Compile Data Set for Download or QSAR
Found 648 Enz. Inhib. hit(s) with Target = 'Sucrase-isomaltase, intestinal'
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50147013(CHEMBL3764559)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1[N+]([O-])=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C18H28NO10S.ClH/c20-5-12(22)17(26)18(29-7-10-3-1-2-4-11(10)19(27)28)14(24)9-30-8-13(23)16(25)15(30)6-21;/h1-4,12-18,20-26H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,30?;/m0./s1
Affinity DataKi:  0.0900nMAssay Description:Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50147016(CHEMBL3763300)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1Cl)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C18H28ClO8S.ClH/c19-11-4-2-1-3-10(11)7-27-18(17(26)12(22)5-20)14(24)9-28-8-13(23)16(25)15(28)6-21;/h1-4,12-18,20-26H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,28?;/m0./s1
Affinity DataKi:  0.100nMAssay Description:Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50147107(CHEMBL3763319)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H28F3O8S.ClH/c20-19(21,22)11-4-2-1-3-10(11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/m0./s1
Affinity DataKi:  0.110nMAssay Description:Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291029((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  0.150nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50147158(CHEMBL3764745)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1cccc(c1)C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H28F3O8S.ClH/c20-19(21,22)11-3-1-2-10(4-11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/m0./s1
Affinity DataKi:  0.180nMAssay Description:Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50147159(CHEMBL3764813)
Show SMILES [Cl-].OC[C@H](O)[C@@H](O)[C@@H](OCc1ccc(cc1)C(F)(F)F)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C19H28F3O8S.ClH/c20-19(21,22)11-3-1-10(2-4-11)7-30-18(17(29)12(25)5-23)14(27)9-31-8-13(26)16(28)15(31)6-24;/h1-4,12-18,23-29H,5-9H2;1H/q+1;/p-1/t12-,13+,14+,15+,16-,17+,18-,31?;/m0./s1
Affinity DataKi:  0.400nMAssay Description:Competitive inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291026((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
Affinity DataKi:  3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50327504(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant C-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291031((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  8nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291031((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  8nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291023((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
Affinity DataKi:  10nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291021((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
Affinity DataKi:  16nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291034((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
Affinity DataKi:  16nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291020((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
Affinity DataKi:  17nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291030((2R,3R,4R,5S)-1-[4-(Dimethyl-phenyl-silanyl)-butyl...)
Show SMILES C[Si](C)(CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C18H31NO4Si/c1-24(2,14-8-4-3-5-9-14)11-7-6-10-19-12-16(21)18(23)17(22)15(19)13-20/h3-5,8-9,15-18,20-23H,6-7,10-13H2,1-2H3/t15-,16+,17-,18-/m1/s1
Affinity DataKi:  18nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18353((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
Affinity DataKi:  20nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
Affinity DataKi:  24nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291020((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
Affinity DataKi:  27nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291034((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
Affinity DataKi:  33nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50327504(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant N-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291030((2R,3R,4R,5S)-1-[4-(Dimethyl-phenyl-silanyl)-butyl...)
Show SMILES C[Si](C)(CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C18H31NO4Si/c1-24(2,14-8-4-3-5-9-14)11-7-6-10-19-12-16(21)18(23)17(22)15(19)13-20/h3-5,8-9,15-18,20-23H,6-7,10-13H2,1-2H3/t15-,16+,17-,18-/m1/s1
Affinity DataKi:  39nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291021((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
Affinity DataKi:  40nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291026((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
Affinity DataKi:  50nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50242818(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)
Show SMILES OC1CC(O)C(O)C(O)CS(=O)CC(O)C(O)C(O)C(O)C1
Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2
Affinity DataKi:  52nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291032((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)c1cccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-5-11(7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
Affinity DataKi:  55nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291027((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
Affinity DataKi:  64nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291029((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  100nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50327502((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
Affinity DataKi:  103nMAssay Description:Inhibition of human recombinant C-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291028((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  110nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291031((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  120nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291022((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
Affinity DataKi:  150nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291033((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
Affinity DataKi:  160nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330955((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
Affinity DataKi:  200nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291025((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-4-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h5,7,10-13,15-18H,4,6,8-9H2,1-3H3/b7-5+/t10-,11+,12-,13-/m1/s1
Affinity DataKi:  220nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50327502((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
Affinity DataKi:  302nMAssay Description:Inhibition of human recombinant N-terminal Sucrase-isomaltase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291035((2R,3R,4R,5S)-2-Hydroxymethyl-1-((Z)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C/CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4-/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  350nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291023((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
Affinity DataKi:  390nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50316179((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
Affinity DataKi:  420nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291035((2R,3R,4R,5S)-2-Hydroxymethyl-1-((Z)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C/CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4-/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  640nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291027((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
Affinity DataKi:  830nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330955((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of rat intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291022((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
Affinity DataKi:  3.30E+3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291033((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
Affinity DataKi:  3.50E+3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291024((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
Affinity DataKi:  4.00E+3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50242818(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)
Show SMILES OC1CC(O)C(O)C(O)CS(=O)CC(O)C(O)C(O)C(O)C1
Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of rat intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50316179((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of rat intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50373981(CHEMBL403239)
Show SMILES Nc1c(O)cccc1O
Show InChI InChI=1S/C6H7NO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H,7H2
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of sucrose hydrolyzing activity of rat intestinal alpha glucosidaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291028((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
Affinity DataKi:  7.00E+3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291024((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
Affinity DataKi:  8.50E+3nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal sucraseMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50291032((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)c1cccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-5-11(7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
Affinity DataKi:  1.15E+4nMAssay Description:Tested in vitro for the inhibition constant against rat small intestinal isomaltaseMore data for this Ligand-Target Pair
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