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Found 1663 Enz. Inhib. hit(s) with Target = 'cAMP-dependent protein kinase'
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50599153(CHEMBL5196521)
Affinity DataKi:  0.00700nMAssay Description:Covalent inhibition of human recombinant PKAC-alpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50599152(CHEMBL5179794)
Affinity DataKi:  0.0230nMAssay Description:Covalent inhibition of human recombinant PKAC-alpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50599149(CHEMBL5174535)
Affinity DataKi:  0.630nMAssay Description:Covalent inhibition of human recombinant PKAC-alpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM36603(4'',6''-Dideoxybalanol, 6)
Affinity DataKi:  3.40nM ΔG°:  -49.1kJ/mole IC50:  5.5nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM36604(5'-Deoxybalanol, 7)
Affinity DataKi:  3.5nM ΔG°:  -49.1kJ/mole IC50:  5.70nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM3207(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Affinity DataKi:  3.90nM ΔG°:  -48.8kJ/mole IC50:  6.30nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Homo sapiens (Human))
Ura Cnrs 1309

Curated by ChEMBL
LigandPNGBDBM50228843(CHEMBL436718)
Affinity DataKi:  4nMAssay Description:Displacement of ATP from protein kinase A (PKA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50599151(CHEMBL5172486)
Affinity DataKi:  4.20nMAssay Description:Covalent inhibition of human recombinant PKAC-alpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataKi:  4.70nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM36602(14''-Decarboxybalanol hydrochloride, 5)
Affinity DataKi:  11nM ΔG°:  -46.2kJ/mole IC50:  18nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Abbott Laboratories

LigandPNGBDBM15138(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50525586(CHEMBL4457150)
Affinity DataKi:  30nMAssay Description:Inhibition of protein kinase A (unknown origin) using Kemptide (LRRASLG) as substrate incubated for 15 mins in presence of ATP by spectrophotometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310470(4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataKi:  34nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKi:  35nMpH: 7.5Assay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  48nM ΔG°:  -42.5kJ/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM36606(H-89, 10)
Affinity DataKi:  48nMpH: 7.5Assay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM36605(KT5720, 9)
Affinity DataKi:  56nMpH: 7.5Assay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50525584(CHEMBL4453941)
Affinity DataKi:  110nMAssay Description:Inhibition of protein kinase A (unknown origin) using Kemptide (LRRASLG) as substrate incubated for 15 mins in presence of ATP by spectrophotometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097152(CHEMBL3581149)
Affinity DataKi:  140nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Homo sapiens (Human))
Ura Cnrs 1309

Curated by ChEMBL
LigandPNGBDBM50228839(CHEMBL415414)
Affinity DataKi:  170nMAssay Description:Displacement of ATP from protein kinase A (PKA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50067533(CHEMBL3401984)
Affinity DataKi:  230nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097177(CHEMBL3581126)
Affinity DataKi:  310nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  340nM ΔG°:  -37.5kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM92607(H-88)
Affinity DataKi:  360nM ΔG°:  -37.4kJ/moleT: 2°CAssay Description:Protein kinase C, cAMP dependent protein kinase, cGMP dependent protein kinase and myosin light chain kinase activity were measure under conditions d...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310459(4-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  380nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  460nM ΔG°:  -36.8kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50067531(CHEMBL3401983)
Affinity DataKi:  490nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097169(CHEMBL3581135)
Affinity DataKi:  500nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097172(CHEMBL3581131)
Affinity DataKi:  520nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310456(4-(1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)
Affinity DataKi:  540nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50462713(CHEMBL4242549)
Affinity DataKi:  580nMAssay Description:Inhibition of PKAalpha (1 to 351 residues) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase-lactate dehydrogenase c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50067515(CHEMBL3401979)
Affinity DataKi:  590nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310458(4-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)
Affinity DataKi:  600nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097155(CHEMBL3581132)
Affinity DataKi:  600nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310457(4-(1-cyclopentyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)
Affinity DataKi:  720nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097165(CHEMBL3581146)
Affinity DataKi:  780nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097153(CHEMBL3581150)
Affinity DataKi:  850nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50168588(4-(1-Ethyl-1H-benzoimidazol-2-yl)-furazan-3-ylamin...)
Affinity DataKi:  960nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097170(CHEMBL3581134)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of PKAalpha (1 to 351 amino acids) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase/lactate dehydrogenas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310461(4-(1-isobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxad...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50067538(CHEMBL3401988)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University Of California San Diego

LigandPNGBDBM15210(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory constant against cAPK (PKA)More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310476(4-(1-isobutyl-4-phenyl-1H-imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310462(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadia...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310460(4-(1-(cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50097154(CHEMBL3581121)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of PKAalpha (1 to 351 residues) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase-lactate dehydrogenase c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.49E+3nMAssay Description:Inhibition of PRKXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50067540(CHEMBL3401990)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
University Of Tartu

Curated by ChEMBL
LigandPNGBDBM50310475((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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