Compile Data Set for Download or QSAR
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Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527134BDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in HEK293 cells using AMP as substrate preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527134BDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of CD73 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626488BDBM50626488(CHEMBL5402552)
Affinity DataKi:  0.00500nMAssay Description:Binding affinity to C-terminal His6-tagged human recombinant CD73 in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527134BDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650167BDBM50650167(CHEMBL5631165)
Affinity DataKi:  0.00500nMAssay Description:Binding affinity to human recombinant CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527134BDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataKi:  0.00500nMAssay Description:Competitive reversible inhibition of human C-terminal His6-tagged CD73 expressed in HEK293 cells using AMP as substrate preincubated with substrate f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataKi:  0.0380nMAssay Description:Competitive inhibition of soluble C-terminal 6His-tagged recombinant human CD73 (27 to 547 residues) expressed in CHO cells assessed as inhibition co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataKi:  0.110nMAssay Description:Competitive inhibition of cell surface anchored CD73 (unknown origin) expressed in human SK-MEL-28 cells assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527135BDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.318nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527135BDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.318nMAssay Description:Binding affinity to human recombinant CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650169BDBM50650169(CHEMBL5624492)
Affinity DataKi:  0.318nMAssay Description:Binding affinity to human recombinant CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527135BDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.381nMAssay Description:Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583394BDBM50583394(CHEMBL5081267)
Affinity DataKi:  0.436nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583393BDBM50583393(CHEMBL5083600)
Affinity DataKi:  0.441nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583396BDBM50583396(CHEMBL5074970)
Affinity DataKi:  0.511nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583400BDBM50583400(CHEMBL5078828)
Affinity DataKi:  0.626nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583392BDBM50583392(CHEMBL5080841)
Affinity DataKi:  0.673nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527135BDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.746nMAssay Description:Inhibition of rat CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527135BDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.746nMAssay Description:Inhibition of recombinant rat CD73 expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640556BDBM50640556(CHEMBL5563097)
Affinity DataKi:  0.746nMAssay Description:Binding affinity to human recombinant N-terminal 6His-tagged CD73 (27 to 549 residues) expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583397BDBM50583397(CHEMBL5086866)
Affinity DataKi:  0.848nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378656BDBM50378656(CHEMBL598619)
Affinity DataKi:  0.870nMAssay Description:Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583389BDBM50583389(CHEMBL5076916)
Affinity DataKi:  0.894nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50368125BDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKi:  0.910nMAssay Description:Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583391BDBM50583391(CHEMBL5081442)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583395BDBM50583395(CHEMBL5084248)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583388BDBM50583388(CHEMBL5081604)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583386BDBM50583386(CHEMBL5094601)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583387BDBM50583387(CHEMBL5079813)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583399BDBM50583399(CHEMBL5076275)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583401BDBM50583401(CHEMBL5089752)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546335BDBM50546335(CHEMBL4755577)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human recombinant CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546335BDBM50546335(CHEMBL4755577)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650168BDBM50650168(CHEMBL5630200)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human recombinant CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583402BDBM50583402(CHEMBL5076684)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583403BDBM50583403(CHEMBL5070874)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561892BDBM50561892(CHEMBL4795486)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527131BDBM50527131(CHEMBL4585872)
Affinity DataKi:  3.30nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583390BDBM50583390(CHEMBL5093165)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527131BDBM50527131(CHEMBL4585872)
Affinity DataKi:  3.60nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523511BDBM50523511(CHEMBL4443977)
Affinity DataKi:  3.70nMAssay Description:Inhibition of CD73 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523511BDBM50523511(CHEMBL4443977)
Affinity DataKi:  3.70nMAssay Description:Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523526BDBM50523526(CHEMBL3606064)
Affinity DataKi:  4.5nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cell membranes using [2,8-3H]AMP as substrate measured after 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561892BDBM50561892(CHEMBL4795486)
Affinity DataKi:  4.60nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells using [2,8-3H]-AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523510BDBM50523510(CHEMBL4483379)
Affinity DataKi:  4.60nMAssay Description:Inhibition of recombinant human C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527138BDBM50527138(CHEMBL4475460)
Affinity DataKi:  4.60nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50437933BDBM50437933(CHEMBL2408703)
Affinity DataKi:  4.70nMAssay Description:Inhibition of rat Ecto-5'-nucleotidase transfected in COS7 cells preincubated for 10 mins followed by AMP addition measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2017
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523526BDBM50523526(CHEMBL3606064)
Affinity DataKi:  5.30nMAssay Description:Inhibition of recombinant human C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523510BDBM50523510(CHEMBL4483379)
Affinity DataKi:  5.70nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cell membranes using [2,8-3H]AMP as substrate measured after 25 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50527138BDBM50527138(CHEMBL4475460)
Affinity DataKi:  5.90nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
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