Compile Data Set for Download or QSAR
Report error Found 1033 Enz. Inhib. hit(s) with Target = 'Peptidyl-prolyl cis-trans isomerase FKBP1A'
LigandPNGBDBM50284189(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  9.20nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284192(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  7nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284198(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  5.70nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284197((E)-(9S,12S,13R,14S,17R,21S,23S,24R,25S,27S)-12-[(...)
Affinity DataEC50:  2.70nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284193((E)-(9S,12S,13R,14S,17R,21S,23S,24R,25S,27S)-12-[(...)
Affinity DataEC50:  6.10nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284194(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  6.60nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50068939(CHEMBL8597 | 17-Ethyl-1,14-dihydroxy-12-[2-(4-hydr...)
Affinity DataEC50:  1.60nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PDB3D3D Structure (crystal)
LigandPNGBDBM50284187(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  16nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284196(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  15nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284186(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  4.60nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284188(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  12nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284190(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  10nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284195(C32-O-cinnamyl ether analogue of L-683590 | CHEMBL...)
Affinity DataEC50:  12nMAssay Description:Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50071450(Ascomycin derivative | CHEMBL385568)
Affinity DataEC50:  12nMAssay Description:Binding affinity for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50071463(C32-O-cinnamyl ether analogue of L-683590 | Ascomy...)
Affinity DataEC50:  30nMAssay Description:Binding affinity for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50068939(CHEMBL8597 | 17-Ethyl-1,14-dihydroxy-12-[2-(4-hydr...)
Affinity DataEC50:  1.60nMAssay Description:Binding affinity for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50071466(Ascomycin derivative | CHEMBL386482)
Affinity DataEC50:  7.40nMAssay Description:Binding affinity for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50071465(Ascomycin derivative | CHEMBL428499)
Affinity DataEC50:  22nMAssay Description:Binding affinity for FK506 binding protein 12 using [3H]-dihydro FK-506 radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079766(C32-O-Phenalkyl ether derivative of Ascomycin | 17...)
Affinity DataEC50:  12nMAssay Description:Effective concentration determined was towards FK506 binding protein 12 by competitive binding assay using [3H]-dihydro FK-506 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079767(C32-O-Phenalkyl ether derivative of Ascomycin | C3...)
Affinity DataEC50:  32nMAssay Description:Effective concentration determined was towards FK506 binding protein 12 by competitive binding assay using [3H]-dihydro FK-506 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079765(C32-O-Phenalkyl ether derivative of Ascomycin | C3...)
Affinity DataEC50:  5.30nMAssay Description:Effective concentration determined was towards FK506 binding protein 12 by competitive binding assay using [3H]-dihydro FK-506 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50068939(CHEMBL8597 | 17-Ethyl-1,14-dihydroxy-12-[2-(4-hydr...)
Affinity DataEC50:  1.60nMAssay Description:Effective concentration determined was towards FK506 binding protein 12 by competitive binding assay using [3H]-dihydro FK-506 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50079770(C32-O-Phenalkyl ether derivative of Ascomycin | CH...)
Affinity DataEC50:  9.20nMAssay Description:Effective concentration determined was towards FK506 binding protein 12 by competitive binding assay using [3H]-dihydro FK-506 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079779(17-Ethyl-1,14-dihydroxy-12-{2-[4-(2-hydroxy-2-naph...)
Affinity DataEC50:  18nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079781(12-(2-{4-[2-(3,4-Difluoro-phenyl)-2-hydroxy-ethoxy...)
Affinity DataEC50:  14nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079776(17-Ethyl-1,14-dihydroxy-12-(2-{4-[2-hydroxy-2-(3-t...)
Affinity DataEC50:  45nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079774(12-(2-{4-[2-(3,5-Dimethyl-phenyl)-2-hydroxy-ethoxy...)
Affinity DataEC50:  9nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079780(12-(2-{4-[2-(3,5-Dimethyl-phenyl)-2-hydroxy-ethoxy...)
Affinity DataEC50:  7.5nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079782(17-Ethyl-1,14-dihydroxy-12-(2-{4-[2-hydroxy-2-(3-t...)
Affinity DataEC50:  45nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079783(12-{2-[4-(2-Benzo[b]thiophen-2-yl-2-hydroxy-ethoxy...)
Affinity DataEC50:  12nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079775(17-Ethyl-1,14-dihydroxy-12-{2-[4-(2-hydroxy-2-naph...)
Affinity DataEC50:  21nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079784(12-{2-[4-(2-Benzo[b]thiophen-2-yl-2-hydroxy-ethoxy...)
Affinity DataEC50:  11nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079777((E)-(1R,9S,12S,13R,14R,21S,23S,24R,25S,27R)-17-All...)
Affinity DataEC50:  0.900nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079778(12-(2-{4-[2-(3,4-Difluoro-phenyl)-2-hydroxy-ethoxy...)
Affinity DataEC50:  7.5nMAssay Description:Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228089(N-(4-fluorophenyl)piperidine-1-sulfonamide | CHEMB...)
Affinity DataKd:  3.19E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228090(1-morpholino-2-(p-tolylthio)ethanone | CHEMBL23638...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228092(1-(3-(trifluoromethyl)benzyl)-2-(thiazol-4-yl)-1H-...)
Affinity DataKd: >3.00E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228091(2-(4'-methyl-biphenyl-4-yloxy)-1-morpholin-4-yl-et...)
Affinity DataKd:  7.55E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228099(benzyl 2-methyl-4-(2-morpholino-2-oxoethoxy)phenyl...)
Affinity DataKd: >1.50E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228097(N-(3,5-dimethylphenyl)piperidine-1-sulfonamide | C...)
Affinity DataKd: >1.86E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228093(2-(4-methoxyphenoxy)-1-morpholinoethanone | CHEMBL...)
Affinity DataKd:  3.57E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228098(2-(2-chlorophenoxy)-1-(2,6-dimethylmorpholino)etha...)
Affinity DataKd: >5.00E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228095(2-(4-fluorophenoxy)-1-morpholinoethanone | CHEMBL2...)
Affinity DataKd:  5.76E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228094(CHEMBL235260 | cid_1520613 | N-(2-(methylthio)phen...)
Affinity DataKd: >4.00E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228096(CHEMBL393826 | cid_1266440 | N-(2-fluorophenyl)-2-...)
Affinity DataKd: >4.00E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228100(1-(2,6-dimethylmorpholino)-2-(phenylthio)ethanone ...)
Affinity DataKd:  7.26E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228103(N-(3,5-dichlorophenyl)piperidine-1-sulfonamide | C...)
Affinity DataKd:  1.55E+5nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228101(2,2-difluoro-2-(4-isopropylphenylthio)-1-morpholin...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228102(1-morpholino-2-(2,3,5-trimethylphenoxy)ethanone | ...)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228104(4-(1H-benzo[d]imidazol-2-yl)thiazol-2-amine | CHEM...)
Affinity DataKd:  9.80E+4nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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