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Report error Found 1074 Enz. Inhib. hit(s) with Target = 'Chymase'
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataKon:  2.10E-8M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 12.5 to 200 nM by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataKon:  1.25E-7M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 6 to 1000 nM by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100340(US8501749, 40)
Affinity DataIC50: 0.300nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100336(US8501749, 36)
Affinity DataIC50: 0.400nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50332961((3S,4S)-3-Benzyl-4-(4-methylpiperazincarbonyl)phen...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100335(US8501749, 35)
Affinity DataIC50: 0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100338(US8501749, 38)
Affinity DataIC50: 0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50101136(1,3-Bis-benzo[1,3]dioxol-5-ylmethyl-[1,3]diazetidi...)
Affinity DataIC50: 0.850nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100324(US8501749, 24)
Affinity DataIC50: 0.900nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255962(US9481672, 140)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255964(US9481672, 142)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255968(US9481672, 146)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256036(US9481672, 217)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256064(US9481672, 246)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256065(US9481672, 247)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256099(US9481672, 281)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100341(US8501749, 41)
Affinity DataIC50: 1.30nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100330(US8501749, 30)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100339(US8501749, 39)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM88376(US9695131, 13)
Affinity DataIC50: 1.80nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255961(US9481672, 139)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255963(US9481672, 141)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255965(US9481672, 143)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255966(US9481672, 144)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255967(US9481672, 145)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255969(US9481672, 147)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255971(US9481672, 149)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255973(US9481672, 151)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256043(US9481672, 224)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256046(US9481672, 227)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256059(US9481672, 241)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256062(US9481672, 244)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256066(US9481672, 248)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256083(US9481672, 265)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256088(BDBM256092 | BDBM256093 | US9481672, 270)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256095(US9481672, 277)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256111(US9481672, 294)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM256116(US9481672, 300)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255927(US9481672, 104)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255944(US9481672, 122)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255954(US9481672, 132)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255956(US9481672, 134)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM255958(US9481672, 136)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50101135(1,3-Bis-(4-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100320(US8501749, 20)
Affinity DataIC50: 2.10nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100331(US8501749, 31)
Affinity DataIC50: 2.20nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50101137(1,3-Bis-(3-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50: 2.30nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100325(US8501749, 25)
Affinity DataIC50: 2.5nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100318(US8501749, 18)
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100334(US8501749, 34)
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails
US Patent

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