Compile Data Set for Download or QSAR
Report error Found 145 of ki data for polymerid = 7498
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103964(CHEMBL3593932)
Affinity DataKi:  2.10nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50614056(CHEMBL5274551)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to Alpha-synuclein (unknown origin) fibrils assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103961(CHEMBL3593930)
Affinity DataKi:  3.5nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633984(CHEMBL5404722)
Affinity DataKi:  3.5nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103936(CHEMBL3593928)
Affinity DataKi:  3.80nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104103(CHEMBL3593911)
Affinity DataKi:  4.20nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481149(US10906900, Reference 22a)
Affinity DataKi:  4.70nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633992(CHEMBL5413730)
Affinity DataKi:  8.5nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633986(CHEMBL5436166)
Affinity DataKi:  9.20nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633998(CHEMBL5435534)
Affinity DataKi:  9.40nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680874(US12012394, Compound TZ64-105)
Affinity DataKi:  10nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680875(US12012394, Compound TZ64-19)
Affinity DataKi:  10.4nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680876(US12012394, Compound TZ66-16)
Affinity DataKi:  11nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103979(CHEMBL3593904)
Affinity DataKi:  12nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680873(US12012394, Compound TZ64-102)
Affinity DataKi:  12nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103934(CHEMBL3593926)
Affinity DataKi:  13nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481153(US10906900, Reference 22f)
Affinity DataKi:  14.8nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104109(CHEMBL3593922)
Affinity DataKi:  15nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633991(CHEMBL5420714)
Affinity DataKi:  15nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680871(US12012394, Compound TZ64-55)
Affinity DataKi:  15nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633993(CHEMBL5405459)
Affinity DataKi:  16nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633985(CHEMBL5399057)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50634000(CHEMBL5414142)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50634002(CHEMBL5402429)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50634003(CHEMBL5434091)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50634004(CHEMBL5422515)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50634005(CHEMBL5431199)
Affinity DataKi:  17nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680864(US12012394, Compound 28)
Affinity DataKi:  17nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680877(US12012394, Compound TZ66-25)
Affinity DataKi:  17nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680872(US12012394, Compound TZ64-82)
Affinity DataKi:  18nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM680878(US12012394, Compound TZ64-91)
Affinity DataKi:  18nMAssay Description:α-Synuclein recombinant protein was produced in E. coli. BL21(DE3)RIL E. coli were transformed with a pRK172 bacterial expression plasmid contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481154(US10906900, Reference 22g)
Affinity DataKi:  19nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481155(US10906900, Reference 22h)
Affinity DataKi:  20.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103932(CHEMBL3593924)
Affinity DataKi:  25nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50185987(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Affinity DataKi:  25.1nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481151(US10906900, Reference 22c)
Affinity DataKi:  26nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481150(US10906900, Reference 22b)
Affinity DataKi:  28.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633994(CHEMBL5415091)
Affinity DataKi:  29nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104145(CHEMBL3593915)
Affinity DataKi:  30nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633997(CHEMBL5423638)
Affinity DataKi:  31nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50389294(CHEMBL2063787)
Affinity DataKi:  32.1nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104059(CHEMBL3593909)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103927(CHEMBL3593903)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633989(CHEMBL5400950)
Affinity DataKi:  42nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104144(CHEMBL3593916)
Affinity DataKi:  44nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104116(CHEMBL3593918)
Affinity DataKi:  45nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50104106(CHEMBL3593913)
Affinity DataKi:  45nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50389304(CHEMBL2063797)
Affinity DataKi:  49nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM481152(US10906900, Reference 22e)
Affinity DataKi:  49.9nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50633996(CHEMBL5435422)
Affinity DataKi:  51nMAssay Description:Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
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