Compile Data Set for Download or QSAR
Report error Found 3170 Enz. Inhib. hit(s) with Target = 'DNA-dependent protein kinase catalytic subunit'
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439947(CHEMBL2420310)
Affinity DataEC50:  109nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439946(CHEMBL2420287)
Affinity DataEC50:  166nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataEC50:  136nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50439948(CHEMBL2420425)
Affinity DataEC50:  426nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50156495(NU-7441 | NU-7432 | 8-Dibenzothiophen-4-yl-2-morph...)
Affinity DataEC50:  212nMAssay Description:Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50308135(PKI-587 | 1-(4-{[4-(Dimethylamino)piperidin-1-yl]c...)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataEC50:  118nMAssay Description:Inhibition of DNAPK in human HCT116 cells assessed as after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413448(US10407446, Example 1 | 9-((1r,4r)-4-hydroxycycloh...)
Affinity DataIC50: 0.0794nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413448(US10407446, Example 1 | 9-((1r,4r)-4-hydroxycycloh...)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648224(US11884671, Example 1)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648226(US11884671, Example 3)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648229(US11884671, Example 6)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648230(US11884671, Example 7)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648231(US11884671, Example 8)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648232(US11884671, Example 9)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648233(US11884671, Example 13 | US11884671, Example 10)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648235(US11884671, Example 12)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648237(US11884671, Example 14)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648238(US11884671, Example 15)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648239(US11884671, Example 16)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599239(CHEMBL5184141 | US11884671, Example 32)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648257(US11884671, Example 34)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648258(US11884671, Example 35)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648240(US11884671, Example 17)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648243(US11884671, Example 20)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648244(US11884671, Example 21)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648250(US11884671, Example 27)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648251(US11884671, Example 28)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599238(CHEMBL5181303 | US11884671, Example 29)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599238(CHEMBL5181303 | US11884671, Example 29)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599239(CHEMBL5184141 | US11884671, Example 32)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648274(US11884671, Example 51)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599237(CHEMBL5180090 | US11884671, Example 30)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599237(CHEMBL5180090 | US11884671, Example 30)
Affinity DataIC50: 0.126nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599240(CHEMBL5194436 | US11884671, Example 31)
Affinity DataIC50: 0.126nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50599240(CHEMBL5194436 | US11884671, Example 31)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413449(US10407446, Example 2 | 9-((1s,4s)-4-hydroxycycloh...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413454(US10407446, Example 7 | (S)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648225(US11884671, Example 2)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648234(US11884671, Example 11)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648242(US11884671, Example 19)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648245(US11884671, Example 22)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM648249(US11884671, Example 26)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
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