Compile Data Set for Download or QSAR
Report error Found 3693 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1'
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataKd:  2.00E+4nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  120nMAssay Description:Compound was tested for inhibition of daunomycin efflux in the resistant human T-lymphoblast cell line CEM vcr1000.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  3.10E+3nMAssay Description:TP_TRANSPORTER: reversal of Vinblastine accumulation (Vinblastine: 0.005 uM) in MDA435/LCC6 MDR1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  1.04E+3nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009031(CHEMBL3237950)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009050(CHEMBL3237951)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009051(CHEMBL3233062)
Affinity DataEC50:  300nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009052(CHEMBL3237952)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009053(CHEMBL3237953)
Affinity DataEC50:  900nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009054(CHEMBL3237954)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009055(CHEMBL3237955)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009056(CHEMBL3237956)
Affinity DataEC50:  3.25E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009058(CHEMBL3237957)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009059(CHEMBL3237958)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009060(CHEMBL3237959)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009062(CHEMBL3237960)
Affinity DataEC50:  1.15E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009064(CHEMBL3237961)
Affinity DataEC50:  1.09E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50009065(CHEMBL3237962)
Affinity DataEC50:  4.37E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataEC50:  44nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50015306(CHEMBL3263842)
Affinity DataEC50:  27nMAssay Description:Stimulation of ATPase activity of ABCB1 (unknown origin) expressed in High Five insect cell membrane assessed as ATP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50021357(CHEMBL3288586)
Affinity DataEC50:  213nMAssay Description:Inhibition of p-glycoprotein in human MDA435/LCC6MDR cells assessed as concentration required to reduce taxol IC50 by half after 5 days by MTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50021358(CHEMBL3288595)
Affinity DataEC50:  211nMAssay Description:Inhibition of p-glycoprotein in human MDA435/LCC6MDR cells assessed as concentration required to reduce taxol IC50 by half after 5 days by MTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50095339(3,5,7-Trihydroxy-2-(4-iodo-phenyl)-chromen-4-one |...)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50095338(2-(4-Benzhydryl-phenyl)-3,5,7-trihydroxy-chromen-4...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50095340(2-(4-Fluoro-phenyl)-3,5,7-trihydroxy-chromen-4-one...)
Affinity DataKd:  6.80E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50049391(norizalpinin | 3,5,7-trihydroxy-2-phenyl-4H-benzop...)
Affinity DataKd:  5.90E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50095341(3,5,7-Trihydroxy-2-(4-octyl-phenyl)-chromen-4-one ...)
Affinity DataKd:  57nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM50095342(2-(2,4-Dichloro-phenyl)-3,5,7-trihydroxy-chromen-4...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Lyon 1

Curated by ChEMBL
LigandPNGBDBM7462(cid_5280863 | CHEMBL150 | 3,5,7-trihydroxy-2-(4-hy...)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111907(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111909(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111910(9-Chloro-3-methyl-5-{3-[2-(3,4,5-trimethoxy-phenox...)
Affinity DataEC50:  1.47E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111912(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111911(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.70E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111913(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.80E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111917(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111916(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111918(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  2.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111919(N-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.13E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111920(N-Benzo[1,3]dioxol-5-yl-2-[3-(9-chloro-3-methyl-4-...)
Affinity DataEC50:  4.00E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111921(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  4.10E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111915(LY-402913 | 2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxa...)
Affinity DataEC50:  900nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111914(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  1.30E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111922(2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]q...)
Affinity DataEC50:  3.20E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111923(9-Chloro-3-methyl-5-{3-[(3,4,5-trimethoxy-benzylam...)
Affinity DataEC50:  1.77E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111924(5-Methyl-isoxazole-3-carboxylic acid 3-(9-chloro-3...)
Affinity DataEC50:  7.90E+3nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111925(4-{2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50111926(5-Methyl-isoxazole-3-carboxylic acid [(1R,2R)-6-(9...)
Affinity DataEC50:  1.00E+4nMAssay Description:In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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