Found 120 Enz. Inhib. hit(s) with Target = 'Sterol 14-alpha demethylase' 
Affinity DataIC50: 1nMAssay Description:Inhibition of Trypanosoma cruzi Sterol 14-alpha demethylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growt...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 52nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growt...More data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growt...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi Tulahuen C4 CYP51 expressed in Escherichia coli HMS174 using [3H]-sterol as substrate in presence of NADPH by reverse...More data for this Ligand-Target Pair
Affinity DataIC50: 4.87E+5nMAssay Description:Inhibition of Trypanosoma cruzi Tulahuen C4 CYP51 expressed in Escherichia coli HMS174 using [3H]-sterol as substrate in presence of NADPH by reverse...More data for this Ligand-Target Pair
Affinity DataKd: 440nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 750nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 240nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 290nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 7.60E+3nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 540nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 370nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 3.30E+3nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 560nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 260nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 2.31E+3nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 360nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 150nMpH: 7.4 T: 2°CAssay Description:As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th...More data for this Ligand-Target Pair
Affinity DataKd: 320nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 140nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 1.20E+3nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 130nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 380nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 110nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 90nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 50nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 110nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 20nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 230nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 60nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 110nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
Affinity DataKd: 19nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Affinity DataKd: 32nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Affinity DataKd: 18nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Affinity DataKd: 15nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Affinity DataKd: 4.80nMAssay Description:Binding affinity to Trypanosoma cruzi sterol 14alpha-demethylase by UV-SpectrophotometryMore data for this Ligand-Target Pair
TargetSterol 14-alpha demethylase cyp51A(Neosartorya fumigata (strain ATCC MYA-4609 / Af293...)
Swansea University
Curated by ChEMBL
Swansea University
Curated by ChEMBL
Affinity DataKd: 4.79E+3nMAssay Description:Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme A expressed in Escherichia coliMore data for this Ligand-Target Pair
