Compile Data Set for Download or QSAR
Report error Found 1854 Enz. Inhib. hit(s) with Target = 'Kelch-like ECH-associated protein 1'
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006930(CHEMBL3237244)
Affinity DataKd:  16nMAssay Description:Binding affinity to biotinylated Keap1 DC domain (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  1.69E+3nMAssay Description:Binding affinity to biotinylated Keap1 DC domain (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to biotinylated Keap1 DC domain (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006930(CHEMBL3237244)
Affinity DataKd:  26nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609) expressed in Escherichia coli BL21(DE3)pLysS cells after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataEC50:  1.46E+3nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataEC50:  29nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataEC50:  395nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50130558(CHEMBL3632891)
Affinity DataKd:  69nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50130558(CHEMBL3632891)
Affinity DataKd:  25nMAssay Description:Binding affinity to the Keap1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50180850(CHEMBL3819587)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human recombinant N-terminal His6 and Avi-tagged KEAP1 (321 to 609 residues) expressed in baculovirus infected sf9 cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50180851(CHEMBL3818085 | US10144731, Example 54)
Affinity DataKd:  670nMAssay Description:Binding affinity to human recombinant N-terminal His6 and Avi-tagged KEAP1 (321 to 609 residues) expressed in baculovirus infected sf9 cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50180852(CHEMBL3819169 | US10144731, Example 136)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6 and Avi-tagged KEAP1 (321 to 609 residues) expressed in baculovirus infected sf9 cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50180853(CHEMBL3819386)
Affinity DataKd:  5.90E+4nMAssay Description:Binding affinity to human recombinant N-terminal His6 and Avi-tagged KEAP1 (321 to 609 residues) expressed in baculovirus infected sf9 cells by isoth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200465(CHEMBL3975863)
Affinity DataKd:  355nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to mouse Keap1 Kelch domain expressed in Escherichia coli BL21 by VP-ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200466(CHEMBL3913014)
Affinity DataKd:  10nMAssay Description:Binding affinity to Keap1 (unknown origin) Kelch domain by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200464(CHEMBL3982888)
Affinity DataKd:  47nMAssay Description:Binding affinity to Keap1 (unknown origin) Kelch domain by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200469(CHEMBL3946551)
Affinity DataKd:  96nMAssay Description:Binding affinity to His-tagged Keap1 (unknown origin) Kelch domain expressed in Escherichia coli BL21(DE3) pLysS by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200472(CHEMBL3966742)
Affinity DataKd:  26nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataKd:  6.00E+3nMAssay Description:Inhibition of human Keap1 kelch domain binding to Nrf2-ETGE peptide by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM335554(US9737525, Compound MIND4-17)
Affinity DataKd:  1.65E+4nMAssay Description:Binding affinity to recombinant human Keap1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataKd:  2.28E+4nMAssay Description:Binding affinity to recombinant human Keap1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50369358(CHEMBL4173296)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50369387(CHEMBL4166445)
Affinity DataKd:  103nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM561983(US11396496, Compound A1 | BDBM50369389)
Affinity DataKd:  102nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataKd:  20nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataKd:  44nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50283796(CHEMBL4174405)
Affinity DataKd:  21nMAssay Description:Binding affinity to human biotin-labeled Keap1 Kelch domain (322 to 609 residues) expressed in Escherichia coli (DE3) by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50283797(CHEMBL4169002)
Affinity DataKd:  18nMAssay Description:Binding affinity to human Keap1 Kelch domain (322 to 609 residues) expressed in Escherichia coli (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50283797(CHEMBL4169002)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to human biotin-labeled Keap1 Kelch domain (322 to 609 residues) expressed in Escherichia coli (DE3) by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50283796(CHEMBL4174405)
Affinity DataKd:  87nMAssay Description:Binding affinity to human Keap1 Kelch domain (322 to 609 residues) expressed in Escherichia coli (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200470(CHEMBL3965115)
Affinity DataKd:  47nMAssay Description:Binding affinity to Keap1 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50295169(CHEMBL4177337)
Affinity DataKd:  23nMAssay Description:Binding affinity to human Keap1 (322 to 609 residues) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502723(CHEMBL4462699 | US11479539, Compound 196)
Affinity DataEC50:  18nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502724(CHEMBL4463989 | US11479539, Compound 122)
Affinity DataEC50:  24nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502725(CHEMBL4565642 | US11479539, Compound 168)
Affinity DataEC50:  7nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502726(CHEMBL4583328 | US11479539, Compound 55)
Affinity DataEC50:  14nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502727(CHEMBL4584154 | US11479539, Compound 48)
Affinity DataEC50:  6nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502728(CHEMBL4542755 | US11479539, Compound 174)
Affinity DataEC50:  8nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502729(CHEMBL4593124 | US11479539, Compound 23)
Affinity DataEC50:  56nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502730(CHEMBL4535670)
Affinity DataEC50:  45nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502731(CHEMBL4530659)
Affinity DataEC50:  70nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502732(CHEMBL4557371 | US11479539, Compound 69)
Affinity DataEC50:  2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502733(CHEMBL4446699 | US11479539, Compound 80)
Affinity DataEC50:  2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50502734(CHEMBL4442320 | US11479539, Compound 42)
Affinity DataEC50:  33nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50491278(CHEMBL2381970)
Affinity DataKd:  7.00E+5nMAssay Description:Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109398(CHEMBL2381968)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50491279(CHEMBL2381969)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
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