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Found 225 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase FRK'
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataKi:  4.72E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to human FRK using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of FRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184786(CHEMBL3824116 | US10294227, Code 565)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184777(CHEMBL3823104 | US10294227, Code 519)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184776(CHEMBL3824233 | US10294227, Code 518)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM387846(US10294227, Code 503)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM387836(US10294227, Code 585 | tert-butyl N-[4-[4-amino-1-...)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184777(CHEMBL3823104 | US10294227, Code 519)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184776(CHEMBL3824233 | US10294227, Code 518)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant PTK5 (218 to end residues) using GGEEEEYFELVKKKK as substrate incubated for 40 mins in presence of [gamma33P-ATP] by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50:  19nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  29nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataIC50:  32nMAssay Description:Inhibition of human PTK5 in presence of ATP by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  34nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50:  36nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant FrkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50560327(CHEMBL4749037)
Affinity DataIC50:  46nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50563891(CHEMBL4793380)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant human PTK5 (218 to end residues) using GGEEEEYFELVKKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM473171((3R,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50:  52nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50:  53nMAssay Description:Inhibition of FRK (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184785(CHEMBL3823620 | US10294227, Code 553)
Affinity DataIC50:  55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184785(CHEMBL3823620 | US10294227, Code 553)
Affinity DataIC50:  55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  62nMAssay Description:Inhibition of GST-tagged full length human recombinant FRK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50:  85nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM267790(4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50269555(CHEMBL4060757)
Affinity DataIC50:  132nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM267959(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50:  151nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM255338(US9481682, 116 | US9481682, 88)
Affinity DataIC50:  154nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50558112(CHEMBL4799627)
Affinity DataIC50:  187nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)
Affinity DataIC50:  214nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM267703((R)-4-(8-amino-5-deutero-3-(1-(3-methoxypropanoyl)...)
Affinity DataIC50:  361nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50:  379nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50:  379nMAssay Description:Inhibition of human FRK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50269557(CHEMBL4069387)
Affinity DataIC50:  472nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged FRK (218 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  530nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184769(CHEMBL3823212 | US10294227, Code 109)
Affinity DataIC50:  550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184766(CHEMBL3823861 | US10294227, Code 221)
Affinity DataIC50:  550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM387845(US10294227, Code 402)
Affinity DataIC50:  550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50184781(CHEMBL3823543 | US10294227, Code 533)
Affinity DataIC50:  550nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
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