Compile Data Set for Download or QSAR
Found 306 Enz. Inhib. hit(s) with Target = 'Acid ceramidase'
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Show SMILES CC(C)CNC(=O)n1c2ccc(cc2oc1=O)C1CCN(C)CC1
Show InChI InChI=1S/C18H25N3O3/c1-12(2)11-19-17(22)21-15-5-4-14(10-16(15)24-18(21)23)13-6-8-20(3)9-7-13/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,19,22)
Affinity DataKi:  0.150nMAssay Description:Time-dependent inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2ccccc2oc1=O
Show InChI InChI=1S/C18H18N2O3/c21-17(19-13-7-6-10-14-8-2-1-3-9-14)20-15-11-4-5-12-16(15)23-18(20)22/h1-5,8-9,11-12H,6-7,10,13H2,(H,19,21)
Affinity DataKi:  64nMAssay Description:Non-competitive inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM29080(CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
Affinity DataKi:  5.00E+5nMAssay Description:Inhibition of acid ceramidase (unknown origin)More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)
Affinity DataIC50: 0.800nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238556(CHEMBL4093029)
Show SMILES Nc1nc2ccccc2n1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C18H20N4O/c19-17-21-15-11-4-5-12-16(15)22(17)18(23)20-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H2,19,21)(H,20,23)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238557(CHEMBL4103207)
Show SMILES Cc1nc2ccccc2n1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-15-21-17-12-5-6-13-18(17)22(15)19(23)20-14-8-7-11-16-9-3-2-4-10-16/h2-6,9-10,12-13H,7-8,11,14H2,1H3,(H,20,23)
Affinity DataIC50: 1nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367226(4-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES Fc1cccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c12
Show InChI InChI=1S/C18H17FN2O3/c19-14-10-6-11-15-16(14)21(18(23)24-15)17(22)20-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,22)
Affinity DataIC50: 1nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238562(CHEMBL4084295)
Show SMILES O=C(NCCCCc1ccccc1)n1nnc2ncccc12
Show InChI InChI=1S/C16H17N5O/c22-16(21-14-10-6-12-17-15(14)19-20-21)18-11-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10,12H,4-5,9,11H2,(H,18,22)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238574(CHEMBL4092051)
Show SMILES O=C(NCCCCc1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C17H18N4O/c22-17(21-16-12-5-4-11-15(16)19-20-21)18-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H,18,22)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238573(CHEMBL4062592)
Show SMILES CCCCCCNC(=O)n1nnc2ncccc12
Show InChI InChI=1S/C12H17N5O/c1-2-3-4-5-8-14-12(18)17-10-7-6-9-13-11(10)15-16-17/h6-7,9H,2-5,8H2,1H3,(H,14,18)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238569(CHEMBL4075447)
Show SMILES O=C(NCCCCc1ccccc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H18N2O3/c22-17-15-11-4-5-12-16(15)18(23)21(17)19(24)20-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H,20,24)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238572(CHEMBL4065362)
Show SMILES CCCCCCNC(=O)n1c(N)nc2ccccc12
Show InChI InChI=1S/C14H20N4O/c1-2-3-4-7-10-16-14(19)18-12-9-6-5-8-11(12)17-13(18)15/h5-6,8-9H,2-4,7,10H2,1H3,(H2,15,17)(H,16,19)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238568(CHEMBL4100744)
Show SMILES O=C(NCCCCc1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C18H19N3O/c22-18(21-14-20-16-11-4-5-12-17(16)21)19-13-7-6-10-15-8-2-1-3-9-15/h1-5,8-9,11-12,14H,6-7,10,13H2,(H,19,22)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50511300(CHEMBL4580541)
Show SMILES O=C(NCCCCc1ccccc1)n1c2ccncc2oc1=O
Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-9-11-18-12-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)
Affinity DataIC50: 3nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
Affinity DataIC50: 3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
Affinity DataIC50: 3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431244(CHEMBL2333064)
Show SMILES CCCCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O
Show InChI InChI=1S/C15H22FN3O5/c1-3-4-5-6-7-8-9-17-13(21)18-10-11(16)12(20)19(14(18)22)15(23)24-2/h10H,3-9H2,1-2H3,(H,17,21)
Affinity DataIC50: 4nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238578(CHEMBL4071239)
Show SMILES CCCCCCNC(=O)n1nnc2ccccc12
Show InChI InChI=1S/C13H18N4O/c1-2-3-4-7-10-14-13(18)17-12-9-6-5-8-11(12)15-16-17/h5-6,8-9H,2-4,7,10H2,1H3,(H,14,18)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238558(CHEMBL4075028)
Show SMILES O=C(NCCCCc1ccccc1)n1ncc2ccccc12
Show InChI InChI=1S/C18H19N3O/c22-18(21-17-12-5-4-11-16(17)14-20-21)19-13-7-6-10-15-8-2-1-3-9-15/h1-5,8-9,11-12,14H,6-7,10,13H2,(H,19,22)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50556798(CHEMBL4742096)
Show SMILES Clc1ccc(cc1)-c1coc(=O)n1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C20H19ClN2O3/c21-17-11-9-16(10-12-17)18-14-26-20(25)23(18)19(24)22-13-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-12,14H,4-5,8,13H2,(H,22,24)
Affinity DataIC50: 5nMAssay Description:Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50511282(CHEMBL4592427)
Show SMILES O=C(NCCCCc1ccccc1)n1c2cnccc2oc1=O
Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-12-18-11-9-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)
Affinity DataIC50: 6nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238563(Benzoimidazole-1-Carboxylic Acid Hexylamide | CHEM...)
Show SMILES CCCCCCNC(=O)n1cnc2ccccc12
Show InChI InChI=1S/C14H19N3O/c1-2-3-4-7-10-15-14(18)17-11-16-12-8-5-6-9-13(12)17/h5-6,8-9,11H,2-4,7,10H2,1H3,(H,15,18)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238570(CHEMBL4089655)
Show SMILES CCCCCCNC(=O)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C15H18N2O3/c1-2-3-4-7-10-16-15(20)17-13(18)11-8-5-6-9-12(11)14(17)19/h5-6,8-9H,2-4,7,10H2,1H3,(H,16,20)
Affinity DataIC50: 7nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238577(CHEMBL4096883)
Show SMILES Cc1ccc(CNC(=O)n2c(N)nc3ccccc23)cc1
Show InChI InChI=1S/C16H16N4O/c1-11-6-8-12(9-7-11)10-18-16(21)20-14-5-3-2-4-13(14)19-15(20)17/h2-9H,10H2,1H3,(H2,17,19)(H,18,21)
Affinity DataIC50: 7nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431255(CHEMBL2333053)
Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O
Show InChI InChI=1S/C13H18FN3O5/c1-3-4-5-6-7-15-11(19)16-8-9(14)10(18)17(12(16)20)13(21)22-2/h8H,3-7H2,1-2H3,(H,15,19)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431246(CHEMBL2333062 | US9428465, 32)
Show SMILES CCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C14H20F3N3O3/c1-2-3-4-5-6-7-8-18-12(22)20-9-10(14(15,16)17)11(21)19-13(20)23/h9H,2-8H2,1H3,(H,18,22)(H,19,21,23)
Affinity DataIC50: 7nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431246(CHEMBL2333062 | US9428465, 32)
Show SMILES CCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C14H20F3N3O3/c1-2-3-4-5-6-7-8-18-12(22)20-9-10(14(15,16)17)11(21)19-13(20)23/h9H,2-8H2,1H3,(H,18,22)(H,19,21,23)
Affinity DataIC50: 7nMpH: 4.5Assay Description:r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50431253(CHEMBL2333055)
Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O
Show InChI InChI=1S/C16H24FN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238576(CHEMBL4076230)
Show SMILES Cc1cccc(CNC(=O)n2cnc3ccccc23)c1
Show InChI InChI=1S/C16H15N3O/c1-12-5-4-6-13(9-12)10-17-16(20)19-11-18-14-7-2-3-8-15(14)19/h2-9,11H,10H2,1H3,(H,17,20)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238561(CHEMBL4101140)
Show SMILES Cc1cccc(CNC(=O)n2c(N)nc3ccccc23)c1
Show InChI InChI=1S/C16H16N4O/c1-11-5-4-6-12(9-11)10-18-16(21)20-14-8-3-2-7-13(14)19-15(20)17/h2-9H,10H2,1H3,(H2,17,19)(H,18,21)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367187(5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES Clc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17ClN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)
Affinity DataIC50: 9nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM319796(US10174015, Compound 9)
Show SMILES Clc1cccc(CCCCCC(=O)N2CCOC2=O)c1
Show InChI InChI=1S/C15H18ClNO3/c16-13-7-4-6-12(11-13)5-2-1-3-8-14(18)17-9-10-20-15(17)19/h4,6-7,11H,1-3,5,8-10H2
Affinity DataIC50: 9nMAssay Description:Inhibition of rat acid ceramidase expressed in HEK293 cells using N-lauroylceramide as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50238565(CHEMBL4095461)
Show SMILES CCCCCCNC(=O)n1ncc2ccccc12
Show InChI InChI=1S/C14H19N3O/c1-2-3-4-7-10-15-14(18)17-13-9-6-5-8-12(13)11-16-17/h5-6,8-9,11H,2-4,7,10H2,1H3,(H,15,18)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431271(CHEMBL2333033 | US9428465, 4)
Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)
Affinity DataIC50: 10nMpH: 4.5Assay Description:r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367186(6-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES Fc1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C18H17FN2O3/c19-14-9-10-15-16(12-14)24-18(23)21(15)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)
Affinity DataIC50: 10nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367196(2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...)
Show SMILES FC(F)(F)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)14-9-10-16-15(12-14)24(18(26)27-16)17(25)23-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,23,25)
Affinity DataIC50: 11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367198(5-cyano-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2cc(ccc2oc1=O)C#N
Show InChI InChI=1S/C19H17N3O3/c20-13-15-9-10-17-16(12-15)22(19(24)25-17)18(23)21-11-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,21,23)
Affinity DataIC50: 11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431271(CHEMBL2333033 | US9428465, 4)
Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431271(CHEMBL2333033 | US9428465, 4)
Show SMILES CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C12H16F3N3O3/c1-2-3-4-5-6-16-10(20)18-7-8(12(13,14)15)9(19)17-11(18)21/h7H,2-6H2,1H3,(H,16,20)(H,17,19,21)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat acid ceramidaseMore data for this Ligand-Target Pair
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431254(CHEMBL2333054)
Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC)c1=O
Show InChI InChI=1S/C14H20FN3O5/c1-3-5-6-7-8-16-12(20)17-9-10(15)11(19)18(13(17)21)14(22)23-4-2/h9H,3-8H2,1-2H3,(H,16,20)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367185(5-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES Fc1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17FN2O3/c19-14-9-10-16-15(12-14)21(18(23)24-16)17(22)20-11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,20,22)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Rattus norvegicus (Rat))
Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50431260(CHEMBL2333048)
Show SMILES CCCCCCNC(=O)n1cc(F)c(=O)n(C)c1=O
Show InChI InChI=1S/C12H18FN3O3/c1-3-4-5-6-7-14-11(18)16-8-9(13)10(17)15(2)12(16)19/h8H,3-7H2,1-2H3,(H,14,18)
Affinity DataIC50: 13nMAssay Description:Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50556790(CHEMBL4777626)
Show SMILES CCCCCCNC(=O)n1cc(Cl)c(=O)n(C(=O)OCC(C)C)c1=O
Show InChI InChI=1S/C16H24ClN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)
Affinity DataIC50: 13nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50556791(CHEMBL4754069)
Show SMILES CCCCCCNC(=O)n1nc(C)cc1C(F)(F)F
Show InChI InChI=1S/C12H18F3N3O/c1-3-4-5-6-7-16-11(19)18-10(12(13,14)15)8-9(2)17-18/h8H,3-7H2,1-2H3,(H,16,19)
Affinity DataIC50: 14nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Show SMILES Clc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C25H21ClN2O4/c26-20-12-9-18(10-13-20)23(29)19-11-14-21-22(16-19)32-25(31)28(21)24(30)27-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,27,30)
Affinity DataIC50: 14nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Show SMILES Clc1ccc(cc1)C(=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C25H21ClN2O4/c26-20-12-9-18(10-13-20)23(29)19-11-14-21-22(16-19)32-25(31)28(21)24(30)27-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,27,30)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid ceramidase(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM241946(US9428465, 24)
Show SMILES CCCCCCNC(=O)n1cc(Br)c(=O)n(C(=O)OCC(C)C)c1=O
Show InChI InChI=1S/C16H24BrN3O5/c1-4-5-6-7-8-18-14(22)19-9-12(17)13(21)20(15(19)23)16(24)25-10-11(2)3/h9,11H,4-8,10H2,1-3H3,(H,18,22)
Affinity DataIC50: 14nMpH: 4.5Assay Description:A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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