Compile Data Set for Download or QSAR
Report error Found 1327 Enz. Inhib. hit(s) with Target = 'Polycomb protein EED'
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKd:  1.5nMpH: 7.4 T: 2°CAssay Description:SPR studies were performed using a Biacore T200 (GE Health Sciences Inc.) at 20 °C. Approximately 8,400 response units (RU) of biotinylated EED was c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241645(CHEMBL4078052)
Affinity DataKd:  210nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241646(CHEMBL4102320)
Affinity DataKd:  43nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241647(CHEMBL4067115)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235626(CHEMBL4075197)
Affinity DataKd:  150nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241648(CHEMBL4072980)
Affinity DataKd:  140nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235656(CHEMBL4085375)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241649(CHEMBL4093134)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241650(CHEMBL4100850)
Affinity DataKd:  61nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241652(CHEMBL4074086)
Affinity DataKd:  1.34E+4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235631(CHEMBL4060827)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241647(CHEMBL4067115)
Affinity DataKd:  370nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241653(CHEMBL4093678)
Affinity DataKd:  940nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241648(CHEMBL4072980)
Affinity DataKd:  30nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50127824(2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline | C...)
Affinity DataKd:  5.20E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241655(CHEMBL4071358)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241656(CHEMBL4092154)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241657(CHEMBL4077899)
Affinity DataKd:  110nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKd:  10nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241658(CHEMBL4064198)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241655(CHEMBL4071358)
Affinity DataKd:  100nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241656(CHEMBL4092154)
Affinity DataKd:  290nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241657(CHEMBL4077899)
Affinity DataKd:  200nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKd:  3.80E+4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235648(CHEMBL4081496)
Affinity DataKd:  20nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235631(CHEMBL4060827)
Affinity DataKd:  4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241659(CHEMBL4079004)
Affinity DataKd:  300nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241653(CHEMBL4093678)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241661(CHEMBL4103307)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50127824(2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline | C...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50235626(CHEMBL4075197)
Affinity DataKd:  90nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241660(CHEMBL4084398)
Affinity DataKd:  10nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKd:  6nMAssay Description:Binding affinity to His tagged human EED (77 to 441 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241660(CHEMBL4084398)
Affinity DataKd:  1nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataKd:  2nMAssay Description:Binding affinity to biotin labelled human EED (78 to 441 residues) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282114(CHEMBL4160235)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282161(CHEMBL4175336)
Affinity DataKd:  1.09E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataKd:  680nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282164(CHEMBL4164708)
Affinity DataKd:  8.80E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50282165(CHEMBL4168151)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMAssay Description:Binding affinity to EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50259900(CHEMBL4101947)
Affinity DataKd:  3.20E+4nMAssay Description:Binding affinity to human methionine-13Cepsilon-methyl labeled PRC2-EED (76 to 441 residues) expressed in Escherichia coli BL21 (DE3) by 2D NMR metho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataKd:  400nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563656(CHEMBL4754048)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563657(CHEMBL4762963)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563658(CHEMBL4748924)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563659(CHEMBL4759335)
Affinity DataKd:  500nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM50563660(CHEMBL4752420)
Affinity DataKd:  3.05E+5nMAssay Description:Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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