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Found 139 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ABL1 [T315I]'
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332702(US10196378, Compound C05)
Affinity DataKi: <1nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332700(US10196378, Compound C03)
Affinity DataKi: <1nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332698(US10196378, Compound C01)
Affinity DataKi: <1nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332699(US10196378, Compound C02)
Affinity DataKi: <1nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  2.10nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332703(US10196378, Compound C06)
Affinity DataKi:  4nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi:  119nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataIC50:  0.418nMpH: 7.5 T: 2°CAssay Description:Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataIC50:  0.551nMpH: 7.5 T: 2°CAssay Description:Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1nMT: 2°CAssay Description:Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM206084(US9255107, 3)
Affinity DataIC50:  2.12nMT: 2°CAssay Description:Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM206085(US9255107, 5)
Affinity DataIC50:  2.28nMT: 2°CAssay Description:Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50:  3nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614210(US11746110, Example 5)
Affinity DataIC50:  3.44nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614220(US11746110, Example 15)
Affinity DataIC50:  4.28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640359(Preparation of 3-((8-amino-3-ethylimidazo[1,5-a]py...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640361(Preparation of 3-((8-amino-3-methylimidazo[1,5-a]p...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640362(Preparation of 3-((8-amino-3-isopropylimidazo[1,5-...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640363(Preparation of 3-((4-amino-7-ethyl-7H-pyrrolo[2,3-...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640364(Preparation of 3-((4-amino-7-ethyl-7H-pyrrolo[2,3-...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640366(Preparation of 3-((4-amino-7-ethyl-7H-pyrrolo[2,3-...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640367(Preparation of 3-((4-amino-7-ethyl-7H-pyrrolo[2,3-...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640372(Preparation of 3-((4-amino-7-methyl-7H-pyrrolo[2,3...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640373(Preparation of 3-((4-amino-7-isopropyl-7H-pyrrolo[...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640374(Preparation of 3-((4-amino-7-methyl-7H-pyrrolo[2,3...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640375(Preparation of N-(3-((4-amino-7-ethyl-7H-pyrrolo[2...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640376(Preparation of N-(3-((4-amino-7-ethyl-7H-pyrrolo[2...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640377(Preparation of N-(3-((4-amino-7-methyl-7H-pyrrolo[...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640380(Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyc...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM640383(Preparation of N-(3-((4-amino-7-((1r,4r)-4-hydroxy...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM206087(US9255107, 9)
Affinity DataIC50:  6.45nMT: 2°CAssay Description:Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614213(US11746110, Example 8)
Affinity DataIC50:  6.47nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM206089(US9255107, 19)
Affinity DataIC50:  6.81nMT: 2°CAssay Description:Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614209(US11746110, Example 4)
Affinity DataIC50:  7.69nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM81734(PPY-A)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM81735(PPY-B)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614155(US11746110, Example 1)
Affinity DataIC50:  9.05nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614207(US11746110, Example 2)
Affinity DataIC50:  10.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614219(US11746110, Example 14)
Affinity DataIC50:  12.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM614214(US11746110, Example 9)
Affinity DataIC50:  19.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260153(US9522910, Table 1 Compound 3: 3-{2-[2-methyl-5-({...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260154(US9522910, Table 1 Compound 4: 3-{2-[2-methyl-5-({...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260155(US9522910, Table 1 Compound 5: 4-methyl-N-{4-[(4-m...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260156(US9522910, Table 1 Compound 6: 3-{2-[2-methyl-5-({...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260158(US9522910, Table 1 Compound 7: 3-{2-[2-methyl-5-({...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260151(US9522910, Table 1 Compound 1: 4-methyl-N-{4-[(4-m...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260152(US9522910, Table 1 Compound 2: 3-[2-(1H-1,3-benzod...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM260157(US9522910, Table 1 Compound 8: 4-fluoro-N-{4-[(4-m...)
Affinity DataIC50: <20nMAssay Description:Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I]/Breakpoint cluster region protein(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591906(CHEMBL5196374)
Affinity DataIC50:  25nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1 [T315I]/Breakpoint cluster region protein(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591899(CHEMBL5183677)
Affinity DataIC50:  25nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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