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Report error Found 998 Enz. Inhib. hit(s) with Target = 'Cysteine protease'
TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM161376(US9108950, 1 | US9724347, Example 1 | US10238658, ...)
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent

TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM50614152(CHEMBL4552904)
Affinity DataKd:  1.43E+4nMAssay Description:Binding affinity to N-terminal His6/SUMO-tagged full length human ATG4B expressed in Escherichia coli BL21 (DE3) cells by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50226103((2S,3R)-ethyl 3-((S)-2-((S)-2-(benzyloxycarbonyl)-...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM12042(L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatin...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 5nMAssay Description:Inhibition of rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311247((S)-4-methyl-N-(5-phenyl-1-(phenylsulfonyl)pent-1-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311248((S)-3-phenyl-N-(5-phenyl-1-(phenylsulfonyl)pent-1-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311250((S)-N-(5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Leishmania donovani)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Leishmania donovani cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM50536857(CHEMBL4581663)
Affinity DataIC50: 15nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50611827(CHEMBL5275445)
Affinity DataIC50: 16nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463157(CHEMBL4244656)
Affinity DataIC50: 20nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCysteine protease falcipain-3 [5-492](malaria parasite P. falciparum)
University of Algarve

Curated by ChEMBL
LigandPNGBDBM50243232(N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-P...)
Affinity DataIC50: 21nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463153(CHEMBL4247075)
Affinity DataIC50: 26nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50268555(6-(3-(furan-3-yl)benzylamino)-9-(3-hydroxypropyl)-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311246((S)-4-methyl-N-(5-phenyl-1-(phenylsulfonyl)pent-1-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50226104((2R,3S)-ethyl 3-((S)-2-((S)-2-(benzyloxycarbonyl)-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463142(CHEMBL4238441)
Affinity DataIC50: 30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463154(CHEMBL4251480)
Affinity DataIC50: 30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463154(CHEMBL4251480)
Affinity DataIC50: 31nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCysteine protease falcipain-3 [5-492](malaria parasite P. falciparum)
University of Algarve

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 35nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157207((1E,2E)-1-(3,4-dichlorophenyl)-3-phenylprop-2-en-1...)
Affinity DataIC50: 38nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157211((E)-(3,4-dichlorophenyl)(4-methylphenyl)methanone ...)
Affinity DataIC50: 38nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50114651((1E)-1-(3-bromophenyl)ethan-1-one thiosemicarbazon...)
Affinity DataIC50: 50nMAssay Description:Inhibition of rhodesain from Trypanosoma brucei rhodesienseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311249((S)-N-(5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311251((S)-N-(5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM50536857(CHEMBL4581663)
Affinity DataIC50: 57nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157204((E)-2-(1-(3,4-dichlorophenyl)pentylidene)hydrazine...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157210((E)-(3,4-dichlorophenyl)(2-phenylcyclopropyl)metha...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 60nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157206((1Z)-1-(3,4-dichlorophenyl)-2-phenoxyethan-1-one t...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536838(CHEMBL4520267)
Affinity DataIC50: 73nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease falcipain-3 [5-492](malaria parasite P. falciparum)
University of Algarve

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 75nMAssay Description:Inhibition of falcipain3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157205((1E)-1-(3,4-dichlorophenyl)-2-phenylethan-1-one th...)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536838(CHEMBL4520267)
Affinity DataIC50: 80nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50148049((1E)-1-(1,1'-biphenyl-4-yl)ethan-1-one thiosemicar...)
Affinity DataIC50: 90nMAssay Description:Inhibition of rhodesain from Trypanosoma brucei rhodesienseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50157209((1E)-1-(3,4-dichlorophenyl)-3-phenylpropan-1-one t...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense recombinant rhodesain by fluorescence techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50311252((1R,2R)-2-(4-chlorobenzoyl)-N-((S)-5-phenyl-1-(phe...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
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US Patent
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 100nMAssay Description:Inhibition of ATG4B (unknown origin) using FRETGATE-16 as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536857(CHEMBL4581663)
Affinity DataIC50: 100nMAssay Description:Inhibition of ATG4B (unknown origin) using FRETGATE-16 as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50114608((1E)-1-(3,4-dichlorophenyl)propan-1-one thiosemica...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against rhodesain of Trypanosoma brucei rhodesienceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463147(CHEMBL4237990)
Affinity DataIC50: 110nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 110nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Respivert

US Patent
LigandPNGBDBM50536856(CHEMBL4520585)
Affinity DataIC50: 130nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463151(CHEMBL4249696)
Affinity DataIC50: 140nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50463143(CHEMBL4245127)
Affinity DataIC50: 145nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
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