Compile Data Set for Download or QSAR
Report error Found 1125 Enz. Inhib. hit(s) with Target = 'Arginase'
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM130378(2(S)-amino-6-boronohexanoic acid (ABH))
Affinity DataKd:  1.30E+3nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM130379(N-hydroxy-L-arginine (NOHA))
Affinity DataKd:  330nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM130379(N-hydroxy-L-arginine (NOHA))
Affinity DataKd:  1.30E+4nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM130380(nor-N-hydroxy-L-arginine (nor-NOHA))
Affinity DataKd:  360nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM50427900(CHEMBL2326089 | (R)-2-amino-6-borono-2-[2-(piperid...)
Affinity DataKd:  260nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase(Blood fluke)
University of Pennsylvania

LigandPNGBDBM130381((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...)
Affinity DataKd:  540nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50316603(2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350309(CHEMBL1812662)
Affinity DataKd:  880nMAssay Description:Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350310(CHEMBL1812663)
Affinity DataKd:  3.40E+4nMAssay Description:Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human arginase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase(malaria parasite P. falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to Plasmodium falciparum arginaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  18nMAssay Description:Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50354832(CHEMBL1834160)
Affinity DataKd:  6.00E+4nMAssay Description:Displacement of [14C-guanidino]-L-arginine from human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to wild type human Arg I using L-arginine as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataKd:  47nMAssay Description:Binding affinity to arginase 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataKd:  270nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50230418(N-OMEGA-HYDROXY-L-ARGININE | Nomega-hydroxy-L-argi...)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataKd:  517nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577458(CHEMBL4858437)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577473(CHEMBL4871410)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577474(CHEMBL4876150)
Affinity DataEC50:  6.30E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577475(CHEMBL4855923)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577476(CHEMBL4852406)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577477(CHEMBL4868283)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577478(CHEMBL4872801)
Affinity DataEC50:  4.20E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577479(CHEMBL4862990)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50577480(CHEMBL4862982)
Affinity DataEC50:  2.80E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50052549(2-Amino-heptanedioic acid | CHEMBL111050)
Affinity DataKd:  3.00E+7nMAssay Description:Binding affinity to rat Arg IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50608140(CHEMBL1230498)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to human Arg IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350309(CHEMBL1812662)
Affinity DataKd:  880nMAssay Description:Binding affinity to human Arg I assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350310(CHEMBL1812663)
Affinity DataKd:  3.40E+4nMAssay Description:Binding affinity to human Arg I assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Inhibition of human Arginase I in human myeloid-derived suppressor cells using L-arginine as substrate assessed as L-ornithine product formation by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataKd:  50nMAssay Description:Inhibition of human Arginase I assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-2, mitochondrial(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561040(CHEMBL4754637)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561049(CHEMBL4793482)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561051(CHEMBL4749434)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561052(CHEMBL4755855)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561053(CHEMBL4750602)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50595723(CHEMBL5193387)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50595727(CHEMBL5184299)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50595729(CHEMBL5176739)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50595730(CHEMBL5171566)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetArginase-1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50595731(CHEMBL5170454)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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