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Report error Found 3559 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2C19'
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114568(CHEMBL3608913)
Affinity DataEC50:  4.64E+3nMAssay Description:Inhibition of human CYP2C19 by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114571(CHEMBL3608915)
Affinity DataEC50:  724nMAssay Description:Inhibition of human CYP2C19 by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114572(CHEMBL3608916)
Affinity DataEC50:  1.04E+3nMAssay Description:Inhibition of human CYP2C19 by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114573(CHEMBL3608920)
Affinity DataEC50:  2.94E+3nMAssay Description:Inhibition of human CYP2C19 by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114574(CHEMBL3608921)
Affinity DataEC50:  1.39E+4nMAssay Description:Inhibition of human CYP2C19 by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275432(S-2-(6-(1,4-dihydrobenzo[d][1,2]dioxine-6-sulfonam...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275377(S-2-(6-(4-(3-(dimethylamino)propoxy)phenylsulfonam...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50348709(CHEMBL1801062)
Affinity DataEC50:  2.70E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50348732(CHEMBL1801504)
Affinity DataEC50: >3.80E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50348733(CHEMBL1801060)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50448495(CHEMBL3126836)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50448496(CHEMBL3126835)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50448497(CHEMBL3126834)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50448494(CHEMBL3126657)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50246760(CHEMBL4075348)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50538668(CHEMBL4634455 | US11518761, Example 159)
Affinity DataEC50:  5.78E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50538669(CHEMBL4646408)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50538670(CHEMBL4642579)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50566257(CHEMBL4785210)
Affinity DataEC50: >3.30E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM31772(Brentan | 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dich...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of CYP2C19 in human liver Microsome using omeprazole as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM143355(US9682953, 20.A-1)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50136037(1-(4-Butoxy-phenyl)-1H-imidazole | CHEMBL112532)
Affinity DataIC50: 7nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50136037(1-(4-Butoxy-phenyl)-1H-imidazole | CHEMBL112532)
Affinity DataIC50: 7nMAssay Description:Inhibition of cytochrome P450 CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human CYP2C19 expressed in insect cell microsome after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50405759(CHEMBL5278512)
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM143373(US9682953, 20.A-10 | US9682953, 20.A-9)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM143362(US9682953, 20.A-5)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460773(CHEMBL4227082)
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50201124(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP2C19 in vitro by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM247368(US9447092, Comparator 2, Example 57)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM247371(US9447092, 1)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM247369(US9447092, 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50352206(CHEMBL1825089)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50552393(CHEMBL4779059)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50552388(CHEMBL4742065)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 33.6nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50384464(CHEMBL2036210)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant CYP2C19 incubated for 15 mins prior to substrate addition measured after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50113978(CHEMBL3605543)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50294698(4-((2-chlorobenzyl)(1-(1-methyl-1H-1,2,3-triazol-4...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50380531(CHEMBL2018917)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50136043(4-(4-Butoxy-phenyl)-pyrimidine | CHEMBL151974)
Affinity DataIC50: 46nMAssay Description:Inhibition of cytochrome P450 CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50136059(5-(4-Butoxy-phenyl)-1H-imidazole | CHEMBL151170)
Affinity DataIC50: 46nMAssay Description:Inhibition of cytochrome P450 CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50138236(2-Hexyloxy-5-imidazol-1-yl-pyridine | CHEMBL320105)
Affinity DataIC50: 46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50138233(2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine | ...)
Affinity DataIC50: 46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50138232(2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine | CHEMB...)
Affinity DataIC50: 46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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