Compile Data Set for Download or QSAR
Report error Found 1134 Enz. Inhib. hit(s) with Target = 'Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor'
LigandPNGBDBM50027035(3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...)
Affinity DataEC50:  74nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027036((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027032((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027033(Cyclohexyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-p-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027034((4,5-Dihydro-1H-imidazol-2-ylmethyl)-phenyl-p-toly...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027037((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50027031((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...)
Affinity DataEC50:  53nMAssay Description:Agonistic activity against alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50470860(CHEMBL105328)
Affinity DataEC50:  156nMAssay Description:50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50225293(CHEBI:5553 | Guanabenz | WY-8678)
Affinity DataIC50: 1.70nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 3.10nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50226153(CHEMBL545092)
Affinity DataIC50: 3.30nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
LigandPNGBDBM50226942(CHEMBL39286)
Affinity DataIC50: 3.30nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3.60nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50295557(CHEMBL1732 | 7-Methyl-4,6,6a,7,8,9-hexahydro-indol...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 3.90nMAssay Description:The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 4.80nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataIC50: 5nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50225247(CHEMBL44558)
Affinity DataIC50: 7nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50070193(1-((6aR,9R,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50226155(CHEMBL543684)
Affinity DataIC50: 7nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 7.30nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50048608(Indol-1-yl-pyridin-4-yl-amine | CHEMBL154488)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataIC50: 8nMAssay Description:Ability to inhibit 50% specific binding of [3H]prazosin radioligand to alpha-1 adrenergic receptor in rat cerebrocortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 9.10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50225292(HOE-440 | Symcor Base TTS | Tiamenidine)
Affinity DataIC50: 9.10nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50225294(CHEMBL146100)
Affinity DataIC50: 14nMAssay Description:Binding affinity against alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225288(Tramazoline)
Affinity DataIC50: 16nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225290(CHEMBL146419)
Affinity DataIC50: 17nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 17nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50225235(CHEMBL42909)
Affinity DataIC50: 19nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 20nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM30703(SMR000058526 | 2-[(4-tert-butyl-2,6-dimethyl-pheny...)
Affinity DataIC50: 23nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50048589(Indol-1-yl-methyl-pyridin-4-yl-amine | CHEMBL15284...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM86053(B-HT 920 | cid_5374 | CAS_101626-70-4 | NSC_104870...)
Affinity DataIC50: 25nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50225241(CHEMBL42242)
Affinity DataIC50: 29nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM96559(cid_10648 | Tetrahydrozoline hydrochloride | 2-(1,...)
Affinity DataIC50: 30nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataIC50: 33nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 38nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50225248(CHEMBL42309)
Affinity DataIC50: 39nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 40nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017543(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50: 41nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2018
Entry Details Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2018
Entry Details Article
PubMed
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]-RX 821002 from rat alpha2 adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
LigandPNGBDBM50226156(CHEMBL544627)
Affinity DataIC50: 49nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
LigandPNGBDBM50225250(CHEMBL42237)
Affinity DataIC50: 51nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50225251(CHEMBL295359)
Affinity DataIC50: 53nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
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