Compile Data Set for Download or QSAR
Report error Found 134 Enz. Inhib. hit(s) with Target = 'Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor'
LigandPNGBDBM50497037(CHEMBL3248387)
Affinity DataKd:  141nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497038(CHEMBL3248388)
Affinity DataKd:  562nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497039(CHEMBL3248383)
Affinity DataKd:  617nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497040(CHEMBL3248386)
Affinity DataKd:  1.02E+3nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497041(CHEMBL3248385)
Affinity DataKd:  309nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  1.50E+4nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataIC50: 16nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataIC50: 17nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration required for displacement of Alpha adrenergic receptor specific ligand, 2-[ [ [(2,6-dimethoxyphenoxy) ethyl]amino]methyl]ben...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
LigandPNGBDBM50027226(3-Methyl-1,2,3,4,4a,8-hexahydro-7-thia-3,12b-diaza...)
Affinity DataIC50: 300nMAssay Description:In vitro binding affinity towards alpha-adreno ceptor of rat forebrain using [3H]prazosinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50225364(CHEMBL43319)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against alpha adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50045855(2-(6,7-Dihydro-5H-benzo[3,4]azepino[1,2-a]indol-13...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045890({2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-ethyl}-dihe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045891(2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045881(N-(2-Bromo-phenyl)-2-[2-(4-fluoro-phenyl)-1H-indol...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045875(2-Phenyl-1,5-dihydro-3H-pyrrolo[4,3,2-de]quinolin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045890({2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-ethyl}-dihe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045880(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045868(2-(6-Fluoro-2-phenyl-1H-indol-3-yl)-N,N-dipropyl-a...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045872(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N,N-dihexyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045892(2-[5-Chloro-2-(4-fluoro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045888(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-N-hexyl-acet...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045896(2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045854(3-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-2-phenyl-1H...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045864(2-[2-(4-Chloro-phenyl)-1-methyl-1H-indol-3-yl]-N,N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045886(3-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045867(N,N-Dibutyl-2-[2-(4-fluoro-phenyl)-1H-indol-3-yl]-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045865(2-(2-Phenyl-1H-indol-3-yl)-1-piperidin-1-yl-ethano...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045862(2-(2-Phenyl-1H-indol-3-yl)-1-pyrrolidin-1-yl-ethan...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045894(N,N-Dihexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide |...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045879(2-[2-(4-Bromo-phenyl)-1H-indol-3-yl]-N,N-dipropyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045876(N-Hexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | CHE...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045885(N,N-Dipropyl-2-(2-thiophen-2-yl-1H-indol-3-yl)-ace...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045857(2-(2-Phenyl-1H-indol-3-yl)-N,N-dipropyl-acetamide ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045877(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045882(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045874(2-[2-(4-Iodo-phenyl)-1H-indol-3-yl]-N,N-dipropyl-a...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045860(N-Decyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | CHE...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045889(2-(5-Chloro-2-thiophen-2-yl-1H-indol-3-yl)-N,N-dip...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045871(2-(7-Fluoro-2-phenyl-1H-indol-3-yl)-N,N-dipropyl-a...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045873(3-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045878(2-(5-Chloro-2-phenyl-1H-indol-3-yl)-N,N-dihexyl-ac...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045895(2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N,N-dipropyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity by measuring its ability to displace [3H]WB-4101 from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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