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Report error Found 7324 Enz. Inhib. hit(s) with Target = 'Complement factor D'
TargetComplement factor D [24-253](Human)
Novartis Pharma

LigandPNGBDBM171272(1-(2-((1R,3S,5R)-3-(((R)-1-(3-Chloro-2-fluoropheny...)
Affinity DataKd:  6.03nMpH: 7.4 T: 2°CAssay Description:Single cycle kinetics (SCK): five increasing concentrations were injected successively without allowing for the dissociation of the protein-ligand co...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D [24-253](Human)
Novartis Pharma

LigandPNGBDBM171272(1-(2-((1R,3S,5R)-3-(((R)-1-(3-Chloro-2-fluoropheny...)
Affinity DataKd:  6.55nMpH: 7.4 T: 2°CAssay Description:Standard kinetics: an independent association-dissociation cycle was run for each concentration by injecting compound solution and waiting for dissoc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50332295(CHEMBL4176735)
Affinity DataKd:  6.80E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330772(CHEMBL4166600)
Affinity DataKd:  8.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataKd: <1nMAssay Description:Binding affinity to human factor D by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50332722(CHEMBL4171835)
Affinity DataKd: <1.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50236213(2-(3-Benzylureido)Benzoic Acid | CHEMBL561499)
Affinity DataKd:  5.00E+5nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50331392(CHEMBL4163988)
Affinity DataKd:  3.50E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50331097(CHEMBL4168539)
Affinity DataKd:  1.00E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50546245(CHEMBL4101312)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human CFD at 100 uM by WaterLOGSY NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330412(CHEMBL4161222)
Affinity DataKd:  8.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50332957(CHEMBL4169870)
Affinity DataKd:  1.70E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330953(CHEMBL4159632)
Affinity DataKd:  2.20E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50331395(CHEMBL4162063)
Affinity DataKd: >2.00E+6nMAssay Description:Binding affinity to 15-N labeled complement factor D (unknown origin) by 1H-15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50333109(CHEMBL4161639)
Affinity DataKd:  2.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to recombinant human 15-N labeled complement factor D catalytic domain (G24 to A253 residues) expressed in expressed in Escherichia ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50333118(CHEMBL4176751)
Affinity DataKd:  1.60E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50331093(CHEMBL4174337)
Affinity DataKd:  5.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to 15N-labeled human CFD by 1H-15N-HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to 15-N labeled complement factor D (unknown origin) by 1H-15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50201568(CHEMBL3951127)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50332017(CHEMBL4165382)
Affinity DataKd: >2.00E+6nMAssay Description:Binding affinity to 15-N labeled complement factor D (unknown origin) by 1H-15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50236214(CHEMBL4089211)
Affinity DataKd:  5.00E+5nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50333119(CHEMBL4170258)
Affinity DataKd:  1.20E+5nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50201569(CHEMBL3924715)
Affinity DataKd:  2.21E+3nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50333126(CHEMBL4170489)
Affinity DataKd:  1.00E+6nMAssay Description:Binding affinity to 15-N labeled complement factor D (unknown origin) by 1H-15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50330422(CHEMBL4176772)
Affinity DataKd:  5.00E+4nMAssay Description:Displacement of 19F[(S)-methyl 2-((2-(3-(trifluoromethoxy)phenylcarbamoyl)pyrrolidine-1-carboxamido)methyl)benzoate] from complement factor D (unknow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50201565(CHEMBL3941259)
Affinity DataKd:  17nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400274(CHEMBL2180765 | US9085555, 373)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400274(CHEMBL2180765 | US9085555, 373)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400273(CHEMBL2180764 | US9085555, 375)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400273(CHEMBL2180764 | US9085555, 375)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50446397(CHEMBL3109655)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM171262(US9085555, 692)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM171267(US9085555, 697)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM171305(US9085555, 735)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM171311(US9085555, 757 | US9085555, 741)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400275(CHEMBL2180766 | US9085555, 127)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM170738(US9085555, 166)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM170864(US9085555, 292)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM170890(US9085555, 318)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM170943(US9085555, 371)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM170945(US9085555, 374)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM254483(US9468661, 61)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM254486(US9468661, 64)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM254498(US9468661, 76 | US9468661, 109)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50446396(CHEMBL3109654)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50400275(CHEMBL2180766 | US9085555, 127)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human complement factor D after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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