Compile Data Set for Download or QSAR
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TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM404301(US10017501, Compound 1020-289)
Affinity DataKi:  2nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249309(US9458145, 1020-114 | US10017501, Compound 1020-11...)
Affinity DataKi:  3.80nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249305(US9458145, 1020-103 | US10017501, Compound 1020-10...)
Affinity DataKi:  4nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249312(US9458145, 1020-257 | US10017501, Compound 1020-25...)
Affinity DataKi:  4.70nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249314(US9458145, 1020-298 | US10017501, Compound 1020-29...)
Affinity DataKi:  5.40nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249311(US9458145, 1020-239 | US10017501, Compound 1020-23...)
Affinity DataKi:  5.90nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249306(US9458145, 1020-104 | US10017501, Compound 1020-10...)
Affinity DataKi:  7.20nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179480(US9675697, Cpd. No. 68)
Affinity DataKi:  7.30nM ΔG°:  -46.4kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179485(US9675697, Cpd. No. 183)
Affinity DataKi:  7.90nM ΔG°:  -46.2kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179638(US9675697, Cpd. No. 319)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179639(US9675697, Cpd. No. 322)
Affinity DataKi:  10nM ΔG°:  -45.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50539805(CHEMBL4644032 | US11840533, Compound 72)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249307(US9458145, 1020-112 | US10017501, Compound 1020-11...)
Affinity DataKi:  10.4nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249308(US9458145, 1020-113 | US10017501, Compound 1020-11...)
Affinity DataKi:  10.7nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249310(US9458145, 1020-224 | US10017501, Compound 1020-22...)
Affinity DataKi:  10.8nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179633(US9675697, Cpd. No. 316)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179490(US9675697, Cpd. No. 196)
Affinity DataKi:  12nM ΔG°:  -45.2kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179492(US9675697, Cpd. No. 207)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179574(US9675697, Cpd. No. 212)
Affinity DataKi:  17nM ΔG°:  -44.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179491(US9675697, Cpd. No. 197)
Affinity DataKi:  17nM ΔG°:  -44.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179493(US9675697, Cpd. No. 211)
Affinity DataKi:  17nM ΔG°:  -44.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179627(US9675697, Cpd. No. 213)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  27nM ΔG°:  -43.2kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKi:  35nM ΔG°:  -42.6kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179637(US9675697, Cpd. No. 317)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092341(US9675697, Cpd. No. 22 | CHEMBL3581660)
Affinity DataKi:  44nM ΔG°:  -42.0kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092324(US9675697, Cpd. No. 1 | CHEMBL3581655)
Affinity DataKi:  48nM ΔG°:  -41.8kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092323(US9675697, Cpd. No. 21 | CHEMBL3581656)
Affinity DataKi:  99nM ΔG°:  -40.0kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM640358(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM640356(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM640357(N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...)
Affinity DataKi: <100nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179640(US9675697, Cpd. No. 352)
Affinity DataKi:  103nM ΔG°:  -39.9kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092316(US9675697, Cpd. No. 24 | CHEMBL3581658)
Affinity DataKi:  116nM ΔG°:  -39.6kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092318(US9675697, Cpd. No. 2 | CHEMBL3581657)
Affinity DataKi:  247nM ΔG°:  -37.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092330(US9675697, RX-3 | CHEMBL3581649)
Affinity DataKi:  305nM ΔG°:  -37.2kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM186322(US9675697, RX-39)
Affinity DataKi:  1.24E+3nM ΔG°:  -33.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092339(US9675697, RX-7 | CHEMBL3581648)
Affinity DataKi:  1.64E+3nM ΔG°:  -33.0kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM179475(US9675697, Cpd. No. 33)
Affinity DataKi:  1.73E+3nM ΔG°:  -32.9kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM186321(US9675697, RX-38)
Affinity DataKi:  2.81E+3nM ΔG°:  -31.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092325(US9675697, RX-27 | CHEMBL3581654)
Affinity DataKi:  4.84E+3nM ΔG°:  -30.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent