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Found 22 Enz. Inhib. hit(s) with Target = 'Proteasome subunit alpha type-6'
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM588478((R)-N-(2,5-dichlorobenzoyl)-3- methylmercaptopropi...)
Affinity DataIC50:  4.86nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50516758(CHEMBL4444471 | US11542283, Compound V-9A)
Affinity DataIC50:  5.69nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM588482((R)-N-(2,5-dichlorobenzoyl)-3- methylmercaptopropi...)
Affinity DataIC50:  6.60nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50:  7.02nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50462621(CHEMBL1813256 | MLN-9708 | US11542283, Compound ML...)
Affinity DataIC50:  7.47nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50462625(CHEMBL4243375 | US11542283, Compound IV-8)
Affinity DataIC50:  7.52nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM588480((S)-N-(2,5-dichlorobenzoyl)-3- methoxypropionamido...)
Affinity DataIC50:  8.20nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  9.92nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65510(CPZ analog, 4)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65511(CPZ analog, 5)
Affinity DataEC50:  8.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65512(CPZ analog, 6)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65513(CPZ analog, 7)
Affinity DataEC50:  6.40E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65514(CPZ analog, 8)
Affinity DataEC50:  1.56E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65509(CPZ analog, 3)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65508(CPZ analog, 2)
Affinity DataEC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM65507(CPZ analog, 1)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataEC50:  9.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Affinity DataEC50:  1.24E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM79211(1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;h...)
Affinity DataEC50:  1.19E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataEC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataEC50:  1.48E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM67544(N,N-dimethyl-3-[2-(trifluoromethyl)-10-phenothiazi...)
Affinity DataEC50:  7.80E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed