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Found 17916 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095768(CHEMBL3590463)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50214370(CHEMBL227134 | N-(4-{2-[[2-(4-methanesulfonylamino...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM89440(4-(4-chlorophenyl)butyl-diethyl-heptyl-ammonium;to...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319962((1S,4S)-2-(5-(benzo[b]thiophen-5-yl)pyridin-2-yl)-...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319955((1S,4S)-2-(5-(benzo[b]thiophen-5-yl)pyrimidin-2-yl...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50314264((-)-(R)-2-(1-(2-(2-(azetidin-1-yl)ethyl)benzo[b]th...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319947((1S,4S)-2-(5-(benzo[b]thiophen-5-yl)pyrazin-2-yl)-...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50333952(CHEMBL1644470 | exo-(1R,5S)-3-(6-phenylpyridin-2-y...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319954((1S,4S)-2-(5-(benzofuran-5-yl)pyrimidin-2-yl)-5-me...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095652(CHEMBL3590452)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095764(CHEMBL3140084)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319938((1S,4S)-2-(6-(benzo[b]thiophen-5-yl)pyridazin-3-yl...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319958(5-(2-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  1.85nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319950(5-(5-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319965(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319941(5-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319961((1S,4S)-2-(5-(benzofuran-5-yl)pyridin-2-yl)-5-meth...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319967(6-(6-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095769(CHEMBL3590465)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50427971(CHEMBL2325208)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50214364(11-ethyl-1-(3-{[2-(4-methanesulfonylamino-phenoxy)...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095642(CHEMBL3590446)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319957(5-(2-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315675(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)py...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315688(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50352338(CHEMBL1822858)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50314265(CHEMBL1091776 | N,N-dimethyl-2-(3-(1-(pyridin-3-yl...)
Affinity DataKi: >5nMAssay Description:Displacement of [3H]Dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50297309((-)-(R)-N,N-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)b...)
Affinity DataKi: >5nMAssay Description:Displacement of [3H]Dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315674(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)py...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315676(((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-p...)
Affinity DataKi: >5.30nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319946((1S,4S)-2-(5-(benzofuran-5-yl)pyrazin-2-yl)-5-meth...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315686(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315677(((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50427960(CHEMBL2324244)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315680(((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50214372(24-{[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315681(((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrroli...)
Affinity DataKi: >7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50378743(CHEMBL1204061)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50352335(CHEMBL1822861)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50095760(CHEMBL3093959)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319937((1S,4S)-2-(6-(benzofuran-5-yl)pyridazin-3-yl)-5-me...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319952(6-(5-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315679(((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrro...)
Affinity DataKi: >9.20nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50494716(CHEMBL3093986)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50319960((1S,4S)-2-methyl-5-(5-phenylpyridin-2-yl)-2,5-diaz...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50325744(CHEMBL1223683 | N-(4-(4-(2,3-dichlorophenyl)pipera...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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