Compile Data Set for Download or QSAR
Report error Found 70 Enz. Inhib. hit(s) with Target = 'Sphingomyelin phosphodiesterase 2'
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407385(CHEMBL5284450)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407382(CHEMBL5280187)
Affinity DataIC50: 860nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407379(CHEMBL5276486)
Affinity DataIC50: 900nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against schyphostatin of neutral sphingomyelinase (N-SMase) from bovine brain microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against neutral sphingomyelinase (N-Smase) from rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407378(CHEMBL1514251)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat brain nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407383(CHEMBL5278618)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128902(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-3-hyd...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128902(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-3-hyd...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407376(CHEMBL5284579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of nSMase in human U-937 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128892(Pyridin-3-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407381(CHEMBL5285219)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50407380(CHEMBL5279211)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128891(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128891(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407377(CHEMBL5270975)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of nSMase in human U-937 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128891(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134343(N-[(E)-(1S,2R)-2-Hydroxy-1-(3-pyridin-4-ylmethyl-u...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128908((2-Dimethylamino-ethyl)-carbamic acid (E)-(2S,3R)-...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407375(CHEMBL5285849)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128903((3-Dimethylamino-propyl)-carbamic acid (E)-(2S,3R)...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407373(CHEMBL2365779)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128898(Pyridin-2-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134339(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134340(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-(2,...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128906(Pyridin-2-yl-carbamic acid (E)-(2S,3R)-2-(2,2-dime...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128905((4-Dimethylamino-benzyl)-carbamic acid (E)-(2S,3R)...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407371(CHEMBL5284730)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128900((2-Pyridin-2-yl-ethyl)-carbamic acid (E)-(2S,3R)-2...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128896({2-[(E)-(2S,3R)-2-(2,2-Dimethyl-propionylamino)-3-...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407370(CHEMBL5281448)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50407369(CHEMBL5288641)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128904((2-Diisopropylamino-ethyl)-carbamic acid (E)-(2S,3...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134345((2S,3R)-2-[(2,2-dimethylpropanoyl)amino]-3-hydroxy...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50221658(CHEMBL110491)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibitory activity against NSMase (neutral sphingomyelinase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingomyelin phosphodiesterase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50221662(CHEMBL320658)
Affinity DataIC50: 2.77E+4nMAssay Description:Inhibitory activity against NSMase (neutral sphingomyelinase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128895(4-Dimethylamino-butyric acid (E)-(2S,3R)-2-(2,2-di...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407368(CHEMBL444672)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50134344(N-[(E)-(1S,2R)-2-Hydroxy-1-(3-pyridin-4-ylmethyl-t...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50: 4.93E+4nMAssay Description:Inhibitory concentration against neutral sphingomyelinase (N-Smase) from rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134341([(E)-(2S,3R)-2-(2,2-Dimethyl-propionylamino)-3-hyd...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128897((3,3-Dimethyl-butyl)-carbamic acid (E)-(2S,3R)-2-(...)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50128907(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-2-ace...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128901(Pyridin-4-ylmethyl-carbamic acid (E)-(2S,3R)-3-hyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat brain microsomes nSMaseMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50128899((S)-Pyridin-4-ylmethyl-carbamic acid (R)-2-amino-3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against the membrane neutral magnesium-dependent Sphingomyelinase (N-SMase) using rat brain microsomes as the enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134338(Pyridin-4-ylmethyl-carbamic acid (2S,3R)-2-(2,2-di...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134342(Pyridin-4-ylmethyl-carbamic acid (2S,3R)-2-(2,2-di...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against N-SMase (neutral magnesium- dependent-sphingomyelinase) using rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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