nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 221BDBM221(Pyridine Scaffold 4 | 5-{[(5-{[(2S)-1-carboxy-3-ox...)
Affinity DataKi:  880nM ΔG°:  -34.6kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10215BDBM10215(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-[3-(trifluo...)
Affinity DataKi:  2.70E+3nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 219BDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  4.00E+3nM ΔG°:  -30.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10323BDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataKi: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 224BDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  1.90E+4nM ΔG°:  -26.9kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10305BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 223BDBM223(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  2.80E+4nM ΔG°:  -26.0kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10216BDBM10216(ethyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thi...)
Affinity DataKi:  3.00E+4nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10298BDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  3.10E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10318BDBM10318(5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}...)
Affinity DataKi:  4.90E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10297BDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10309BDBM10309(5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10316BDBM10316(5-{[(2R)-2-[(phenylamino)methyl]pyrrolidine-1-]sul...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
L J University Ahmedabad

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10315BDBM10315(5-{[(2S)-2-[(phenylamino)methyl]pyrrolidine-1-]sul...)
Affinity DataKi:  8.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed