Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with Target = '5'-AMP-activated protein kinase subunit beta-1'
LigandPNGBDBM50600527(CHEMBL5201587)
Affinity DataEC50:  800nMAssay Description:Activation of rat liver AMPK-beta1 using SAMS peptide as substrate incubated for 10 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 9 alpha2/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195479(CHEMBL3950376)
Affinity DataEC50: <500nMAssay Description:Activation of human recombinant AMPK beta1 expressed in African green monkey COS7 cells or baculovirus infected insect cells assessed as increase in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50195477(CHEMBL3979403)
Affinity DataEC50:  0.700nMAssay Description:Activation of recombinant human His-tagged AMPK alpha2 (2 to 552 residues)/beta1 (2 to 270 residues)/gamma2 (2 to 569 residues) expressed in baculovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434751(CHEMBL2385579)
Affinity DataIC50: 40nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434748(CHEMBL2385600)
Affinity DataIC50: 44nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434749(CHEMBL2385586)
Affinity DataIC50: 82nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 235nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 235nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 318nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataIC50: 400nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM238079(US9394285, 173)
Affinity DataIC50: 420nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 527nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434750(CHEMBL2385596)
Affinity DataIC50: 960nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM160333(US9040694, 5)
Affinity DataIC50: 1.12E+3nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.12E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 1.94E+3nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 1.94E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM102618(LDN-212854)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434752(CHEMBL2385582)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataIC50: 2.92E+3nMAssay Description:Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 3.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50262016(4-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Affinity DataIC50: 7.26E+3nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataIC50: 8.04E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50429867(CHEMBL2333365)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463100(CHEMBL4249790)
Affinity DataIC50: 1.10E+4nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463101(CHEMBL4250253)
Affinity DataIC50: 2.50E+4nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50380246(CHEMBL2017214)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of AMPKB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50402020(CHEMBL2205426)
Affinity DataKi:  333nMAssay Description:Inhibition of recombinant AMPK after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  1.54E+3nMAssay Description:Inhibition of AMPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed