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Report error Found 77 Enz. Inhib. hit(s) with Target = 'Glutathione hydrolase 1 proenzyme'
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615643(CHEMBL5286162)
Affinity DataIC50: 39nMAssay Description:Inhibition of human GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615644(Crobenetine | CROBENETINE)
Affinity DataIC50: 322nMAssay Description:Inhibition of human GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208436(CHEMBL3885040)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208427(CHEMBL3884872)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM14713(N-[(S)-1-carbamoyl-2-phenylethyl]-4-[2-(3,4-di-chl...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208433(CHEMBL3885443)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208426(CHEMBL3883795)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208438(CHEMBL3885188)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248738(2-(2-Chlorophenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248772(2-(1,3-benzodioxol-5-yl)-N,N',4-trimethyl-10Hpheno...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208434(CHEMBL3884826)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248626(2-(2-Chlorophenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208431(CHEMBL3883522)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248736(2-Phenyl-N,N',4-trimethyl-10H-phenothiazine-1,3-di...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248739(2-(4-Chlorophenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248624(2-Phenyl-N,N',4-trimethyl-2,10-dihydro-1Hphenothia...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248771(2-(4-Methoxyphenyl)-N,N',4-trimethyl-10Hphenothiaz...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248625(2-(2-Methylphenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248773(2-(4-Nitrophenyl)-N,N',4-trimethyl-10Hphenothiazin...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208423(CHEMBL3884658)
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248701(2-(4-Methoxyphenyl)-N,N',4-trimethyl-2,10-dihydro-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248737(2-(2-Methylphenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208437(CHEMBL3884852)
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208430(CHEMBL3884083)
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248770(2-(2-Methoxyphenyl)-N,N',4-trimethyl-10Hphenothiaz...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248700(2-(2-Methoxyphenyl)-N,N',4-trimethyl-2,10-dihydro-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248702(2-(1,3-Benzodioxol-5-yl)-N,N',4-trimethyl-2,10-dih...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208429(CHEMBL3883400)
Affinity DataIC50: 3.19E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208435(CHEMBL3885260)
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248655(2-(4-Chlorophenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM22360(2-(acetyloxy)benzoic acid | 2-(acetyloxy)benzoate ...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50248703(2-(4-Nitrophenyl)-N,N',4-trimethyl-2,10-dihydro-1H...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of gamma-glutamyltranspeptidase by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208425(CHEMBL3884603)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208428(CHEMBL3883981)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50208432(CHEMBL3884346)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  5nMAssay Description:Inhibition of GGT1 (unknown origin) transpeptidation assessed as inhibition constant using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  5.40nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  25nMAssay Description:Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of GSH hydrolysis measured by L-glutamate release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50104413(Glutamyl-gamma-boronate analogue | CHEMBL87796)
Affinity DataKi:  25nMAssay Description:Inhibition of GGT1 (unknown origin) assessed as GSH hydrolysis by measuring inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607251(CHEMBL5219012)
Affinity DataKi:  45nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607251(CHEMBL5219012)
Affinity DataKi:  77nMAssay Description:Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of GSH hydrolysis measured by L-glutamate release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50628182(CHEMBL5400857)
Affinity DataKi:  920nMAssay Description:Inhibition of GGT1 (unknown origin) transpeptidation assessed as inhibition constant using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50628182(CHEMBL5400857)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of GGT1 (unknown origin) assessed as GSH hydrolysis by measuring inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607252(CHEMBL5219273)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607253(CHEMBL5220603)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607257(CHEMBL5219724)
Affinity DataKi:  4.90E+4nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50357212(Serine | (L)-SERINE)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of Rattus norvegicus Wistar (rat) rat Gamma-glutamyltranspeptidase using L-gamma-glutamyl-p-nitroanilide as substrate incubated for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50148335(1-Carboxy-3-[2-(carboxymethyl-carbamoyl)-ethanesul...)
Affinity DataKi:  5.30E+4nMpH: 8.0Assay Description:Compound tested for the inhibition of Gamma-glutamyltranspeptidase in rat kidney at pH 8.0 at 37 degree C (Competitive inhibition)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50607262(CHEMBL5218792)
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50628187(CHEMBL1492424)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of GGT1 (unknown origin) transpeptidation assessed as inhibition constant using L-GpNA as substrate in presence of Gly-GlyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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