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Report error Found 10521 Enz. Inhib. hit(s) with Target = 'Prothrombin'
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM21740(2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,4...)
Affinity DatapH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23547(6,8-dichloro-2-oxo-N-phenyl-2H-chromene-3-carboxam...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23565(6,8-dichloro-N-(3-methylphenyl)-2-oxo-2H-chromene-...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23548(8-bromo-6-chloro-2-oxo-N-phenyl-2H-chromene-3-carb...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23536(N-cyclododecyl-6-methyl-2-oxo-2H-chromene-3-carbox...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23537(N-(adamantan-1-yl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23539(N-benzyl-6-methyl-2-oxo-2H-chromene-3-carboxamide ...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23540(6-methyl-2-oxo-N-(2-phenylethyl)-2H-chromene-3-car...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23542(6-methyl-2-oxo-N-(quinolin-3-yl)-2H-chromene-3-car...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23543(2-oxo-N-phenyl-2H-chromene-3-carboxamide | JMC5219...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23545(6-nitro-2-oxo-N-phenyl-2H-chromene-3-carboxamide |...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23546(6-bromo-2-oxo-N-phenyl-2H-chromene-3-carboxamide |...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23556(N-(3-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23708(4-bromo-1-[(2,6-difluorophenyl)carbonyl]-1H-pyrazo...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23713(4-chloro-1-[(2-methylphenyl)carbonyl]-1H-pyrazole ...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23714(4-bromo-1-[(3-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23715(4-bromo-1-[(2-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23716(N-{4-[(3-methyl-1H-pyrazol-1-yl)carbonyl]phenyl}ac...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23717(4-chloro-1-[(2-chlorophenyl)carbonyl]-1H-pyrazole ...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23718(1-[(2-methylphenyl)carbonyl]-1H-pyrazole | N-Benzo...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23719(4-bromo-1-[(2-chloro-4,5-difluorophenyl)carbonyl]-...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23720(1-[(4-tert-butylphenyl)carbonyl]-4-chloro-1H-pyraz...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23723(cid_714833 | 4-bromo-1-[(4-methoxyphenyl)carbonyl]...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23724(1-[(2-bromophenyl)carbonyl]-1H-pyrazole | N-Benzoy...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  49nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046342(2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin...)
Affinity DataEC50:  840nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046344(1-(3-Oxo-3-phenyl-propionyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  590nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046348(1-(4-Oxo-4-pyridin-3-yl-butyryl)-pyrrolidine-2-car...)
Affinity DataEC50:  1.17E+3nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046346(1-(2-Oxo-5-phenyl-pentanoyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  880nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046349(1-(4-Cyclohexyl-butyryl)-pyrrolidine-2-carboxylic ...)
Affinity DataEC50:  5.60E+4nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046347(1-(4-Oxo-4-thiophen-2-yl-butyryl)-pyrrolidine-2-ca...)
Affinity DataEC50:  590nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046350(1-(4-Cyclohexyl-4-oxo-butyryl)-pyrrolidine-2-carbo...)
Affinity DataEC50:  150nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50003738(CHEMBL135723 | (lactone 2)N-[4-(6-Iodomethylene-2-...)
Affinity DataKon:  0.000220M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50003742(CHEMBL335908 | N-[4-(6-Methylene-2-oxo-tetrahydro-...)
Affinity DataKon:  0.000100M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  50nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  390nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50455289(CHEMBL4212514)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human fluorescence labelled FPRCK-alpha thrombin by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50455284(CHEMBL4210645)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to wild-type thrombin (unknown origin) by intrinsic fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50455284(CHEMBL4210645)
Affinity DataKd:  3.70E+3nMAssay Description:Binding affinity to human fluorescence labelled FPRCK-alpha thrombin by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50125842(5-amino(imino)methylamino-2-[1-[2-amino-3-phenyl-(...)
Affinity DataKd:  575nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50481924(CHEMBL1077164)
Affinity DataKd:  0.210nMAssay Description:Binding affinity to human thrombin after 30 mins by non-equilibrium capillary electrophoresisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50481925(CHEMBL1077163)
Affinity DataKd:  0.270nMAssay Description:Binding affinity to human thrombin after 30 mins by non-equilibrium capillary electrophoresisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50481926(CHEMBL1077162)
Affinity DataKd:  0.180nMAssay Description:Binding affinity to human thrombin after 30 mins by non-equilibrium capillary electrophoresisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50481927(CHEMBL1077161)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to human thrombin after 30 mins by non-equilibrium capillary electrophoresisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50511167(CHEMBL4563187)
Affinity DataKd:  916nMAssay Description:Binding affinity to human alpha-thrombin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
University of Namur

LigandPNGBDBM50511168(CHEMBL4465587)
Affinity DataKd:  3.68E+3nMAssay Description:Binding affinity to human alpha-thrombin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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