Compile Data Set for Download or QSAR
Report error Found 145 Enz. Inhib. hit(s) with Target = 'Acetylcholine receptor subunit alpha/beta/delta/gamma'
LigandPNGBDBM86544(NSC_6442277 | CAS_192231-16-6 | CHEMBL111580 | SIB...)
Affinity DataEC50:  5.20E+4nMAssay Description:The compound was tested on recombinant human alpha-1-beta-1-gamma-delta cell lines of human embryonic kidney for nicotinic acetylcholine receptor ago...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM86544(NSC_6442277 | CAS_192231-16-6 | CHEMBL111580 | SIB...)
Affinity DataEC50:  5.30E+4nMAssay Description:The compound was tested on recombinant human alpha-1-beta-1-gamma-delta cell lines of human embryonic kidney for nicotinic acetylcholine receptor ago...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  200nMAssay Description:Functional potency for nAChR subtype Alpha-1-beta-1-delta gamma (torpedo)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50035398(ABT-418 | (S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-...)
Affinity DataEC50:  4.11E+5nMAssay Description:Functional potency for nAChR subtype Alpha1-beta1 delta gamma (torpedo)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  6.00E+4nMAssay Description:Functional potency for nAChR subtype Alpha-1-beta-1-delta gamma(torpedo)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50038413(N1,N6-bis(2,3-dihydroxybenzyl)-N1,N1,N6,N6-tetrame...)
Affinity DataKd:  18nMAssay Description:Compound was evaluated for the binding constant for association with nicotinic acetylcholine receptor (nAChR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50038414(N1,N10-bis(2,3-dihydroxybenzyl)-N1,N1,N10,N10-tetr...)
Affinity DataKd:  230nMAssay Description:Compound was evaluated for the binding constant for association with nicotinic acetylcholine receptor (nAChR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50038416(Hexamethoniumdibromide | N,N,N,N'',N'',N''-Hexamet...)
Affinity DataKd:  1.80E+3nMAssay Description:Compound was evaluated for the binding constant for association with nicotinic acetylcholine receptor (nAChR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50161084(1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161087(9,11-Diiodo-1,2,3,4,5,6-hexahydro-1,5-methano-pyri...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161088(11-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161086(9-Iodo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,...)
Affinity DataEC50:  45nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161089(11-Chloro-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  0.0530nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161083(11,11-dimethyl-6-oxo-7-aza-11-azoniatricyclo[7.3.1...)
Affinity DataEC50:  37nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161090(9-Chloro-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[...)
Affinity DataEC50:  28nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50143282((1R,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataEC50:  11nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161092(9,11-Dichloro-1,2,3,4,5,6-hexahydro-1,5-methano-py...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161091(9,11-Dibromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyr...)
Affinity DataEC50: >100nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50161085(9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1...)
Affinity DataEC50:  31nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000690(Tubocurarine,d | 10,25-dimethoxy-15,15,30-trimethy...)
Affinity DataEC50:  3.20E+6nMAssay Description:In vitro ability to inhibit the binding of [125I]-alpha-bungarotoxin to nicotinic acetylcholine receptor on membranes prepared from the electric orga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50210332(CHEMBL3889475)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210333(CHEMBL3908556)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210338(CHEMBL3926480)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210335(CHEMBL3898434)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210337(CHEMBL3970672)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210334(CHEMBL3948977)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
LigandPNGBDBM50210336(CHEMBL3899499)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at alpha1beta1gammadelta nAChR in human TE671/RD cells after 9.5 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023330(Anatoxin-a | Anatoxin-A,(+) | CHEMBL25619 | 1-(9-a...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023331(4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023330(Anatoxin-a | Anatoxin-A,(+) | CHEMBL25619 | 1-(9-a...)
Affinity DataIC50: 1nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023331(4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-...)
Affinity DataIC50: 1nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 4nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Rat)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50547500(CHEMBL4759352)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of rat (alpha1)2betagammadelta expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced channel current respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023328(Nornicotine | 3-Pyrrolidin-2-yl-pyridine | CHEMBL1...)
Affinity DataIC50: 100nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023327(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)
Affinity DataIC50: 300nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023327(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023328(Nornicotine | 3-Pyrrolidin-2-yl-pyridine | CHEMBL1...)
Affinity DataIC50: 300nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50094299(N-[(S)-1-(12-Amino-dodecylcarbamoyl)-2-(4-hydroxy-...)
Affinity DataIC50: 790nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023329(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)
Affinity DataIC50: 800nMAssay Description:inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50023329(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of [3H]MCC binding to torpedo electroplax membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50473035(CHEMBL342483)
Affinity DataIC50: 2.43E+3nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473033(CHEMBL342258)
Affinity DataIC50: 4.47E+3nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473023(CHEMBL342235)
Affinity DataIC50: 5.33E+3nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473029(CHEMBL140056)
Affinity DataIC50: 5.69E+3nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50322520((2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2...)
Affinity DataIC50: 5.90E+3nMAssay Description:Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322515((2S,3S)-2-(Naphthalen-1-yl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 6.60E+3nMAssay Description:Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322516((+/-)2-(3,5-Dichlorophenyl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 7.20E+3nMAssay Description:Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322518((+/-)2-(3,4-Dichlorophenyl)-3,5,5-trimethylmorphol...)
Affinity DataIC50: 7.20E+3nMAssay Description:Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
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