Compile Data Set for Download or QSAR
Found 303 Enz. Inhib. hit(s) with Target = 'Arginase-2, mitochondrial'
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  8.5nMAssay Description:Binding affinity to human arginase 2More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  8.5nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H29BN2O4/c19-17(16(21)22,10-4-5-12-18(23)24)11-6-13-20-14-9-15-7-2-1-3-8-15/h1-3,7-8,20,23-24H,4-6,9-14,19H2,(H,21,22)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Show SMILES NC(CCCCB(O)O)(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H32BClN2O5/c22-17-6-4-16(5-7-17)20(27)10-14-24(15-11-20)13-3-9-19(23,18(25)26)8-1-2-12-21(28)29/h4-7,27-29H,1-3,8-15,23H2,(H,25,26)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Show SMILES N[C@@H](CSCCB(O)O)C(O)=O
Show InChI InChI=1S/C5H12BNO4S/c7-4(5(8)9)3-12-2-1-6(10)11/h4,10-11H,1-3,7H2,(H,8,9)/t4-/m0/s1
Affinity DataKi:  30nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O
Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
Affinity DataKi:  51nMAssay Description:Inhibition of arginase 2 (unknown origin)More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O
Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
Affinity DataKi:  51nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O
Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50462601(CHEMBL4250607)
Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C9H10FN3O2/c10-7(8(14)15)5-1-3-6(4-2-5)13-9(11)12/h1-4,7H,(H,14,15)(H4,11,12,13)
Affinity DataKi:  3.22E+5nMAssay Description:Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50462600(CHEMBL4238387)
Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1
Show InChI InChI=1S/C11H13N3O4/c1-6(15)18-9(10(16)17)7-2-4-8(5-3-7)14-11(12)13/h2-5,9H,1H3,(H,16,17)(H4,12,13,14)
Affinity DataKi:  4.37E+5nMAssay Description:Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Show SMILES NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H23BN4O6S/c12-4-5-14-22(20,21)15-6-8(2-1-3-11(18)19)10(13,7-15)9(16)17/h8,14,18-19H,1-7,12-13H2,(H,16,17)/t8-,10-/m0/s1
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547931(CHEMBL4745275)
Show SMILES N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C10H21BN2O4/c12-8-3-6-13-10(7-8,9(14)15)4-1-2-5-11(16)17/h8,13,16-17H,1-7,12H2,(H,14,15)/t8-,10+/m0/s1
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM568474(US11420984, Example 24)
Show SMILES CN[C@H]1CN[C@@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C10H20BN2O4/c1-12-8-6-10(9(14)15,13-7-8)4-2-3-5-11(16)17/h8,12,16-17H,2-7H2,1H3,(H,14,15)/t8-,10+/m1/s1
Affinity DataIC50: 10nMAssay Description:The inhibitory effects of Examples 1 to 30 on the activity of Human Arginase 1 and Arginase 2 activity were quantified by measuring the formation of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561039(CHEMBL4749355 | US11420984, Example 23)
Show SMILES CN[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C10H21BN2O4/c1-12-8-6-10(9(14)15,13-7-8)4-2-3-5-11(16)17/h8,12-13,16-17H,2-7H2,1H3,(H,14,15)/t8-,10-/m1/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of human Arg2 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547934(CHEMBL4757930)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C16H32BN3O5/c1-11(2)9-13(18)14(21)20-12-5-8-19-16(10-12,15(22)23)6-3-4-7-17(24)25/h11-13,19,24-25H,3-10,18H2,1-2H3,(H,20,21)(H,22,23)/t12-,13-,16+/m0/s1
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561038(CHEMBL4752307 | US11420984, Example 7)
Show SMILES N[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c11-7-5-9(8(13)14,12-6-7)3-1-2-4-10(15)16/h7,12,15-16H,1-6,11H2,(H,13,14)/t7-,9-/m1/s1
Affinity DataIC50: 20nMAssay Description:The inhibitory effects of Examples 1 to 30 on the activity of Human Arginase 1 and Arginase 2 activity were quantified by measuring the formation of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561038(CHEMBL4752307 | US11420984, Example 7)
Show SMILES N[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c11-7-5-9(8(13)14,12-6-7)3-1-2-4-10(15)16/h7,12,15-16H,1-6,11H2,(H,13,14)/t7-,9-/m1/s1
Affinity DataIC50: 20nMAssay Description:Inhibition of human Arg2 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547933(CHEMBL4752391)
Show SMILES CC[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-2-11(16)12(19)18-10-5-8-17-14(9-10,13(20)21)6-3-4-7-15(22)23/h10-11,17,22-23H,2-9,16H2,1H3,(H,18,19)(H,20,21)/t10-,11-,14+/m0/s1
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547935(CHEMBL4753285)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C16H32BN3O5/c1-3-11(2)13(18)14(21)20-12-6-9-19-16(10-12,15(22)23)7-4-5-8-17(24)25/h11-13,19,24-25H,3-10,18H2,1-2H3,(H,20,21)(H,22,23)/t11-,12-,13-,16+/m0/s1
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H29BCl2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
Affinity DataIC50: 23nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547936(CHEMBL4750174)
Show SMILES CC(C)(C)[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C16H32BN3O5/c1-15(2,3)12(18)13(21)20-11-6-9-19-16(10-11,14(22)23)7-4-5-8-17(24)25/h11-12,19,24-25H,4-10,18H2,1-3H3,(H,20,21)(H,22,23)/t11-,12+,16+/m0/s1
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50547932(CHEMBL4778086)
Show SMILES CC(C)[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C15H30BN3O5/c1-10(2)12(17)13(20)19-11-5-8-18-15(9-11,14(21)22)6-3-4-7-16(23)24/h10-12,18,23-24H,3-9,17H2,1-2H3,(H,19,20)(H,21,22)/t11-,12-,15+/m0/s1
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H30BClN2O4/c22-16-5-3-14(4-6-16)13-24-17-7-8-18(24)12-15(11-17)20(23,19(25)26)9-1-2-10-21(27)28/h3-6,15,17-18,27-28H,1-2,7-13,23H2,(H,25,26)
Affinity DataIC50: 30nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H29BF2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
Affinity DataIC50: 33nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439244(CHEMBL2418829)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31BN2O4/c22-20(19(24)25,10-4-5-11-21(26)27)16-12-17-8-9-18(13-16)23(17)14-15-6-2-1-3-7-15/h1-3,6-7,16-18,26-27H,4-5,8-14,22H2,(H,24,25)
Affinity DataIC50: 47nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439243(CHEMBL2418998)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C20H31BCl2N2O4/c22-17-6-5-15(18(23)14-17)4-3-11-25-12-7-16(8-13-25)20(24,19(26)27)9-1-2-10-21(28)29/h5-6,14,16,28-29H,1-4,7-13,24H2,(H,26,27)
Affinity DataIC50: 50nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Show SMILES CN[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C14H29BN2O4/c1-16-14(13(18)19,7-3-4-9-15(20)21)8-12-17-10-5-2-6-11-17/h16,20-21H,2-12H2,1H3,(H,18,19)/t14-/m1/s1
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439241(CHEMBL2418999)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(cc2)C(F)(F)F)CC1)C(O)=O
Show InChI InChI=1S/C21H32BF3N2O4/c23-21(24,25)18-7-5-16(6-8-18)4-3-13-27-14-9-17(10-15-27)20(26,19(28)29)11-1-2-12-22(30)31/h5-8,17,30-31H,1-4,9-15,26H2,(H,28,29)
Affinity DataIC50: 70nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50439242(CHEMBL2418828)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2)C(O)=O
Show InChI InChI=1S/C13H25BN2O4/c15-13(12(17)18,5-1-2-6-14(19)20)9-7-10-3-4-11(8-9)16-10/h9-11,16,19-20H,1-8,15H2,(H,17,18)
Affinity DataIC50: 85nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561049(CHEMBL4793482)
Show SMILES N[C@@]1(C[C@H](CCB(O)O)CC[C@H]1CN1CCCCC1)C(O)=O
Show InChI InChI=1S/C15H29BN2O4/c17-15(14(19)20)10-12(6-7-16(21)22)4-5-13(15)11-18-8-2-1-3-9-18/h12-13,21-22H,1-11,17H2,(H,19,20)/t12-,13-,15+/m0/s1
Affinity DataIC50: 100nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290378((3R,4S)-3-amino-1-(2-aminocyclopentyl)-4-(3- boron...)
Show SMILES NC1CCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-10-4-1-5-11(10)17-7-9(3-2-6-14(20)21)13(16,8-17)12(18)19/h9-11,20-21H,1-8,15-16H2,(H,18,19)/t9-,10?,11?,13-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290380((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(4- carbox...)
Show SMILES N[C@]1(CN(CCCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H27BN2O4/c19-17(16(21)22)13-20(12-15(17)9-4-10-18(23)24)11-5-8-14-6-2-1-3-7-14/h1-3,6-7,15,23-24H,4-5,8-13,19H2,(H,21,22)/t15-,17-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290385((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-2-...)
Show SMILES N[C@]1(CN(CC2CCCCN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(9-12-5-1-2-7-17-12)8-11(14)4-3-6-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t11-,12?,14-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290388((3R,4S)-3-amino-1-(2-aminoethyl)-4-(3-boronopropyl...)
Show SMILES NCCN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H22BN3O4/c12-4-5-14-6-8(2-1-3-11(17)18)10(13,7-14)9(15)16/h8,17-18H,1-7,12-13H2,(H,15,16)/t8-,10-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290391((3R,4S)-3-amino-4-(3-boronopropyl)-1,3'-bipyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCNC1)C(O)=O
Show InChI InChI=1S/C12H24BN3O4/c14-12(11(17)18)8-16(10-3-5-15-6-10)7-9(12)2-1-4-13(19)20/h9-10,15,19-20H,1-8,14H2,(H,17,18)/t9-,10?,12-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290402((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(pyrrolidi...)
Show SMILES N[C@]1(CN(CCN2CCCC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)11-18(9-8-17-6-1-2-7-17)10-12(14)4-3-5-15(21)22/h12,21-22H,1-11,16H2,(H,19,20)/t12-,14-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290403((3R,4S)-3-amino-4-(3-boronopropyl)-1-(((S)-1,2,3,4...)
Show SMILES N[C@]1(CN(C[C@@H]2Cc3ccccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H28BN3O4/c20-18(17(23)24)12-22(10-15(18)6-3-7-19(25)26)11-16-8-13-4-1-2-5-14(13)9-21-16/h1-2,4-5,15-16,21,25-26H,3,6-12,20H2,(H,23,24)/t15-,16-,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290404((3R,4S)-3-amino-1-(2-(benzylamino)ethyl)-4-(3- bor...)
Show SMILES N[C@]1(CN(CCNCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H28BN3O4/c19-17(16(22)23)13-21(12-15(17)7-4-8-18(24)25)10-9-20-11-14-5-2-1-3-6-14/h1-3,5-6,15,20,24-25H,4,7-13,19H2,(H,22,23)/t15-,17-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290405((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(3,4- dich...)
Show SMILES N[C@]1(CN(CCNCc2ccc(Cl)c(Cl)c2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H26BCl2N3O4/c19-14-4-3-12(8-15(14)20)9-22-6-7-23-10-13(2-1-5-18(26)27)17(21,11-23)16(24)25/h3-4,8,13,22,26-27H,1-2,5-7,9-11,21H2,(H,24,25)/t13-,17-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290408((3R,4S)-3-amino-1-(2-aminocyclohexyl)-4-(3- borono...)
Show SMILES NC1CCCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-11-5-1-2-6-12(11)18-8-10(4-3-7-15(21)22)14(17,9-18)13(19)20/h10-12,21-22H,1-9,16-17H2,(H,19,20)/t10-,11?,12?,14-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290413((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H27BClN3O4/c20-15-4-3-12-7-16(22-8-13(12)6-15)10-23-9-14(2-1-5-19(26)27)18(21,11-23)17(24)25/h3-4,6,14,16,22,26-27H,1-2,5,7-11,21H2,(H,24,25)/t14-,16?,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290415((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3cc(Cl)ccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H27BClN3O4/c20-15-4-3-12-8-22-16(7-13(12)6-15)10-23-9-14(2-1-5-19(26)27)18(21,11-23)17(24)25/h3-4,6,14,16,22,26-27H,1-2,5,7-11,21H2,(H,24,25)/t14-,16?,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290416((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...)
Show SMILES N[C@]1(CN(CCNc2ccc(cc2)-c2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C22H30BN3O4/c24-22(21(27)28)16-26(15-19(22)7-4-12-23(29)30)14-13-25-20-10-8-18(9-11-20)17-5-2-1-3-6-17/h1-3,5-6,8-11,19,25,29-30H,4,7,12-16,24H2,(H,27,28)/t19-,22-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290419((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-(trifluor...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(cc3CN2)C(F)(F)F)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C19H27BF3N3O4/c21-19(22,23)14-4-3-12-7-16(25-8-13(12)6-14)10-26-9-15(2-1-5-20(29)30)18(24,11-26)17(27)28/h3-4,6,15-16,25,29-30H,1-2,5,7-11,24H2,(H,27,28)/t15-,16?,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290420((3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O
Show InChI InChI=1S/C18H25BClN3O5/c20-14-4-3-11-7-15(22-8-12(11)6-14)16(24)23-9-13(2-1-5-19(27)28)18(21,10-23)17(25)26/h3-4,6,13,15,22,27-28H,1-2,5,7-10,21H2,(H,25,26)/t13-,15?,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290421((3R,4S)-3-amino-1-(2-amino-3-phenylpropyl)-4-(3- b...)
Show SMILES NC(CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C17H28BN3O4/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23)/t14-,15?,17-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290423((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...)
Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290426((1S,2S,4S)-1-amino-4-(benzylamino)-2-(3- boronopro...)
Show SMILES N[C@]1(C[C@H](C[C@@H]1CCCB(O)O)NCc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H25BN2O4/c18-16(15(20)21)10-14(9-13(16)7-4-8-17(22)23)19-11-12-5-2-1-3-6-12/h1-3,5-6,13-14,19,22-23H,4,7-11,18H2,(H,20,21)/t13-,14-,16-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290427((1S,2S,4S)-1-amino-2-(3-boronopropyl)-4- (dimethyl...)
Show SMILES CN(C)[C@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C11H23BN2O4/c1-14(2)9-6-8(4-3-5-12(17)18)11(13,7-9)10(15)16/h8-9,17-18H,3-7,13H2,1-2H3,(H,15,16)/t8-,9-,11-/m0/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM290428((1S,2S,4R)-1-amino-4-(aminomethyl)-2-(3- boronopro...)
Show SMILES NC[C@@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H21BN2O4/c12-6-7-4-8(2-1-3-11(16)17)10(13,5-7)9(14)15/h7-8,16-17H,1-6,12-13H2,(H,14,15)/t7-,8+,10+/m1/s1
Affinity DataIC50: 125nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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