Compile Data Set for Download or QSAR
Report error Found 337 Enz. Inhib. hit(s) with Target = 'Lanosterol 14-alpha demethylase'
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25806(Epiestriol | (13R,14R,15S)-15-methyltetracyclo[8.7...)
Affinity DataKd:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM24656(CHEMBL14145 | 4-phenyl-1H-imidazole | 4-Phenylimid...)
Affinity DataKd:  1.30E+6nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25807(4,4 -Dihydroxybenzophenone | 4-[(4-hydroxyphenyl)c...)
Affinity DataKd:  2.80E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25808(2,7-Dihydroxy-9-fluorenone | 2,7-dihydroxy-9H-fluo...)
Affinity DataKd:  3.75E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25809(5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,...)
Affinity DataKd:  3.75E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25810(JMC522846 Compound 5 | 2-phenyl-N-(pyridin-4-yl)bu...)
Affinity DataKd:  5.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25811(4-phenyl-N-pyridin-4-yltetrahydro-2H-pyran-4-carbo...)
Affinity DataKd:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25812(N-(4-aminophenyl)-4-chlorobenzene-1-sulfonamide | ...)
Affinity DataKd:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25813(1-(10,10a-dihydro-4aH-phenothiazin-10-yl)-2-aminoe...)
Affinity DataKd:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25814(3-furan-2-yl-3-(2-methoxyphenyl)propan-1-amine | 3...)
Affinity DataKd:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25815(2-[2-ethyl-4-(4-methoxyphenyl)-2-methyloxan-4-yl]e...)
Affinity DataKd:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25816(2-(2,1,3-benzothiadiazole-4-sulfonamido)-2-phenyl-...)
Affinity DataKd:  5.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataKd:  3.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase [F78L](Mycobacterium tuberculosis)
University of California San Francisco

LigandPNGBDBM25810(JMC522846 Compound 5 | 2-phenyl-N-(pyridin-4-yl)bu...)
Affinity DataKd:  1.95E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase [F78L](Mycobacterium tuberculosis)
University of California San Francisco

LigandPNGBDBM25816(2-(2,1,3-benzothiadiazole-4-sulfonamido)-2-phenyl-...)
Affinity DataKd:  2.32E+4nMpH: 7.5 T: 2°CAssay Description:The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  69nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataKd:  26nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50280424(1-(4-Azido-phenyl)-2-imidazol-1-yl-ethanol | CHEMB...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity for cytochrome P450 14DMMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50280425(1-(4-Azido-phenyl)-2-imidazol-1-yl-ethanone | CHEM...)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity for cytochrome P450 14DMMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50280426(1-(4-Azido-benzyl)-1H-imidazole | CHEMBL447478)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity for cytochrome P450 14DMMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50280427(1-(4-Azido-phenyl)-1H-imidazole | CHEMBL127685)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity for cytochrome P450 14DMMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM31774(cid_2812 | CHEMBL104 | Canesten | Mycelex | Lotrim...)
Affinity DataKd:  200nMAssay Description:Binding affinity to Mycobacterium tuberculosis CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM31773(ECONAZOLE | cid_68589 | Pevaryl | Gyno-pevaryl | E...)
Affinity DataKd:  200nMAssay Description:Binding affinity to Mycobacterium tuberculosis CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataKd:  200nMAssay Description:Binding affinity to Mycobacterium tuberculosis CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Francisco

LigandPNGBDBM31772(Brentan | 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dich...)
Affinity DataKd:  200nMAssay Description:Binding affinity to Mycobacterium tuberculosis CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to human CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKd:  110nMAssay Description:Binding affinity to human CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKd:  110nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375211(CHEMBL535872)
Affinity DataKd:  340nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375212(CHEMBL558189)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375213(CHEMBL537002)
Affinity DataKd:  400nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375214(CHEMBL536772)
Affinity DataKd:  2.60E+5nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375215(CHEMBL538591)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375216(CHEMBL537231)
Affinity DataKd:  3.50E+4nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375217(CHEMBL537003)
Affinity DataKd:  2.92E+4nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50375218(CHEMBL557376)
Affinity DataKd:  2.70E+4nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataKd:  1.20E+5nMAssay Description:Binding affinity to human CYP51More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKd:  165nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276213(CHEMBL4127493)
Affinity DataKd:  13nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataKd:  290nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276214(CHEMBL4129161)
Affinity DataKd:  13nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276215(CHEMBL4128885)
Affinity DataKd:  10nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276218(CHEMBL4128615)
Affinity DataKd:  25nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50276219(CHEMBL4126063)
Affinity DataKd:  95nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50181473(CHEMBL1397 | 4-(4-(4-(4-(((5R)-5-((1H-1,2,4-triazo...)
Affinity DataKd:  81nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50505758(CHEMBL4444489)
Affinity DataKd:  470nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50505759(CHEMBL4593688)
Affinity DataKd:  1.15E+3nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM50505760(CHEMBL4458275)
Affinity DataKd:  1.65E+3nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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