Compile Data Set for Download or QSAR
maximum 50k data
Found 686 of ki data for polymerid = 369,49000511,50002382
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.0300nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.0400nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50462974(CHEMBL4240100)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at full length recombinant human ERalpha expressed in baculovirus expression system assessed as inhibition of estradiol-induced E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212159(2-(4-isopropylphenyl)-3-(4-(2-(piperidin-1-yl)etho...)
Affinity DataKi:  0.0910nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50076331(1-(hydroxymethyl)-12-(4-hydroxyphenyl)-1,12-dicarb...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibition of [6,7-3H]-17beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238727(CHEMBL4065838)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50133070(CHEMBL335465 | [1,1';2',1'']Terphenyl-4'-carbaldeh...)
Affinity DataKi:  0.150nMAssay Description:Relative binding affinity for human estrogen receptor alpha compared to [3H]-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [2,4,6,7-3H]estradiol from human ERalpha expressed in HeLa cells after 18 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212148(6-(3-fluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238724(CHEMBL4060067)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212157(6-(3,4-difluorophenyl)-5-(4-(2-(piperidin-1-yl)eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19964(6-(4-hydroxyphenyl)-5-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/mole EC50:  1.14nMpH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212149(6-(3-hydroxyphenyl)-5-(4-(2-(piperidin-1-yl)ethoxy...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osboum et al. (1993, Biochemistry, 32, 6229-6236). Recombin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.220nMAssay Description:Ability to displace [3H]-17-beta-estradiol from Estrogen receptor alpha by scintillation proximity assay.More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.230nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osboum et al. (1993, Biochemistry, 32, 6229-6236). Recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19967(6-(4-fluorophenyl)-5-{4-[2-(piperidin-1-yl)ethoxy]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212160(3-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenox...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19967(6-(4-fluorophenyl)-5-{4-[2-(piperidin-1-yl)ethoxy]...)
Affinity DataKi:  0.25nM ΔG°:  -54.3kJ/mole EC50:  3.18nMpH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50055569(CHEMBL46937 | [2-(4-Butyl-phenyl)-6-hydroxy-benzo[...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50055569(CHEMBL46937 | [2-(4-Butyl-phenyl)-6-hydroxy-benzo[...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to ERalpha ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.25nMAssay Description:In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238716(CHEMBL4079530)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50102902(5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-5,6-dihydro...)
Affinity DataKi:  0.280nMAssay Description:Binding affinity for Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.300nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged ERalpha expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50181362((R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]17beta-estradiol from ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Mus musculus)
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to ERalpha receptor in mouse COS7 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443430(US10654866, Example 1B | US11117902, Example 1A | ...)
Affinity DataKi:  0.310nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443430(US10654866, Example 1B | US11117902, Example 1A | ...)
Affinity DataKi:  0.310nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  0.310nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50212147(6-(4-hydroxyphenyl)-5-(4-(2-(piperidin-1-yl)ethoxy...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238726(CHEMBL4083780)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  0.340nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  0.340nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  0.340nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19977((2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238743(CHEMBL4070669)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238720(CHEMBL4102857)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50104326(4-{3-(4-hydroxy-phenyl)-4-ethyl-5-[4-(2-piperidin-...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238739(CHEMBL4079644)
Affinity DataKi:  0.370nMAssay Description:Inhibition constant was evaluated against Histamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.370nM ΔG°:  -53.3kJ/mole EC50:  4.32nMpH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238742(CHEMBL4062045)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50090462(CHEMBL3581693)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50238733(CHEMBL4099302)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to ERalpha ligand binding domainMore data for this Ligand-Target Pair
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