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Report error Found 15275 Enz. Inhib. hit(s) with Target = 'Cannabinoid receptor 1'
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50176988(8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-he...)
Affinity DataKi:  0.000350nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176988(8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-he...)
Affinity DataKi:  0.000350nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176980(8-chloro-1-(2',4'-dichlorophenyl)-N-homopiperidin-...)
Affinity DataKi:  0.00100nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176989(8-chloro-1-(2',4'-dichlorophenyl)-N-pyrrolidin-1-y...)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176979(8-methyl-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl...)
Affinity DataKi:  0.00520nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176986(8-bromo-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-...)
Affinity DataKi:  0.00800nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243536(CHEMBL4062749)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243536(CHEMBL4062749)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176990(8-chloro-1-(2',4'-dichlorophenyl)-N-p-methoxylphen...)
Affinity DataKi:  0.0130nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388901(CHEMBL2063237)
Affinity DataKi:  0.0300nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388885(CHEMBL2063238)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rat)
Hebrew University

Curated by ChEMBL
LigandPNGBDBM50229577(CHEMBL63818)
Affinity DataKi:  0.0450nMAssay Description:Compound was evaluated for the competitive inhibition of [3H]3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388902(CHEMBL2063239)
Affinity DataKi:  0.0500nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50067499((6aR,10aR)-3(1,1-dimethylheptyl)-9-hydroxymethyl)-...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388887(CHEMBL2063240)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388896(CHEMBL2063249)
Affinity DataKi:  0.0800nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388893(CHEMBL2063246)
Affinity DataKi:  0.0800nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388887(CHEMBL2063240)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]SR141716A form human CB1 receptor expressed in HEK293 cells after 60 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50176411(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  0.100nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50516776(CHEMBL4437741)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1R expressed in HEK293 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50061108(3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimeth...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity was determined for Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50061108(3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimeth...)
Affinity DataKi:  0.100nMAssay Description:Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50000727((R)-3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-di...)
Affinity DataKi:  0.100nMAssay Description:Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50301739(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human CB1 receptor transfected in CHO-K1cells by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50301747(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-3-(...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human CB1 receptor transfected in CHO-K1cells by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243589(CHEMBL4095223)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243608(CHEMBL4100882)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243625(CHEMBL4094098)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243545(CHEMBL4078689)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243589(CHEMBL4095223)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243608(CHEMBL4100882)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243625(CHEMBL4094098)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243545(CHEMBL4078689)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50532778(CHEMBL4465566 | US10882838, Example 3.6)
Affinity DataKi:  0.100nMAssay Description:All the cannabinoids discussed in this invention are tested for their ability to bind to CB1 and CB2 receptors using membranes from rat brain or HEK2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50532778(CHEMBL4465566 | US10882838, Example 3.6)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50532778(CHEMBL4465566 | US10882838, Example 3.6)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50176407(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...)
Affinity DataKi:  0.100nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50176987(8-methyl-1-(2',4'-dichlorophenyl)-N-pyrrolidin-1-y...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50067497((2S,4S,4aS,6R,8aR)-4-[4-(1,1-Dimethyl-heptyl)-2-hy...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]CP-55,940 binding to Cannabinoid receptor 1 in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50516789(CHEMBL4559193)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1R expressed in HEK293 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388900(CHEMBL2063235)
Affinity DataKi:  0.110nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388892(CHEMBL2063245)
Affinity DataKi:  0.110nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rat)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50067497((2S,4S,4aS,6R,8aR)-4-[4-(1,1-Dimethyl-heptyl)-2-hy...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388892(CHEMBL2063245)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]SR141716A form human CB1 receptor expressed in HEK293 cells after 60 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50347380(CHEMBL1801350)
Affinity DataKi:  0.120nMAssay Description:Displacement of radioligand from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50388891(CHEMBL2063244)
Affinity DataKi:  0.120nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243626(CHEMBL4089821)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243588(CHEMBL4067800)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243645(CHEMBL4087520)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50243627(CHEMBL4068708)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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