Compile Data Set for Download or QSAR
Report error Found 3003 Enz. Inhib. hit(s) with Target = 'Stromelysin-1'
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DatapH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121943(4'-Hydroxy-biphenyl-4-carbonitrile | CHEMBL114523)
Affinity DataKd:  2.00E+4nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataKd:  5.00E+4nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50056900(2-Carbamoylphenol | 2-Carboxamidophenol | 2-Hydrox...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121952(Ethyl hydroxycarbamate | CHEMBL153081)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121955(4-Phenyl-pyridine | CHEMBL109074 | US11634391, Com...)
Affinity DataKd:  1.70E+5nMAssay Description:Binding to stromelysin (MMP-3) in the presence of acetohydroxamic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121958([1,1'-biphenyl]-4,4'-diol | biphenyl-4,4'-diol | 4...)
Affinity DataKd:  1.50E+5nMAssay Description:Binding to stromelysin (MMP-3) in the presence of 1-NapthohydroxamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121956(4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester | C...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121957(Thiophen-2-yl-methanethiol | CHEMBL152603)
Affinity DataKd:  1.50E+5nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121953(3-sulfanylpropanoic acid | 3-mercaptopropanoic aci...)
Affinity DataKd:  3.00E+6nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50099857(acetohydroxamic acid | AHA | Acethydroxamsaeure | ...)
Affinity DataKd:  1.70E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121955(4-Phenyl-pyridine | CHEMBL109074 | US11634391, Com...)
Affinity DataKd:  9.00E+5nMAssay Description:Binding to stromelysin (MMP-3) in the presence of 1-NapthohydroxamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121958([1,1'-biphenyl]-4,4'-diol | biphenyl-4,4'-diol | 4...)
Affinity DataKd:  1.60E+5nMAssay Description:Binding to stromelysin (MMP-3) in the presence of acetohydroxamic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50015184(benzoyl hydroxamic acid | CHEMBL16300 | BENZHYDROX...)
Affinity DataKd:  7.00E+6nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50026891(1-Pyridin-2-yl-ethanone | CHEMBL11945)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121960(4,4,4-trifluoro-1-phenylbutane-1,3-dione | 4,4,4-T...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50099857(acetohydroxamic acid | AHA | Acethydroxamsaeure | ...)
Affinity DataKd:  1.70E+7nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50121943(4'-Hydroxy-biphenyl-4-carbonitrile | CHEMBL114523)
Affinity DataKd:  2.00E+4nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50015152(CHEMBL115468 | Naphthalene-1-carboxylic acid hydro...)
Affinity DataKd:  5.00E+4nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50149238(p-biphenylol | p-hydroxybiphenyl | p-hydroxydiphen...)
Affinity DataKd:  2.80E+5nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50149241((4'-Hydroxy-biphenyl-3-yl)-acetonitrile | CHEMBL11...)
Affinity DataKd:  2.00E+4nMAssay Description:Dissociation constant for Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DataKd:  43nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKd:  113nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataKd:  100nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50305115(5-(4'-cyanobiphenyl-4-yloxy)-N-hydroxypentanamide ...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DataKd:  7nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKd:  43nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataKd:  110nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50305115(5-(4'-cyanobiphenyl-4-yloxy)-N-hydroxypentanamide ...)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50149238(p-biphenylol | p-hydroxybiphenyl | p-hydroxydiphen...)
Affinity DataKd:  2.80E+5nMAssay Description:Binding affinity to human MMP3 catalytic domain (81 to 256 residues) expressed in Escherichia coli BL21 (DE3) pLysS by 15N-HSQC-NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50099857(acetohydroxamic acid | AHA | Acethydroxamsaeure | ...)
Affinity DataKd:  1.70E+7nMAssay Description:Binding affinity to human MMP3 catalytic domain (81 to 256 residues) expressed in Escherichia coli BL21 (DE3) pLysS by 15N-HSQC-NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50: 0.0380nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.191nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50348668(CHEMBL1801056)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50082556(AG-3340 | 2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benz...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50227724(N-hydroxy-2-methyl-2-{4-[2-methyl-3'-(2-methylamin...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50592894(CHEMBL473539)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50227723(2-{4-[3'-(2-amino-ethoxy)-2-methyl-biphenyl-4-yl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50097273((R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50: 0.5nMAssay Description:Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50097273((R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50: 0.600nMAssay Description:Activity against Matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.650nMAssay Description:Activity against Matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Istituto Di Cristallografia

LigandPNGBDBM50104001(4-(benzylthio)-N-hydroxy-2-(N-isobutyl-4-methoxyph...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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