Compile Data Set for Download or QSAR
maximum 50k data
Found 485 of ki data for polymerid = 6139,49000552
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133600(US8846719, 311)
Affinity DataKi:  0.100nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133597(US8846719, 308)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10521(US8846719, 303)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133596(US8846719, 306)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10673(US8846719, 289)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10484(US11091471, Example RO-301 | US8846719, 301)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10517(US8846719, 302)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10467(US8846719, 294)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10711(US8846719, 292)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10468(US8846719, 295)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133578(US8846719, 270)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10672(US8846719, 288)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133599(US8846719, 310)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  0.450nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10667(US8846719, 284)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10483(US8846719, 297)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133568(US8846719, 260)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133594(US8846719, 299)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133565(US8846719, 257)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133598(US8846719, 309)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM11505(US8846719, 307)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133593(US8846719, 305)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10677(US8846719, 290)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133581(US8846719, 273)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133542(US8846719, 234)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133595(US8846719, 298)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  0.631nMAssay Description:Binding affinity to GABBA alpha5 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50244227(CHEMBL458147 | tert-butyl 7-chloro-4-methyl-5-oxo-...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50144858(3-(5-Methyl-isoxazol-3-yl)-6-(1-methyl-1H-[1,2,3]t...)
Affinity DataKi:  0.660nMAssay Description:Binding affinity to GABA-A alpha5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133422(US8846719, 107)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133518(US8846719, 208)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133507(US8846719, 196)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133433(US8846719, 119)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133567(US8846719, 259)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133563(US8846719, 255)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133435(US8846719, 121)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133561(US8846719, 253)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133564(US8846719, 256)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133424(US8846719, 109)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  0.810nMMore data for this Ligand-Target Pair
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  0.830nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50244195(CHEMBL453251 | ethyl 7-chloro-4-methyl-5-oxo-4,5-d...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM403740(6-Chloro-7-((3-(cyclopropylmethyl)-7-methyl-3H-imi...)
Affinity DataKi:  0.900nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133559(US11091471, Example RO-251 | US8846719, 251)
Affinity DataKi:  0.900nM ΔG°:  -48.0kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133560(US8846719, 252)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133501(US8846719, 190)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  1.03nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133423(US8846719, 108)
Affinity DataKi:  1.10nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
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