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Report error Found 377 Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 2'
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592916(CHEMBL5206486)
Affinity DataEC50:  11nMAssay Description:Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592918(CHEMBL5187206)
Affinity DataEC50:  20nMAssay Description:Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592916(CHEMBL5206486)
Affinity DataEC50:  25nMAssay Description:Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592918(CHEMBL5187206)
Affinity DataEC50:  0.100nMAssay Description:Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595738(CHEMBL1834164)
Affinity DataEC50:  1.83E+3nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50103601(CHEBI:29007 | Ceftriaxone)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595739(CHEMBL5178416)
Affinity DataEC50:  0.260nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595740(CHEMBL5202745)
Affinity DataEC50:  0.800nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595741(CHEMBL5208038)
Affinity DataEC50:  35nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595742(CHEMBL5181457)
Affinity DataEC50:  3.80nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595743(CHEMBL5207363)
Affinity DataEC50:  79nMAssay Description:Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595739(CHEMBL5178416)
Affinity DataEC50:  0.260nMAssay Description:Activation of human EAAT2 expressed in COS cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595740(CHEMBL5202745)
Affinity DataEC50:  0.800nMAssay Description:Activation of human EAAT2 expressed in COS cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595739(CHEMBL5178416)
Affinity DataEC50:  1nMAssay Description:Activation of human EAAT2 expressed in rat Astrocytes assessed as glutamate uptake by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50595740(CHEMBL5202745)
Affinity DataEC50:  0.300nMAssay Description:Activation of human EAAT2 expressed in rat Astrocytes assessed as glutamate uptake by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50: 17nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50: 17nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of EAAT2 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human EAAT2 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50: 18nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50: 18nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50632380(CHEMBL5409124)
Affinity DataIC50: 21nMAssay Description:Inhibition of human EAAT2 transfected in MDCK cells assessed as reduction in [14C]glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50: 36nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50: 36nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50: 47nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50: 47nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50632378(CHEMBL5423219)
Affinity DataIC50: 59nMAssay Description:Inhibition of human EAAT2 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410456(CHEMBL2113122)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86712(N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARA...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86712(N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARA...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410463(CHEMBL2113115)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86712(N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARA...)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50: 84nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50: 85nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86714(WAY-212922 | WAY 212922)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410461(CHEMBL2113126)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410455(CHEMBL2113116)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410457(CHEMBL2113112)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86713(WAY-213394 | WAY 213394)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50: 107nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50: 110nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86712(N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARA...)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against glutamate uptake in oocytes expressing in human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410460(CHEMBL2113121)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50173936(2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410465(CHEMBL2113113)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410459(CHEMBL2113117)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50410452(CHEMBL2113125)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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