Compile Data Set for Download or QSAR
Report error Found 39 of ki data for polymerid = 4946,8646,50006516,50006634
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019329(CHEMBL1089318)
Affinity DataKi:  1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315227(Isopropyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]th...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315228(Butyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thioph...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019329(CHEMBL1089318)
Affinity DataKi:  1.5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Mouse)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019329(CHEMBL1089318)
Affinity DataKi:  1.5nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315220((2-oxo-1,3-dioxol-4-yl)methyl 3-chloro-5,6-dihydro...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315230(Methyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315221((2-amino-3-methylbutanoyloxy)methyl 3-chloro-5,6-d...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315229(Propyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315226(Benzyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315223(Butyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitroben...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315222(1-(Butyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  16.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315224(1-(Isobutyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-ni...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315225(Isobutyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058814(N,N'-1,3-Propanediylbis(3,4-dihydroxybenzamide) | ...)
Affinity DataKi:  300nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Competitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058813(3,4,5-Trihydroxy-N-propyl-benzamide | CHEMBL64275)
Affinity DataKi:  500nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Competitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019331(CHEMBL3289430)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058812(N,N'-1,3-Propanediylbis(3,4,5-trihydroxybenzamide)...)
Affinity DataKi:  6.60E+3nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019333(CHEMBL3289432)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50004044(CHEMBL89320 | 3-Hydroxy-4-methoxy-5-nitro-benzalde...)
Affinity DataKi:  1.35E+4nMAssay Description:Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with variable AdoMet and saturating catechol as substrate (mixed inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50004044(CHEMBL89320 | 3-Hydroxy-4-methoxy-5-nitro-benzalde...)
Affinity DataKi:  1.72E+4nMAssay Description:Compound was evaluated for reversible inhibition of Catechol O-methyltransferase with saturating AdoMet and variable catechol as substrate (Non-compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019332(CHEMBL3289431)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058815(N,N'-1,5-Pentanediylbis(3,4,5-trihydroxybenzamide)...)
Affinity DataKi:  2.67E+4nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058811(N,N'-1,6-Hexanediylbis(3,4,5-trihydroxybenzamide)H...)
Affinity DataKi:  3.50E+4nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Mouse)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019331(CHEMBL3289430)
Affinity DataKi:  6.30E+4nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Pig)
University of Otago

Curated by ChEMBL
LigandPNGBDBM50058816(N,N'-1,2-Ethanediylbis(3,4,5-trihydroxybenzamide)H...)
Affinity DataKi:  1.36E+5nMAssay Description:In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019331(CHEMBL3289430)
Affinity DataKi:  1.58E+5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019330(CHEMBL3289429)
Affinity DataKi:  2.51E+5nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50012672(CHEMBL303916 | 3-(2-Amino-ethyl)-1H-indole-5,6-dio...)
Affinity DataKi:  3.28E+5nMAssay Description:Kinetic constants for the inactivation of Catechol O-methyltransferase by the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50367029(CHEMBL553016)
Affinity DataKi:  5.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50367030(CHEMBL539878)
Affinity DataKi:  8.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50367031(CHEMBL557014)
Affinity DataKi:  8.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50028548(1H-indole-5,6-diol | 5,6-dihydroxyindole | Dopamin...)
Affinity DataKi:  3.46E+6nMAssay Description:Kinetic constants for the inactivation of Catechol O-methyltransferase by the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50028547(4-Methyl-1H-indole-5,6-diol | CHEMBL90571)
Affinity DataKi:  1.52E+7nMAssay Description:Kinetic constants for the inactivation of Catechol O-methyltransferase by the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50028546(4,7-Dimethyl-1H-indole-5,6-diol | CHEMBL90203)
Affinity DataKi:  7.26E+6nMAssay Description:Kinetic constants for the inactivation of Catechol O-methyltransferase by the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50028545(7-Methyl-1H-indole-5,6-diol | CHEMBL431031)
Affinity DataKi:  1.14E+6nMAssay Description:Kinetic constants for the inactivation of Catechol O-methyltransferase by the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50367028(CHEMBL553200)
Affinity DataKi:  5.80E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM22111((2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfa...)
Affinity DataKi: >5.40E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50366942(CHEMBL540135)
Affinity DataKi:  6.00E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed