Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with Target = 'Protein phosphatase 3 catalytic subunit alpha'
LigandPNGBDBM50285470((9S,11R,19R,20R,23R)-3-Hydroxy-9-methoxy-11,14,19-...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50030448(CHEMBL269732 | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN ...)
Affinity DataKd:  20nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKd:  4nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50285472(18-(E)-allyl-11,21-Dihydroxy-23-[2-((R)-4-hydroxy-...)
Affinity DataKd:  350nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50285474((E)-18-Allyl-11,21-dihydroxy-23-[(E)-2-((R)-4-hydr...)
Affinity DataKd:  300nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50285471((9S,11R,19R,20R,23R)-15-sec-Butyl-9-methoxy-11,14,...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50285473((8S,10R,18R,19R,22R)-8-Methoxy-10,13,18-trimethyl-...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
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LigandPNGBDBM50079775(17-Ethyl-1,14-dihydroxy-12-{2-[4-(2-hydroxy-2-naph...)
Affinity DataIC50: 2.80nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079784(12-{2-[4-(2-Benzo[b]thiophen-2-yl-2-hydroxy-ethoxy...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079783(12-{2-[4-(2-Benzo[b]thiophen-2-yl-2-hydroxy-ethoxy...)
Affinity DataIC50: 4.20nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079776(17-Ethyl-1,14-dihydroxy-12-(2-{4-[2-hydroxy-2-(3-t...)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079782(17-Ethyl-1,14-dihydroxy-12-(2-{4-[2-hydroxy-2-(3-t...)
Affinity DataIC50: 5.90nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079770(C32-O-Phenalkyl ether derivative of Ascomycin | CH...)
Affinity DataIC50: 7.20nMAssay Description:Concentration required for inhibition of serine/threonine protein phosphatase calcineurin (CAN)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50079779(17-Ethyl-1,14-dihydroxy-12-{2-[4-(2-hydroxy-2-naph...)
Affinity DataIC50: 7.30nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079778(12-(2-{4-[2-(3,4-Difluoro-phenyl)-2-hydroxy-ethoxy...)
Affinity DataIC50: 7.30nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50079780(12-(2-{4-[2-(3,5-Dimethyl-phenyl)-2-hydroxy-ethoxy...)
Affinity DataIC50: 7.90nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079781(12-(2-{4-[2-(3,4-Difluoro-phenyl)-2-hydroxy-ethoxy...)
Affinity DataIC50: 8.70nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079774(12-(2-{4-[2-(3,5-Dimethyl-phenyl)-2-hydroxy-ethoxy...)
Affinity DataIC50: 8.70nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50079767(C32-O-Phenalkyl ether derivative of Ascomycin | C3...)
Affinity DataIC50: 14nMAssay Description:Concentration required for inhibition of serine/threonine protein phosphatase calcineurin (CAN)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50079777((E)-(1R,9S,12S,13R,14R,21S,23S,24R,25S,27R)-17-All...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Calcineurin (CaN phosphatase)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 49nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 75nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 89nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 135nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 140nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 183nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50123742(Cyclosporin A analogue | CHEMBL412946)
Affinity DataIC50: 348nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (morn)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 358nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123747(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 363nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123748(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 581nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123744(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 636nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123738(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 742nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (morn)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123741(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 840nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123743(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 890nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123746(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 1.54E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123738(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 1.92E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (MOM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123742(Cyclosporin A analogue | CHEMBL412946)
Affinity DataIC50: 2.15E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assay (MTM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123739(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 5.00E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123740(6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopr...)
Affinity DataIC50: 5.00E+3nMAssay Description:Compound was evaluated for its inhibitory activity in a calcineurin inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against (calcineurin) was determinedMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM21280(N-(1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibitory activity against (calcineurin) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed