Compile Data Set for Download or QSAR
Report error Found 1087 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2'
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM85712(1H-imidazol-4-ylacetic acid | NSC_96215 | CAS_645-...)
Affinity DataEC50:  3.10E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50000106(Piperidine-4-carboxylic acid | Piperidine-4-carbox...)
Affinity DataEC50:  6.20E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50032955(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | CH...)
Affinity DataEC50:  1.60E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50100943(3-Amino-propane-1-selenic acid | CHEMBL41065)
Affinity DataEC50:  1.40E+6nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50100946(piperidine-4-seleninic acid | Piperidine-4-selenic...)
Affinity DataEC50:  2.00E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50087272(CHEMBL34155 | P4S | Piperidine-4-sulfonic acid | P...)
Affinity DataEC50:  4.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  8.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50100944(Piperidin-4-yl-phosphinic acid | CHEMBL291079)
Affinity DataEC50:  2.70E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50058046(propofol | CHEMBL526)
Affinity DataEC50:  4.10E+3nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50105783(2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...)
Affinity DataEC50: >1.00E+5nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50105784(2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...)
Affinity DataEC50:  4.10E+3nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50105785(2-Morpholin-4-yl-propionic acid 2,6-dimethoxy-phen...)
Affinity DataEC50:  1.98E+5nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50105786(2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...)
Affinity DataEC50:  5.50E+3nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50105787(2-[Bis-(2-methoxy-ethyl)-amino]-butyric acid 2,6-d...)
Affinity DataEC50:  1.00E+4nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50058046(propofol | CHEMBL526)
Affinity DataEC50:  5.00E+4nMAssay Description:GABA-mimetic action on Oocytes expressing human alpha-1-beta-3-gamma-2L GABA-A receptor subunits at >=100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50164570(Alfaxalone | (3R,5S,8S,9S,10S,13S,14S,17S)-17-Acet...)
Affinity DataEC50:  450nMAssay Description:Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50282235(CHEMBL4174166)
Affinity DataEC50:  770nMAssay Description:Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50282234(CHEMBL4163464)
Affinity DataEC50:  250nMAssay Description:Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV hold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  2.01E+3nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259821(CHEMBL2332214)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259815(CHEMBL4090978)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259820(CHEMBL4098713)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM25883(ethyl 12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8.4...)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259824(CHEMBL475022)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259824(CHEMBL475022)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259822(CHEMBL514974)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259825(CHEMBL4089504)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259816(CHEMBL4063081)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259814(CHEMBL4062225)
Affinity DataEC50:  489nMAssay Description:Modulation of recombinant human GABA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as change in GABA-induced current at -80 mV holdin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50259814(CHEMBL4062225)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50497208(CHEMBL3289196)
Affinity DataEC50:  2.95E+4nMAssay Description:Modulation of GABAA alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50497206(CHEMBL3289195)
Affinity DataEC50:  3.47E+4nMAssay Description:Modulation of GABAA alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  1.30E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  5.20E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3(F289S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50341378(CHEBI:9921 | Valerenic Acid)
Affinity DataEC50:  1.90E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503415(CHEMBL4540194)
Affinity DataEC50:  4.10E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503416(CHEMBL4541102)
Affinity DataEC50:  9.10E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503417(CHEMBL4475525)
Affinity DataEC50:  1.00E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503418(CHEMBL4541411)
Affinity DataEC50:  5.50E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503419(CHEMBL4543496)
Affinity DataEC50:  4.40E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503420(CHEMBL4530191)
Affinity DataEC50:  6.70E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.03E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3(N265S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503422(Loreclezole | R 72063)
Affinity DataEC50:  1.10E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503423(CHEMBL4451778)
Affinity DataEC50:  4.40E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.30E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503424(CHEMBL4474746)
Affinity DataEC50:  1.20E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  2.40E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3(N265S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.71E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta3(F289S)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM246487(Batatasin III (4))
Affinity DataEC50:  6.72E+4nMAssay Description:Modulation of GABAA alpha1beta3gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 to 10 GABA-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
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