Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha'
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DatapH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of GGTase-1 in vitro using purified human enzyme to catalyze the reaction between [3H] GGPP and a biotinylated pe...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14014(CHEMBL55826 | (5S)-31-oxo-20-oxa-2,6,11,13-tetraaz...)
Affinity DataIC50: 5.5nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14713(N-[(S)-1-carbamoyl-2-phenylethyl]-4-[2-(3,4-di-chl...)
Affinity DataIC50: 8.24nMpH: 7.7 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14016(CHEMBL525368 | (5S)-6-methyl-31-oxo-20-oxa-2,6,11,...)
Affinity DataIC50: 32nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14015((5R)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50: 35nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14017((5R)-6-methyl-31-oxo-20-oxa-2,6,11,13-tetraazahexa...)
Affinity DataIC50: 39nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14012(CHEMBL523080 | (5S)-7,31-dioxo-20-oxa-2,6,11,13-te...)
Affinity DataIC50: 94nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14013((5R)-7,31-dioxo-20-oxa-2,6,11,13-tetraazahexacyclo...)
Affinity DataIC50: 150nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14023((1R,2R,5R)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: 390nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14009((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....)
Affinity DataIC50: 650nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14008((23R)-22,23,24,25-Tetrahydro-22-oxo-16H,21H-21,23-...)
Affinity DataIC50: 810nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 820nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14025(CHEMBL516874 | (1R,2R,5R)-30-oxo-19,24-dioxa-2,6,1...)
Affinity DataIC50: 1.10E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 1.60E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14011(CHEMBL497048 | (5S)-6-methyl-30-oxo-19-oxa-2,6,10,...)
Affinity DataIC50: 2.20E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14024(CHEMBL526521 | (1R,2R,5S)-30-oxo-19-oxa-2,6,10,12-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14010((5R)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....)
Affinity DataIC50: 3.90E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14021((1S,2S,5S)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: 4.00E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 5.80E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14003(Macrocyclic 3-Aminopyrrolidinone analog 27B | (20R...)
Affinity DataIC50: 7.00E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14007(CHEMBL524997 | (6R)-24-bromo-27-oxo-20-oxa-3,7,11,...)
Affinity DataIC50: 9.20E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14026(CHEMBL465417 | (1R,2R,5S)-30-oxo-19,24-dioxa-2,6,1...)
Affinity DataIC50: 1.50E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14018((17R, 20R)-19,20,21,22-Tetrahydro-19-oxo-17H-15,-1...)
Affinity DataIC50: 1.80E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14019((1S,2S,5R)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14020((1R,2R,5S)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14022((1R,2R,5R)-6-methyl-29-oxo-19-oxa-2,6,10,12-tetraa...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13998((6R)-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14005((20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-1...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14005((20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-1...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14000((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13999((6S)-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed