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Report error Found 670 Enz. Inhib. hit(s) with Target = 'Lysosomal alpha-glucosidase'
TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataEC50:  9.88E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM18353((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Affinity DataEC50:  7.45E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataEC50:  1.18E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190528(US9181184, 11)
Affinity DataEC50:  4.77E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190529(US9181184, 15)
Affinity DataEC50:  5.84E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190530(US9181184, 16)
Affinity DataEC50:  6.97E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190531(US9181184, 17 | US9181184, 18)
Affinity DataEC50:  6.53E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190531(US9181184, 17 | US9181184, 18)
Affinity DataEC50:  1.04E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190533(US9181184, 19)
Affinity DataEC50:  3.72E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190534(US9181184, 20)
Affinity DataEC50:  4.68E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190535(US9181184, 21)
Affinity DataEC50:  2.10E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190536(US9181184, 23)
Affinity DataEC50:  1.21E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190537(US9181184, 24)
Affinity DataEC50:  7.71E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190538(US9181184, 25)
Affinity DataEC50:  6.65E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190539(US9181184, 26)
Affinity DataEC50:  6.60E+3nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM190540(US9181184, 27)
Affinity DataEC50:  1.73E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM18364(CN-DNJ | (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nony...)
Affinity DataEC50:  7.00E+3nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Mouse)
Amicus Therapeutics

US Patent
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataEC50:  2.81E+5nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398032(CHEMBL1603014)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50398020(CHEMBL2181103)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50283602(6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity was determined against baker's yeast Alpha-GlucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50065252(2,6-Bis-hydroxymethyl-1-methyl-piperidine-3,4,5-tr...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 60nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 70nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 100nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50048087(CHEMBL3311516)
Affinity DataIC50: 110nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 110nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 120nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 120nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM628474(US20230339856, Compound (IId))
Affinity DataIC50: 150nMAssay Description:The rhGAA enzyme sold under the name Myozyme used comes from residues of perfusions of the recombinant enzyme used for treating, by enzyme therapy, t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333465((2R,3R,4R,5S,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Wistar rat small intestine maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 170nMAssay Description:Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50048088(CHEMBL3311517)
Affinity DataIC50: 170nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50048089(CHEMBL3311518)
Affinity DataIC50: 180nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333465((2R,3R,4R,5S,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 180nMAssay Description:Inhibition of Wistar rat small intestine maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333465((2R,3R,4R,5S,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Affinity DataIC50: 180nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50399654(CHEMBL2177691)
Affinity DataIC50: 190nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50596693(CHEMBL5189075)
Affinity DataIC50: 190nMAssay Description:Inhibition of rat intestinal maltase assessed as release of D-glucose using maltose as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Wistar rat small intestine maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat small intestinal maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50612995(CHEMBL5276586)
Affinity DataIC50: 200nMAssay Description:Inhibition of maltase in rat small intestinal brush border membrane vesicles using maltose as substrate incubated for 30 mins by glucose-oxidase meth...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50399655(CHEMBL2177690)
Affinity DataIC50: 220nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50399655(CHEMBL2177690)
Affinity DataIC50: 220nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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