Compile Data Set for Download or QSAR
Report error Found 291 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 26A1'
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91698(Oxazolamine derivative, 5a)
Affinity DataEC50:  3.50E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91699(Oxazolamine derivative, 5b)
Affinity DataEC50:  9.00E+3nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91700(Oxazolamine derivative, 5c)
Affinity DataEC50:  2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91701(Oxazolamine derivative, 5d)
Affinity DataEC50:  5.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91702(Oxazolamine derivative, 5e)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91703(Oxazolamine derivative, 5f)
Affinity DataEC50:  1.20E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50176808(6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-be...)
Affinity DataEC50:  7.00E+3nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50253810(R115866 | CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4...)
Affinity DataEC50:  5nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91704(1H-1,2,4-triazole, 11)
Affinity DataEC50:  1.80E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91705(1H-1,2,4-triazole, 12)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM91706(1H-tetrazole, 13)
Affinity DataEC50: >2.00E+4nMAssay Description:The imidazole derivatives were evaluated for their retinoic acid metabolism inhibitory activity using a MCF-7 cell assay, using radiolabelled all-tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50353582(CHEMBL1831083)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183224(3-[6-(2-dimethylamino-1-imidazol-1-yl-butyl)-napht...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183243(1-((6-((1R,2R)-2-(diethylamino)-1-(1H-imidazol-1-y...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183229(1-((6-((1R,2R)-1-(1H-imidazol-1-yl)-2-(isopropyl(m...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183237(3-(6-((1R,2R)-1-(1H-imidazol-1-yl)-2-(isopropyl(me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342130(3-[4-(6-Hydroxy-naphthalen-2-ylamino)-phenyl]-3-im...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162787(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162787(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 3.30nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162776(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162776(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 3.5nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50377963(R-115866 | CHEMBL224305)
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP26A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183231(1-((6-((1R,2R)-2-(ethyl(methyl)amino)-1-(1H-imidaz...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM393281(US9963439, R116010)
Affinity DataIC50: 4.30nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183225(3-(6-((1R,2R)-2-(diethylamino)-1-(1H-imidazol-1-yl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50377963(R-115866 | CHEMBL224305)
Affinity DataIC50: 5nMAssay Description:Inhibition of CYP26A1 in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50253810(R115866 | CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50253810(R115866 | CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4...)
Affinity DataIC50: 5.10nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50391726(CHEMBL2146987)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162791(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162791(4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 6nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342143(3-Imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-1-yl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50391728(CHEMBL2147090)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162788(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162788(3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naph...)
Affinity DataIC50: 7nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183228(1-((6-((1R,2R)-2-(dimethylamino)-1-(1H-imidazol-1-...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50162782({4-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-nap...)
Affinity DataIC50: 8nMAssay Description:Potency towards cytochrome P 450 26 enzyme activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342129(3-Imidazol-1-yl-3-[4-(6-methoxy-naphthalen-2-ylami...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342141(3-[4-(Benzo[1,3]dioxol-5-ylamino)-phenyl]-3-imidaz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50342141(3-[4-(Benzo[1,3]dioxol-5-ylamino)-phenyl]-3-imidaz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

LigandPNGBDBM50183241(3-(6-((1R,2R)-2-(ethyl(methyl)amino)-1-(1H-imidazo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP26 expressed in human T47D cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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