Compile Data Set for Download or QSAR
maximum 50k data
Found 65 Enz. Inhib. hit(s) with Target = 'A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]'
LigandPNGBDBM28339((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(7H-purin...)
Affinity DataIC50:  71nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28337((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...)
Affinity DataIC50:  73nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28327((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(3-methox...)
Affinity DataIC50:  78nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM28340((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(9H-purin...)
Affinity DataIC50:  170nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28326((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,...)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28332((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,4...)
Affinity DataIC50:  180nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28333((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(4H-1,2,4...)
Affinity DataIC50:  190nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28314((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxopyr...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28325((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxopip...)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28324((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,...)
Affinity DataIC50:  220nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28338((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[5-(meth...)
Affinity DataIC50:  230nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28334((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2H-1,2,3...)
Affinity DataIC50:  260nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28336((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,3...)
Affinity DataIC50:  270nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28335((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,3...)
Affinity DataIC50:  270nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28329((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)
Affinity DataIC50:  290nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28323((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2,5-diox...)
Affinity DataIC50:  310nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28331((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-imida...)
Affinity DataIC50:  320nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24019(1-benzyl-5-methyl-5'-(4-methylphenyl)-1,2-dihydro-...)
Affinity DataIC50:  610nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)
Affinity DataIC50:  640nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28328((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)
Affinity DataIC50:  750nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  780nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28330((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)
Affinity DataIC50:  820nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28316((1R,2S)-1-({[4-(4-chlorophenyl)-1,2,3,6-tetrahydro...)
Affinity DataIC50:  880nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50:  900nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24022(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-6-propyl-1,...)
Affinity DataIC50:  950nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28317((1R,2S)-1-{[6-(4-chlorophenyl)pyridine-3-][2-(2-ox...)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24018(5-methyl-1-(2-methylphenyl)-5'-(4-methylphenyl)-1,...)
Affinity DataIC50:  1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24013(6-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24012(5'-(4-methoxyphenyl)-6-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  1.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24004(5-ethyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24001(5'-(4-methylphenyl)-6-propyl-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24021(1-(4-chlorophenyl)-5'-(4-methoxyphenyl)-5-methyl-1...)
Affinity DataIC50:  1.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28313((2R)-2-{[4-(4-chlorophenyl)benzene][2-(2-oxopyrrol...)
Affinity DataIC50:  1.60E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24000(5-ethyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[...)
Affinity DataIC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24005(5-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24010(5-bromo-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  2.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24003(5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24016(1,5'-diphenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1...)
Affinity DataIC50:  2.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23999(5-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24015(5'-phenyl-1-(propan-2-yl)-1,2-dihydro-3'H-spiro[in...)
Affinity DataIC50:  3.10E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28306((2R)-2-{[4-(4-chlorophenyl)benzene]sulfonamido}-3-...)
Affinity DataIC50:  3.20E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23998(5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[indole-3...)
Affinity DataIC50:  3.70E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24011(5'-(4-methoxyphenyl)-5-nitro-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  4.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28319((1R,2S)-1-{[4-(4-acetamidophenyl)benzene][2-(2-oxo...)
Affinity DataIC50:  4.50E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24017(1-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  4.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28318((1R,2S)-1-({4-[4-(dimethylamino)phenyl]benzene}[2-...)
Affinity DataIC50:  6.60E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23997(5'-phenyl-5-(trifluoromethoxy)-1,2-dihydro-3'H-spi...)
Affinity DataIC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28312((2R)-2-{[4-(4-chlorophenyl)benzene](2-phenylethyl)...)
Affinity DataIC50:  7.30E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24020(5'-(4-methoxyphenyl)-1-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  7.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 65 total ) | Next | Last >>
Jump to: