Compile Data Set for Download or QSAR
Report error Found 1958 Enz. Inhib. hit(s) with Target = 'C-X-C chemokine receptor type 4'
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50555514(CHEMBL4751485)
Affinity DataIC50: 0.0200nMAssay Description:Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced calcium signal incubated for 20 mins by FLIPR ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50565499(CHEMBL4799439)
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced cytosolic calcium flux preincubated for 20 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50225415(WZ-811 | N,N'-di-2-pyridinyl-1,4-benzenedimethanam...)
Affinity DataEC50:  0.300nMAssay Description:Displacement of biotinylated TN14003 from CXCR4 in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50225415(WZ-811 | N,N'-di-2-pyridinyl-1,4-benzenedimethanam...)
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of CXCR4-mediated chemotaxis in SDF1-stimulated human U937 cells treated 15 mins before SDF1 challenge measured after 2 hrs by luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50102036(Derivative of T140 peptide | CHEMBL2372985)
Affinity DataEC50:  0.400nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50565506(CHEMBL4792975)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced cytosolic calcium flux preincubated for 20 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50102035(Derivative of T140 peptide | CHEMBL2372997)
Affinity DataEC50:  0.5nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50225416(TN-14003 | CHEMBL393882)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CXCR4 in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50102037(Derivative of T140 peptide | CHEMBL2372993)
Affinity DataEC50:  0.600nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50335557(N,N-dipropyl-N'-[4-({[(1H-imidazol-2-yl)methyl][(1...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 (unknown origin) expressed in CHO cells by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50335557(N,N-dipropyl-N'-[4-({[(1H-imidazol-2-yl)methyl][(1...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]SDF-1alpha form CXCR4 expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50335557(N,N-dipropyl-N'-[4-({[(1H-imidazol-2-yl)methyl][(1...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity to CXCR4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50458238(CHEMBL4203703)
Affinity DataIC50: 0.730nMAssay Description:Antagonist activity at CXCR4 in human CD4+ T cells assessed as inhibition of CXCL12-mediated cytosolic calcium level preincubated with compounds foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50347490(CHEMBL1802333)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM694486(CPCR4.3 | US20240293587, Compound R)
Affinity DataIC50: 0.800nMAssay Description:For IC50 determination using Jurkat or Eμ-Myc1080 cells, samples containing 2×105 cells (or 4×105 cells; exact cell number used in the respectiv...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Mouse)
Technische University Munchen

US Patent
LigandPNGBDBM694486(CPCR4.3 | US20240293587, Compound R)
Affinity DataIC50: 0.800nMAssay Description:For IC50 determination using Jurkat or Eμ-Myc1080 cells, samples containing 2×105 cells (or 4×105 cells; exact cell number used in the respectiv...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50035696(AMD-3100 | CHEMBL18442 | 11-{4-[4,8, 11-1,4,8,11te...)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50035696(AMD-3100 | CHEMBL18442 | 11-{4-[4,8, 11-1,4,8,11te...)
Affinity DataIC50: 0.810nMAssay Description:Displacement of [125I]SDF1alpha from CXCR4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50: 0.870nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated 30 mins before agonist challenge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194584(US9205085, MSX-207)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194573(US9205085, MSX- 207)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194583(US9205085, MSX- 222)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50369468(CHEMBL1202231)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM221760(US9314468, Table 7, Compound 47)
Affinity DataIC50: 1nMT: 2°CAssay Description:Functional modulation of CXCR4 was determined by calcium mobilization assay using leukemic lymphoid CEM cells, which naturally express high levels of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50443545(CHEMBL3091683)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194582(US9205085, MSX- 221)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50277349(CHEMBL4163246)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194561(US9205085, MSX- 192)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM221860(US9314468, Table 7, Compound 147)
Affinity DataIC50: 1nMT: 2°CAssay Description:Functional modulation of CXCR4 was determined by calcium mobilization assay using leukemic lymphoid CEM cells, which naturally express high levels of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194521(US9205085, MSX- 205)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194568(US9205085, MSX- 201)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194570(US9205085, MSX- 203)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194569(US9205085, MSX- 202)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194563(US9205085, MSX- 194)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194562(US9205085, MSX- 193)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Rat)
Emory University

US Patent
LigandPNGBDBM194565(US9205085, MSX- 197)
Affinity DataIC50: 1nMAssay Description:A synthetic 14-mer peptide, TN14003, was previously reported to block both SDF-1/CXCR4 mediated invasion in vitro and metastasis in vivo with a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50326057(([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7...)
Affinity DataIC50: 1.07nMAssay Description:Antagonist activity at human CXCR4 expressed in HEK293 cells assessed as inhibition of SDF1-induced response treated before agonist challenge measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50247128((6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazo...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50565504(CHEMBL4799191)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced cytosolic calcium flux preincubated for 20 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50247128((6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazo...)
Affinity DataIC50: 1.10nMAssay Description:Activity at CXCR4 in human CEM cells assessed as inhibition of CXCL12-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50102047(Derivative of T140 peptide | CHEMBL2373004)
Affinity DataEC50:  1.20nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50333890(N-((1H-benzo[d]imidazol-2-yl)methyl)-N-((4-(aminom...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells expressing CD4 assessed as inhibition of SDF-1-induced Ca2+ signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50379090(CHEMBL2012527)
Affinity DataIC50: 1.36nMAssay Description:Displacement of [125I]-SDF-1alpha from human CXCR4 receptor expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50250705(CHEMBL4078698)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]-CXCL12 from CXCR4 in human CCRF-CEM cells after 1 hr by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50379088(CHEMBL2012525)
Affinity DataIC50: 1.56nMAssay Description:Displacement of [125I]-SDF-1alpha from human CXCR4 receptor expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Mouse)
Technische University Munchen

US Patent
LigandPNGBDBM694503(c(y-(NHex-Gua-Ac)a-R-Nal-G) | US20240293587, Compo...)
Affinity DataIC50: 1.60nMAssay Description:For IC50 determination using Jurkat or Eμ-Myc1080 cells, samples containing 2×105 cells (or 4×105 cells; exact cell number used in the respectiv...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50517802(CHEMBL4457992)
Affinity DataIC50: 1.60nMAssay Description:Competitive inhibition of TAMRAAc-TZ14011 binding to CXCR4 (unknown origin) expressed in CHO cells in presence of ZnCl2 by NanoBRET assay relative to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50603567(CHEMBL5172755)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at CXCR4 receptor in SDF-1alpha-stimulated human SUP-T1 cells measured by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM694498(c(y-(NHex-Gua-Prop-Ac)a-R-Nal-G) | US20240293587, ...)
Affinity DataIC50: 1.70nMAssay Description:For IC50 determination using Jurkat or Eμ-Myc1080 cells, samples containing 2×105 cells (or 4×105 cells; exact cell number used in the respectiv...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

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