Compile Data Set for Download or QSAR
Report error Found 4295 Enz. Inhib. hit(s) with Target = 'Disintegrin and metalloproteinase domain-containing protein 17'
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419135(US10457678, Compound 7)
Affinity DataEC50:  7.00E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419140(US10457678, Compound 10)
Affinity DataEC50:  1.70E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419141(US10457678, Compound 17)
Affinity DataEC50:  3.00E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419153(US10457678, Compound 26)
Affinity DataEC50:  2.40E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419159(US10457678, Compound 21)
Affinity DataEC50:  5.00E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419173(US10457678, Compound 32)
Affinity DataEC50:  2.50E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419177(US10457678, Compound 33)
Affinity DataEC50:  1.00E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419178(US10457678, Compound 34)
Affinity DataEC50:  2.00E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419182(US10457678, Compound 35)
Affinity DataEC50:  3.50E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM419183(US10457678, Compound 36)
Affinity DataEC50:  1.05E+3nMAssay Description:TNF-α can induce necroptosis in Jurkat cells (human T lymphocytes) when FADD was deleted. This model was used to screen various libraries of che...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50195927(N-(5-methyl-2,4,6-trioxo-hexahydropyrimidin-5-yl)-...)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136286((3R,4S)-1-(Furan-2-carbonyl)-piperidine-3,4-dicarb...)
Affinity DataIC50: 0.0660nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332481((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332481((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50245492(CHEMBL4082554)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant TACE catalytic domain (unknown origin) using pro-TNFalpha peptide Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50070453(BB-1101 | (2R,3S)-2-Allyl-N*1*-hydroxy-3-isobutyl-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50247606(BMS-561392 | (R)-2-((R)-3-amino-3-(4-((2-methylqui...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082973((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.210nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136266((3R,4S)-1-Isobutyryl-piperidine-3,4-dicarboxylic a...)
Affinity DataIC50: 0.220nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082965((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.230nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136270((3R,4S)-1-Butyryl-piperidine-3,4-dicarboxylic acid...)
Affinity DataIC50: 0.260nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332476(2-((6-Methyl-2-oxo-2H-chromen-3-yl)methyl)-5-(3-(2...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332476(2-((6-Methyl-2-oxo-2H-chromen-3-yl)methyl)-5-(3-(2...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136285((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataIC50: 0.280nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332480(4-(4-(2-(Diethylamino)ethoxy)phenyl)-2-((7-methyl-...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136261((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataIC50: 0.300nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136275((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataIC50: 0.300nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136283((3R,4S)-1-(Furan-2-carbonyl)-piperidine-3,4-dicarb...)
Affinity DataIC50: 0.300nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332470(N-Hydroxy-4-(4-hydroxyphenyl)-2-((6-methyl-2-oxo-2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of TACE (unknown origin) using fluorogenic LAQAVRSSSR peptide as a substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136262((3R,4S)-1-(1-Methyl-1H-imidazole-4-sulfonyl)-piper...)
Affinity DataIC50: 0.310nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082946((2R,3S)-2-(7-Bromo-2-methyl-4-oxo-3,4-dihydro-quin...)
Affinity DataIC50: 0.330nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082959((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.330nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50236612(CHEMBL4071465)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082983((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50371344(CHEMBL403401)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50236612(CHEMBL4071465)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TACE (unknown origin) using fluorogenic LAQAVRSSSR peptide as a substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136263((3R,4S)-Piperidine-1,3,4-tricarboxylic acid 1-tert...)
Affinity DataIC50: 0.410nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082974((2S,3S)-2-(3,5-Dichloro-phenylsulfanyl)-N*4*-((S)-...)
Affinity DataIC50: 0.420nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082993((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.430nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50082948((2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: 0.440nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136279((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataIC50: 0.440nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136269((3R,4S)-1-Cyclopropanecarbonyl-piperidine-3,4-dica...)
Affinity DataIC50: 0.450nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50332479(4-(4-(2-(Diethylamino)ethoxy)phenyl)-2-((7-fluoro-...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50168742((2R,3R)-3-Hydroxy-3-methyl-1-[4-(quinolin-8-ylmeth...)
Affinity DataIC50: 0.480nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataIC50: 0.480nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Institut National De La Sante Et De La Recherche Medicale (Inserm)

US Patent
LigandPNGBDBM50224961(2-benzyl-N-hydroxy-3-(6-methyl-2-oxo-2H-chromen-3-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TACE by fluorescent spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
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