Compile Data Set for Download or QSAR
Report error Found 6758 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2D6'
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50275432(S-2-(6-(1,4-dihydrobenzo[d][1,2]dioxine-6-sulfonam...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50275377(S-2-(6-(4-(3-(dimethylamino)propoxy)phenylsulfonam...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348732(CHEMBL1801504)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348733(CHEMBL1801060)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50348709(CHEMBL1801062)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50448495(CHEMBL3126836)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50448496(CHEMBL3126835)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50448497(CHEMBL3126834)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50448494(CHEMBL3126657)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50246760(CHEMBL4075348)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50538668(CHEMBL4634455 | US11518761, Example 159)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50538669(CHEMBL4646408)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50538670(CHEMBL4642579)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50566257(CHEMBL4785210)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50114568(CHEMBL3608913)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 by luminometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50114574(CHEMBL3608921)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 by luminometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50114573(CHEMBL3608920)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 by luminometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50114572(CHEMBL3608916)
Affinity DataEC50:  4.12E+4nMAssay Description:Inhibition of human CYP2D6 by luminometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50114571(CHEMBL3608915)
Affinity DataEC50:  4.94E+3nMAssay Description:Inhibition of human CYP2D6 by luminometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 0.0450nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50175387(2-[((2R)-3-{[1,1-Dimethyl-2-(2-naphthalenyl)ethyl]...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50268077((S)-4-(2-hydroxy-3-(1-(4-methoxyphenyl)-2-methylpr...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of CYP2D6 (unknown origin) using EOMCC as a substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant microsomal CYP2D6 using {3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin} as substrate assessed as ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50314267((+)-(S)-N,N-dimethyl-2-(3-(1-(pyridin-3-yl)ethyl)b...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant CYP2D6 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50297374(3-(3-(tert-butylthio)-5-(pyridin-2-ylmethoxy)-1-(4...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50378146(CHEMBL1204009)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM493606(US10988445, Example 202)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50297370(3-(3-(tert-butylthio)-5-(pyridin-2-ylmethoxy)-1-(4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM247367(US9447092, Comparator 1, Example 56)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CYP2D6 in human liver microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant CYP2D6 using luciferin as substrate preincubated for 10 mins followed by substrate addition and measured after 50 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CYP2D6 (unknown origin) expressed in insect cell microsomes using dibenzylfluorescein substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50413014(CHEMBL497171)
Affinity DataIC50: 7.94nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50334783(trans-(1S,2S)-1-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 8.40nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50: 9nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50: 9nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 9.67nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50314262((-)-(R)-N-methyl-2-(3-(1-(pyridin-2-yl)ethyl)benzo...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of recombinant CYP2D6 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50210012((3R,4R)-methyl 3-(((S)-3-(4-fluorobenzyl)piperidin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50297371(3-(3-(tert-butylthio)-5-(pyridin-2-ylmethoxy)-1-(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50297377(3-[3-tert-Butylsulfanyl-1-[4-(6-methylpyridin-3-yl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50297384(3-(3-(tert-butylthio)-1-(4-(5-methoxypyridin-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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