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Report error Found 73 Enz. Inhib. hit(s) with Target = 'Acid-sensing ion channel 3'
TargetAcid-sensing ion channel 3(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50548045(CHEMBL4757433)
Affinity DataEC50:  3.00E+3nMAssay Description:Modulation of rat ASIC3 expressed in Xenopus laevis oocytes at -70 mV holding potential by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348097(CHEMBL1800440)
Affinity DataIC50: 190nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348098(CHEMBL1800430)
Affinity DataIC50: 220nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348111(CHEMBL1800436)
Affinity DataIC50: 230nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348107(CHEMBL1800432)
Affinity DataIC50: 230nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348104(CHEMBL1800428)
Affinity DataIC50: 270nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348113(CHEMBL1800433)
Affinity DataIC50: 310nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348099(CHEMBL1800331)
Affinity DataIC50: 460nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259583(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Affinity DataIC50: 490nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259353(3-amino-6-chloro-N-(diaminomethylene)-5-(naphthale...)
Affinity DataIC50: 510nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348095(CHEMBL1800437)
Affinity DataIC50: 510nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259584(3-amino-N-(diaminomethylene)-5-(3-(thiophen-3-yl)p...)
Affinity DataIC50: 640nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348106(CHEMBL1800431)
Affinity DataIC50: 680nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50259583(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Affinity DataIC50: 950nMAssay Description:Inhibition of rat ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342661(2-(3-(phenylethynyl)phenyl)pyridin-4-amine | CHEMB...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342642(6-(6-(2-methylpiperidin-1-yl)pyridin-2-yl)-1,2,3,4...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348112(CHEMBL1800438)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342660(4-(3-(4-aminopyridin-2-yl)phenyl)but-3-yn-1-ol | C...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348103(CHEMBL1800427)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342647(6-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342641(6-(3,5-dichlorophenyl)-1,2,3,4-tetrahydroisoquinol...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348102(CHEMBL1800334)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342649(6-methyl-N-(4-(6-(piperazin-1-yl)pyridin-3-yl)phen...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348096(CHEMBL1800439)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348101(CHEMBL1800333)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342662(2-phenyl-6-(pyridin-2-ylmethyl)pyridin-4-amine | C...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348100(CHEMBL1800332)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342659(2-phenylpyridin-4-amine | CHEMBL1770738)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342643(6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydrois...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342651(N-(6-methylpyridin-2-yl)furo[2,3-c]pyridin-7-amine...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50157090(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of ASIC3 in rat DRG neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342650(4-amino-N-(4-chlorophenethyl)-2-propylquinoline-6-...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348108(CHEMBL1800434)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342640(6-bromo-2-((5-methoxy-1H-indol-3-yl)methyl)-1,2,3,...)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342646(6-(4-(4-methylpiperazin-1-yl)phenyl)-1,2,3,4-tetra...)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342648(2-methyl-4-(4-(6-methylpyridin-2-ylamino)phenyl)bu...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348110(CHEMBL1800079)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342645(6-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342663(4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-meth...)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348109(CHEMBL1800435)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348105(CHEMBL1800429)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296576(2-(3-chloro-5-methylphenyl)-1H-indole-5-carboximid...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296571(2-(3,5-dibromophenyl)-1H-indole-5-carboximidamide ...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296570(2-(3-bromo-5-fluorophenyl)-1H-indole-5-carboximida...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296575(2-(3-(benzylamino)-5-chlorophenyl)-1H-indole-5-car...)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296573(2-(3-amino-5-chlorophenyl)-1H-indole-5-carboximida...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342644(2-((5-methoxy-1H-indol-3-yl)methyl)-6-(3-(trifluor...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296574(2-(3-chloro-5-((phenylamino)methyl)phenyl)-1H-indo...)
Affinity DataIC50: 1.14E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
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