Compile Data Set for Download or QSAR
Report error Found 5274 Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1'
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataKd:  5nMAssay Description:Dissociation constant for TGF-beta receptor type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329814((Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1...)
Affinity DataEC50:  2.18E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329793((Z)-3-((4-(N-(2-(dimethylamino)ethyl)acetamido)phe...)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329794((Z)-3-((4-(N-(2-(dimethylamino)ethyl)acetamido)phe...)
Affinity DataEC50:  102nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329800((Z)-3-((4-(2-(dimethylamino)-N-methylacetamido)phe...)
Affinity DataEC50:  3.38E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329799((Z)-3-((4-((dimethylamino)methyl)phenylamino)(phen...)
Affinity DataEC50:  185nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329797((Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1...)
Affinity DataEC50:  1.37E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329796((Z)-3-((4-(N-(3-(dimethylamino)propyl)acetamido)ph...)
Affinity DataEC50:  411nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329815((Z)-N-ethyl-2-oxo-3-((4-(piperidin-1-ylmethyl)phen...)
Affinity DataEC50:  376nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50279163(CHEMBL496861 | CHEMBL1203981)
Affinity DataEC50:  246nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50279164((3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDI...)
Affinity DataEC50:  105nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329787((Z)-N-(2-hydroxyethyl)-2-oxo-3-(phenyl(4-(piperidi...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329792((Z)-3-((4-(N-(2-(dimethylamino)ethyl)methylsulfona...)
Affinity DataEC50:  209nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329795((Z)-3-((4-(N-(3-(dimethylamino)propyl)acetamido)ph...)
Affinity DataEC50:  1.25E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255231(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255960(4-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)thiazo...)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255228(N-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-flu...)
Affinity DataEC50:  2.81E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255958(6-(4-(5-fluoro-6-methylpyridin-2-yl)-2-(4-(methyls...)
Affinity DataEC50:  4.12E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255908(4-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-flu...)
Affinity DataEC50:  4.63E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255227(N-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(6-met...)
Affinity DataEC50:  5.78E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255231(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  61nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255960(4-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)thiazo...)
Affinity DataEC50:  80nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255228(N-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-flu...)
Affinity DataEC50:  111nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255906(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  148nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255230(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  156nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255227(N-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(6-met...)
Affinity DataEC50:  165nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255179(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  180nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255909(6-(4-(5-fluoro-6-methylpyridin-2-yl)-2-(4-methylpi...)
Affinity DataEC50:  344nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255958(6-(4-(5-fluoro-6-methylpyridin-2-yl)-2-(4-(methyls...)
Affinity DataEC50:  414nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255908(4-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-flu...)
Affinity DataEC50:  513nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255957(1-(4-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-...)
Affinity DataEC50:  1.22E+3nMAssay Description:Inhibition of TGFBR1 transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255909(6-(4-(5-fluoro-6-methylpyridin-2-yl)-2-(4-methylpi...)
Affinity DataEC50:  1.09E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255230(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  1.35E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255957(1-(4-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-...)
Affinity DataEC50:  1.42E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255179(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  1.48E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50255906(N-(4-(5-fluoro-6-methylpyridin-2-yl)-5-(quinoxalin...)
Affinity DataEC50:  1.48E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329784((Z)-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)...)
Affinity DataEC50:  75nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329785((Z)-N-butyl-2-oxo-3-(phenyl(4-(piperidin-1-ylmethy...)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329786((Z)-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)...)
Affinity DataEC50:  696nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50279162((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataEC50:  708nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329790((Z)-N,N-dimethyl-2-oxo-3-(phenyl(4-(piperidin-1-yl...)
Affinity DataEC50:  198nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50110208(SB-431542 | cid_4521392 | 4-(5-(benzo[d][1,3]dioxo...)
Affinity DataEC50:  172nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329791((Z)-3-((4-(N-(2-(dimethylamino)ethyl)methylsulfona...)
Affinity DataEC50:  108nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329798((Z)-N-ethyl-N-methyl-3-((4-(N-methyl-2-(4-methylpi...)
Affinity DataEC50:  833nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329801((Z)-3-((4-(2-(dimethylamino)-N-methylacetamido)phe...)
Affinity DataEC50:  382nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329802((Z)-N-ethyl-3-((4-((ethylamino)methyl)phenylamino)...)
Affinity DataEC50:  160nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329803((Z)-3-((4-(2-(diethylamino)ethylcarbamoyl)phenylam...)
Affinity DataEC50:  505nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329804((Z)-3-((4-(2-(diethylamino)ethylcarbamoyl)phenylam...)
Affinity DataEC50:  542nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50329805((Z)-3-((4-(2-(dimethylamino)ethyl)phenylamino)(phe...)
Affinity DataEC50:  135nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
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