Compile Data Set for Download or QSAR
Found 11 Enz. Inhib. hit(s) with Target = 'NADPH--cytochrome P450 reductase'
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236853(CHEMBL4094677)
Show SMILES Cc1coc-2c1C(=O)C(=O)c1ccc(C)cc-21
Show InChI InChI=1S/C14H10O3/c1-7-3-4-9-10(5-7)14-11(8(2)6-17-14)13(16)12(9)15/h3-6H,1-2H3
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236859(CHEMBL4086536)
Show SMILES Cc1cc2-c3occc3C(=O)C(=O)c2cc1C
Show InChI InChI=1S/C14H10O3/c1-7-5-10-11(6-8(7)2)14-9(3-4-17-14)12(15)13(10)16/h3-6H,1-2H3
Affinity DataIC50: 9.00E+3nMAssay Description:Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated ...More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM81348(β-Lapachone (A3) | Beta lapachone | R115 (Rea...)
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
Affinity DataIC50: 1.10E+4nMAssay Description:Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated ...More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236854(CHEMBL4074173)
Show SMILES Cc1coc-2c1C(=O)C(=O)c1c(C)ccc(C)c-21
Show InChI InChI=1S/C15H12O3/c1-7-4-5-8(2)11-10(7)13(16)14(17)12-9(3)6-18-15(11)12/h4-6H,1-3H3
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236863(CHEMBL3398294)
Show SMILES COc1cccc2C(=O)C(=O)C3=C(OC(C)C3(C)C)c12
Show InChI InChI=1S/C16H16O4/c1-8-16(2,3)12-14(18)13(17)9-6-5-7-10(19-4)11(9)15(12)20-8/h5-8H,1-4H3
Affinity DataIC50: 1.90E+4nMAssay Description:Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated ...More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236858(CHEMBL4098063)
Show SMILES CCc1coc-2c1C(=O)C(=O)c1cc(C)c(C)cc-21
Show InChI InChI=1S/C16H14O3/c1-4-10-7-19-16-12-6-9(3)8(2)5-11(12)14(17)15(18)13(10)16/h5-7H,4H2,1-3H3
Affinity DataIC50: 1.90E+4nMAssay Description:Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aMore data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236857(CHEMBL4080037)
Show SMILES Cc1coc-2c1C(=O)C(=O)c1cc(C)ccc-21
Show InChI InChI=1S/C14H10O3/c1-7-3-4-9-10(5-7)12(15)13(16)11-8(2)6-17-14(9)11/h3-6H,1-2H3
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236860(CHEMBL4065098)
Show SMILES CCc1coc-2c1C(=O)C(=O)c1cc(C)ccc-21
Show InChI InChI=1S/C15H12O3/c1-3-9-7-18-15-10-5-4-8(2)6-11(10)13(16)14(17)12(9)15/h4-7H,3H2,1-2H3
Affinity DataIC50: 2.50E+4nMAssay Description:Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aMore data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236861(CHEMBL3398292)
Show SMILES COc1ccc2C3=C(C(=O)C(=O)c2c1)C(C)(C)C(C)O3
Show InChI InChI=1S/C16H16O4/c1-8-16(2,3)12-14(18)13(17)11-7-9(19-4)5-6-10(11)15(12)20-8/h5-8H,1-4H3
Affinity DataIC50: 3.00E+4nMAssay Description:Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated ...More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236862(CHEMBL3398293)
Show SMILES COc1ccc2C(=O)C(=O)C3=C(OC(C)C3(C)C)c2c1
Show InChI InChI=1S/C16H16O4/c1-8-16(2,3)12-14(18)13(17)10-6-5-9(19-4)7-11(10)15(12)20-8/h5-8H,1-4H3
Affinity DataIC50: 3.20E+4nMAssay Description:Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated ...More data for this Ligand-Target Pair
TargetNADPH--cytochrome P450 reductase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236855(CHEMBL4102425)
Show SMILES Cc1coc-2c1C(=O)C(=O)c1cc(C)c(C)cc-21
Show InChI InChI=1S/C15H12O3/c1-7-4-10-11(5-8(7)2)15-12(9(3)6-18-15)14(17)13(10)16/h4-6H,1-3H3
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2; Maximum inhibition reached only 50%More data for this Ligand-Target Pair